/* Genome overview — mirrors protein-detail / binder-detail design language. */

.genome-page {
    font-family: "Source Sans 3", "Segoe UI", sans-serif;
    color: var(--tp-ink);
    margin: 0;
    display: grid;
    gap: var(--tp-space-4);
    --genome-accent: var(--tp-color-brand-800);
    --genome-accent-ink: var(--tp-color-brand-900);
    --genome-accent-soft: var(--tp-color-brand-100);
    --genome-accent-border: var(--tp-color-brand-300);
}

.genome-page h1,
.genome-page h2,
.genome-page h3 {
    font-family: "Space Grotesk", "Segoe UI", sans-serif;
    font-weight: 600;
    letter-spacing: 0.2px;
}
.genome-page h1 { font-weight: 700; }

/* ── Hero ─────────────────────────────────────────────────────────── */

/* Base styles from .tp-page-hero in ui-system.css */

.genome-hero-top {
    display: flex;
    justify-content: space-between;
    gap: 18px;
    align-items: flex-start;
    margin-top: 8px;
}

.genome-hero-content {
    max-width: none;
    width: 100%;
    min-width: 0;
}

.genome-hero-eyebrow {
    margin: 6px 0 10px;
    color: var(--tp-color-text-muted);
    font-size: var(--tp-font-label);
    font-weight: 500;
    letter-spacing: 0.08em;
    text-transform: uppercase;
}

.genome-hero h1 {
    margin: 0;
    font-size: var(--tp-heading-lg);
    line-height: 1.1;
    color: var(--genome-accent-ink);
    word-break: break-all;
}

.genome-curated-callout {
    display: flex;
    align-items: center;
    gap: 10px;
    margin-top: 8px;
}

.genome-curated-callout-note {
    color: var(--tp-color-text-muted);
    font-size: 0.88rem;
    line-height: 1.35;
}

.genome-description {
    margin: 10px 0 0;
    color: var(--tp-color-text-secondary);
    font-size: 1rem;
    line-height: 1.42;
    max-width: 920px;
}


.genome-hero .hero-chip-list {
    margin-top: 12px;
}

.genome-hero .hero-chip {
    display: inline-flex;
    align-items: baseline;
    gap: 6px;
}

.genome-pipeline-group {
    margin-top: 12px;
    display: flex;
    flex-direction: column;
    gap: 6px;
    align-items: flex-start;
    max-width: min(100%, 720px);
}

.hero-pipeline-note {
    margin: 0;
    color: var(--tp-color-text-muted);
    font-size: 0.84rem;
    font-weight: 500;
    line-height: 1.35;
}

.genome-hero-actions {
    display: flex;
    flex-wrap: wrap;
    gap: 10px;
    margin-top: 18px;
}

.genome-hero-actions .tp-btn--primary {
    min-width: 196px;
    justify-content: center;
}

/* ── Metric pills ─────────────────────────────────────────────────── */

.genome-metrics {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(180px, 1fr));
    gap: 10px;
    margin-top: 14px;
}

.genome-page .metric-pill {
    border: 1px solid var(--tp-color-border-soft);
    border-radius: 10px;
    background: var(--tp-color-surface-soft);
    padding: 10px 12px;
    min-height: 68px;
    display: grid;
    align-content: center;
    gap: 2px;
}

.genome-page .metric-label {
    font-size: var(--tp-font-label);
    font-weight: 500;
    text-transform: uppercase;
    letter-spacing: 0.05em;
    color: var(--tp-color-text-muted);
}

.genome-page .metric-value {
    color: var(--genome-accent-ink);
    font-size: 1.4rem;
    line-height: 1.1;
    font-weight: 600;
    display: flex;
    align-items: baseline;
    gap: 8px;
}

.metric-value-pct {
    font-size: 0.85rem;
    font-weight: 600;
    color: var(--tp-color-text-muted);
}

/* ── Quick-nav ────────────────────────────────────────────────────── */

.genome-page .quick-nav {
    position: sticky;
    top: -2px;
    z-index: 25;
    display: flex;
    flex-wrap: nowrap;
    gap: 8px;
    overflow-x: auto;
    padding: 8px 10px;
    border: 1px solid var(--tp-color-border-soft);
    border-radius: 10px;
    background: var(--tp-color-surface-soft);
}

.genome-page .quick-nav::-webkit-scrollbar {
    height: 6px;
}

.genome-page .quick-nav::-webkit-scrollbar-thumb {
    background: var(--tp-color-border-strong);
    border-radius: 999px;
}

.genome-page .quick-nav .quick-nav-link {
    flex: 0 0 auto;
    display: inline-flex;
    align-items: center;
    justify-content: center;
    text-align: center;
    min-height: 34px;
    padding: 0.28rem 0.9rem;
    line-height: 1.1;
    font-weight: 500;
    border-radius: 999px;
    border: 1px solid var(--tp-color-border) !important;
    background: transparent !important;
    color: var(--tp-color-text-secondary) !important;
    white-space: nowrap;
    text-decoration: none !important;
    transition: border-color 120ms ease, color 120ms ease, background 120ms ease;
}

.genome-page .quick-nav .quick-nav-link:hover,
.genome-page .quick-nav .quick-nav-link:focus-visible {
    color: var(--tp-color-text-primary) !important;
    border-color: var(--tp-color-border-strong) !important;
    background: var(--tp-color-surface) !important;
}

.genome-page .quick-nav .quick-nav-link.is-active,
.genome-page .quick-nav .quick-nav-link[aria-current="true"] {
    color: var(--tp-color-link-hover) !important;
    border-color: var(--genome-accent-border) !important;
    background: var(--tp-color-brand-100) !important;
    text-decoration: none !important;
}

.tp-dark .genome-page .quick-nav .quick-nav-link.is-active,
.tp-dark .genome-page .quick-nav .quick-nav-link[aria-current="true"] {
    background: var(--tp-color-brand-200) !important;
    border-color: var(--tp-color-brand-300) !important;
    color: var(--tp-color-brand-900) !important;
}

/* ── Grid + panels ────────────────────────────────────────────────── */

.genome-grid {
    display: grid;
    grid-template-columns: repeat(2, minmax(0, 1fr));
    gap: 14px;
}

.genome-card {
    border: 1px solid var(--tp-color-border);
    border-radius: var(--tp-ui-radius-panel);
    background: var(--tp-color-surface);
    padding: 16px;
    overflow: hidden;
    scroll-margin-top: 128px;
}

.genome-card h2 {
    margin: 0;
    font-size: var(--tp-heading-sm);
    font-weight: 600;
    color: var(--genome-accent-ink);
}

.genome-page .section-head {
    display: flex;
    justify-content: space-between;
    align-items: flex-start;
    gap: 10px;
    margin-bottom: 12px;
}

.genome-page .section-subtitle {
    margin: 4px 0 0;
    color: var(--tp-color-text-muted);
    font-size: 0.86rem;
    line-height: 1.45;
}

.genome-targets-wrap,
.genome-card--evidence,
.genome-card--browse,
.genome-card--downloads,
.genome-card--details,
.genome-card--danger {
    grid-column: 1 / -1;
}

.genome-card--downloads {
    overflow: visible;
}

.genome-card--downloads .tp-ui-toolbar-form {
    max-width: 640px;
    display: grid;
    grid-template-columns: 1fr auto;
    gap: 14px;
    align-items: end;
    overflow: visible;
}

.genome-card--downloads .tp-ui-field {
    min-width: 0;
    overflow: visible;
}

/* ── Top targets (two rankings side-by-side) ─────────────────────── */

.genome-targets-wrap {
    display: grid;
    grid-template-columns: repeat(2, minmax(0, 1fr));
    gap: 14px;
    scroll-margin-top: 128px;
}

@media (max-width: 991px) {
    .genome-page .quick-nav {
        top: 64px;
    }
}

@media (max-width: 980px) {
    .genome-targets-wrap {
        grid-template-columns: minmax(0, 1fr);
    }
}

.genome-card--ranking {
    display: flex;
    flex-direction: column;
    align-self: stretch;
}

/* Clamp descriptions to 1 line for uniform item height */
.genome-card--ranking .targets-description {
    -webkit-line-clamp: 1;
}

/* Breakdown chips inside targets-main (right card) align left like factor chips */
.genome-card--ranking .targets-breakdown {
    justify-content: flex-start;
    padding-left: 38px;
    flex-wrap: nowrap;
    overflow-x: clip;
}

.targets-list {
    list-style: none;
    margin: 0;
    padding: 0;
    counter-reset: targets-counter;
    display: flex;
    flex-direction: column;
    gap: 10px;
}

.targets-item {
    border: 1px solid var(--tp-color-border-soft);
    border-radius: 10px;
    background: var(--tp-color-surface);
    transition: border-color 140ms ease;
}

.targets-item:hover {
    border-color: var(--tp-color-border-strong);
}

.targets-link {
    display: grid;
    grid-template-columns: 1fr auto;
    gap: 16px;
    align-items: center;
    padding: 14px 16px;
    color: inherit;
    text-decoration: none;
}

.targets-link--score {
    grid-template-columns: 1fr;
    align-items: stretch;
}

.targets-score {
    margin-left: auto;
    font-weight: var(--tp-font-weight-semibold);
    color: var(--genome-accent-ink);
    line-height: 1;
    padding: 5px 10px;
    background: var(--genome-accent-soft);
    border: 1px solid var(--genome-accent-border);
    border-radius: 8px;
    display: inline-flex;
    align-items: baseline;
    gap: 6px;
}

.targets-score-label {
    color: var(--tp-color-text-muted);
    font-size: 0.68rem;
    font-weight: 500;
    letter-spacing: 0.04em;
    text-transform: uppercase;
}

.targets-score-value {
    font-size: 0.9rem;
    font-variant-numeric: tabular-nums;
}

.targets-direct-count {
    margin-left: auto;
    font-size: 0.84rem;
    font-weight: var(--tp-font-weight-semibold);
    color: var(--tp-color-sage-900, var(--tp-color-text-primary));
    line-height: 1;
    padding: 4px 10px;
    background: var(--tp-color-sage-050);
    border: 1px solid var(--tp-color-sage-200);
    border-radius: 8px;
    white-space: nowrap;
}

.targets-evidence {
    font-family: "JetBrains Mono", "SFMono-Regular", Menlo, Consolas, monospace;
    font-size: 0.78rem;
    font-weight: 600;
    line-height: 1;
    color: var(--tp-color-text-muted);
    padding: 4px 10px;
    background: var(--tp-color-surface-soft);
    border: 1px solid var(--tp-color-border-soft);
    border-radius: 999px;
    position: relative;
    cursor: help;
}

/* Chips that contain a .targets-tooltip get the (i) hint + relative anchor. */
.targets-bd:has(> .targets-tooltip),
.targets-evidence:has(> .targets-tooltip) {
    position: relative;
    cursor: help;
}

.targets-bd:has(> .targets-tooltip) strong::after {
    content: "i";
    display: inline-flex;
    align-items: center;
    justify-content: center;
    width: 13px;
    height: 13px;
    margin-left: 4px;
    border-radius: 50%;
    border: 1px solid currentColor;
    font-size: 9px;
    font-style: italic;
    font-weight: 500;
    vertical-align: middle;
    opacity: 0.5;
    line-height: 1;
}

/* Custom tooltip — same look as .cell-tooltip used across the app. */
.targets-tooltip {
    position: absolute;
    bottom: calc(100% + 8px);
    left: 50%;
    transform: translateX(-50%);
    padding: 8px 12px;
    border-radius: 8px;
    background: var(--tp-tooltip-bg);
    color: var(--tp-tooltip-color);
    font-size: 0.78rem;
    font-weight: 500;
    line-height: 1.45;
    white-space: normal;
    width: max-content;
    max-width: 280px;
    text-align: center;
    pointer-events: none;
    opacity: 0;
    transition: opacity 140ms ease;
    z-index: 50;
    box-shadow: var(--tp-shadow-lg);
}

.targets-tooltip::after {
    content: "";
    position: absolute;
    top: 100%;
    left: 50%;
    transform: translateX(-50%);
    border: 5px solid transparent;
    border-top-color: var(--tp-tooltip-bg);
}

.targets-bd:hover .targets-tooltip,
.targets-bd:focus-visible .targets-tooltip,
.targets-evidence:hover .targets-tooltip,
.targets-evidence:focus-visible .targets-tooltip {
    opacity: 1;
}

/* Anchor leftmost / rightmost chips so their tooltips don't overflow horizontally.
   PDB is the leftmost chip in the breakdown row → tooltip extends to the right.
   ZINC is the rightmost → tooltip extends to the left.
   .targets-evidence sits on the right edge of the score ranking → same as ZINC.
   ChEMBL stays centered (default). */
.targets-bd--pdb .targets-tooltip {
    left: 0;
    transform: none;
}

.targets-bd--pdb .targets-tooltip::after {
    left: 20px;
    transform: none;
}

.targets-bd--zinc .targets-tooltip,
.targets-evidence .targets-tooltip {
    left: auto;
    right: 0;
    transform: none;
}

.targets-bd--zinc .targets-tooltip::after,
.targets-evidence .targets-tooltip::after {
    left: auto;
    right: 20px;
    transform: none;
}

.targets-factors {
    display: flex;
    flex-wrap: wrap;
    gap: 6px;
    padding-left: 38px;
}

.targets-factor {
    font-size: var(--tp-font-label);
    font-weight: 600;
    padding: 3px 9px;
    border-radius: 999px;
    border: 1px solid transparent;
    white-space: nowrap;
}

.targets-factor--good {
    background: var(--tp-color-success-bg);
    color: var(--tp-color-success-ink);
    border-color: var(--tp-color-success-border);
}

.targets-factor--bad {
    background: var(--tp-color-danger-bg);
    color: var(--tp-color-danger-ink);
    border-color: var(--tp-color-danger-border);
}

.targets-factor--neutral {
    background: var(--tp-color-surface-soft);
    color: var(--tp-color-text-secondary);
    border-color: var(--tp-color-border-soft);
}

@media (max-width: 720px) {
    .targets-factors {
        padding-left: 0;
    }
}

.targets-footnote {
    margin: 18px 0 0;
    padding-top: 12px;
    border-top: 1px dashed var(--tp-color-border-soft);
    font-size: 0.86rem;
    color: var(--tp-color-text-muted);
}

.targets-footnote a {
    color: var(--tp-color-link);
    font-weight: 600;
    text-decoration: none;
}

.targets-footnote a:hover,
.targets-footnote a:focus-visible {
    text-decoration: underline;
}

.targets-link:hover,
.targets-link:focus-visible {
    text-decoration: none;
    color: inherit;
    outline: none;
}

.targets-main {
    min-width: 0;
    display: grid;
    gap: 6px;
}

.targets-title {
    display: flex;
    align-items: baseline;
    gap: 10px;
}

.targets-rank {
    font-family: "JetBrains Mono", "SFMono-Regular", Menlo, Consolas, monospace;
    font-size: 0.95rem;
    font-weight: 600;
    color: var(--tp-color-text-muted);
    min-width: 28px;
}

.targets-accession {
    font-family: "JetBrains Mono", "SFMono-Regular", Menlo, Consolas, monospace;
    font-size: 1.1rem;
    font-weight: 600;
    color: var(--genome-accent-ink);
}

.targets-description {
    margin: 0;
    color: var(--tp-color-text-secondary);
    font-size: 0.95rem;
    line-height: 1.4;
    padding-left: 38px;
    overflow: hidden;
    display: -webkit-box;
    -webkit-line-clamp: 2;
    -webkit-box-orient: vertical;
}

.targets-stats {
    display: flex;
    flex-direction: column;
    align-items: flex-end;
    gap: 8px;
    flex: 0 0 auto;
}

.targets-stat--total {
    display: flex;
    align-items: baseline;
    gap: 6px;
    color: var(--genome-accent-ink);
}

.targets-stat-value {
    font-size: 1.6rem;
    font-weight: 600;
    line-height: 1;
    font-family: "Space Grotesk", "Segoe UI", sans-serif;
}

.targets-stat-label {
    font-size: 0.78rem;
    font-weight: 500;
    text-transform: uppercase;
    letter-spacing: 0.06em;
    color: var(--tp-color-text-muted);
}

.targets-breakdown {
    display: flex;
    flex-wrap: wrap;
    gap: 6px;
    padding-left: 38px;
}

.targets-bd {
    font-size: var(--tp-font-label);
    font-weight: 600;
    padding: 3px 8px;
    border-radius: 999px;
    border: 1px solid transparent;
    white-space: nowrap;
}

.targets-bd strong {
    font-weight: 600;
}

.targets-bd--pdb,
.targets-bd--pdb-direct {
    background: var(--tp-color-brand-100);
    color: var(--tp-color-brand-900);
    border-color: var(--tp-color-brand-300);
}

.targets-bd--chembl,
.targets-bd--chembl-direct {
    background: color-mix(in srgb, var(--tp-color-sage-700) 12%, var(--tp-color-surface));
    color: var(--tp-color-sage-900, var(--tp-color-text-primary));
    border-color: color-mix(in srgb, var(--tp-color-sage-700) 28%, var(--tp-color-border-soft));
}

.targets-bd--homolog {
    background: var(--tp-color-surface-muted);
    color: var(--tp-color-text-secondary);
    border-color: var(--tp-color-border-soft);
}

.targets-bd--zinc {
    background: var(--tp-color-info-bg);
    color: var(--tp-color-text-primary);
    border-color: var(--tp-color-border-soft);
}

@media (max-width: 720px) {
    .targets-link {
        grid-template-columns: 1fr;
    }
    .targets-stats {
        align-items: flex-start;
    }
    .targets-breakdown {
        justify-content: flex-start;
    }
    .targets-description {
        padding-left: 0;
    }
}

@media (max-width: 880px) {
    .genome-grid {
        grid-template-columns: minmax(0, 1fr);
    }
}

/* ── Evidence available ──────────────────────────────────────────── */

.evidence-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(260px, 1fr));
    gap: 14px;
}

.evidence-card {
    border: 1px solid var(--tp-color-border-soft);
    border-radius: 10px;
    background: var(--tp-color-surface);
    padding: 16px 18px;
    display: flex;
    flex-direction: column;
    gap: 10px;
    position: relative;
    overflow: hidden;
}

.evidence-card::before {
    content: "";
    position: absolute;
    top: 0;
    left: 0;
    right: 0;
    height: 3px;
    background: var(--evidence-accent, var(--tp-color-brand-700));
}

.evidence-card--structure {
    --evidence-accent: var(--tp-color-brand-700);
}

.evidence-card--annotation {
    --evidence-accent: var(--tp-color-sage-700);
}

.evidence-card--binders {
    --evidence-accent: var(--tp-color-brand-600);
}

.evidence-label {
    font-size: var(--tp-font-label);
    font-weight: 500;
    text-transform: uppercase;
    letter-spacing: 0.06em;
    color: var(--tp-color-text-muted);
}

.evidence-headline {
    font-size: 1.45rem;
    font-weight: 600;
    color: var(--genome-accent-ink);
    line-height: 1.1;
    display: flex;
    flex-direction: column;
    gap: 4px;
}

.evidence-headline-sub {
    font-size: 0.88rem;
    font-weight: 500;
    color: var(--tp-color-text-muted);
}

.evidence-breakdown {
    list-style: none;
    margin: 0;
    padding: 0;
    display: flex;
    flex-direction: column;
    gap: 6px;
    border-top: 1px dashed var(--tp-color-border-soft);
    padding-top: 10px;
}

.evidence-breakdown li {
    display: flex;
    justify-content: space-between;
    align-items: baseline;
    gap: 8px;
    font-size: 0.92rem;
}

.evidence-breakdown-priority {
    padding: 5px 8px;
    margin-inline: -8px;
    border-radius: 8px;
    background: var(--tp-color-sage-050);
}

.evidence-breakdown-priority .evidence-bd-label {
    color: var(--tp-color-sage-900);
}

.evidence-bd-label {
    color: var(--tp-color-text-secondary);
    font-weight: 600;
}

.evidence-bd-value {
    font-family: "JetBrains Mono", "SFMono-Regular", Menlo, Consolas, monospace;
    color: var(--genome-accent-ink);
    font-weight: 600;
}

/* ── Composition inline (within Evidence section) ────────────────── */

.evidence-composition {
    display: flex;
    flex-wrap: wrap;
    gap: 12px 24px;
    padding-top: 14px;
    margin-top: 14px;
    border-top: 1px dashed var(--tp-color-border-soft);
}

.evidence-composition-item {
    display: flex;
    align-items: baseline;
    gap: 6px;
}

.evidence-composition-label {
    font-size: var(--tp-font-label);
    font-weight: 500;
    text-transform: uppercase;
    letter-spacing: 0.05em;
    color: var(--tp-color-text-muted);
}

.evidence-composition-value {
    font-family: "JetBrains Mono", "SFMono-Regular", Menlo, Consolas, monospace;
    font-size: 0.88rem;
    font-weight: 600;
    color: var(--genome-accent-ink);
}

/* ── JBrowse iframe ──────────────────────────────────────────────── */

.jbrowse-frame {
    width: 100%;
    height: 540px;
    border: 1px solid var(--tp-color-border-soft);
    border-radius: 10px;
    overflow: hidden;
    background: var(--tp-color-surface-soft);
}

.jbrowse-frame iframe {
    width: 100%;
    height: 100%;
    border: 0;
}

/* ── Evidence footnote ───────────────────────────────────────────── */

.evidence-footnote {
    margin: 14px 0 0;
    padding-top: 12px;
    border-top: 1px dashed var(--tp-color-border-soft);
    font-size: 0.82rem;
    color: var(--tp-color-text-muted);
    line-height: 1.45;
    font-style: italic;
}

/* ── Imported details ────────────────────────────────────────────── */

.genome-raw-details summary {
    cursor: pointer;
    color: var(--genome-accent-ink);
    font-weight: 500;
    list-style: none;
    display: inline-flex;
    align-items: center;
    gap: 8px;
    min-height: 34px;
    padding: 0 14px;
    border: 1px solid var(--tp-color-border-strong);
    border-radius: 999px;
    background: var(--tp-color-surface);
    transition: border-color 140ms ease, background 140ms ease;
}

.genome-raw-details summary::-webkit-details-marker {
    display: none;
}

.genome-raw-details summary:hover,
.genome-raw-details summary:focus-visible {
    outline: none;
    border-color: var(--genome-accent-border);
    background: var(--tp-color-surface-soft);
}

.genome-raw-details[open] summary {
    margin-bottom: 12px;
    border-color: var(--genome-accent-border);
    background: var(--tp-color-brand-050);
}

.genome-raw-table {
    margin-top: 10px;
}

/* ── Dataset deletion danger card ────────────────────────────────── */

.genome-card--danger {
    border-color: var(--tp-color-danger-border);
    background: var(--tp-color-danger-bg);
}

.genome-card--danger h2 {
    color: var(--tp-color-danger-ink);
}

.genome-delete-summary summary {
    cursor: pointer;
    list-style: none;
    display: inline-flex;
    align-items: center;
    gap: 8px;
    min-height: 34px;
    padding: 0 14px;
    border: 1px solid var(--tp-color-danger-border);
    border-radius: 999px;
    background: var(--tp-color-danger-bg);
    color: var(--tp-color-danger-ink);
    font-size: 0.9rem;
    font-weight: 500;
    transition: border-color 140ms ease, background 140ms ease;
}

.genome-delete-summary summary::-webkit-details-marker {
    display: none;
}

.genome-delete-summary[open] summary {
    margin-bottom: 12px;
}

.genome-delete-form {
    display: grid;
    gap: 10px;
}

.genome-delete-copy {
    margin: 0;
    color: var(--tp-color-text-secondary);
    font-size: 0.92rem;
    line-height: 1.45;
}

.genome-delete-actions {
    display: flex;
    justify-content: flex-end;
    gap: 10px;
    flex-wrap: wrap;
}

@media (max-width: 640px) {
    .genome-hero {
        padding: 18px 16px 16px;
    }

    .genome-hero-actions .btn,
    .genome-delete-actions .btn {
        width: 100%;
    }
}