/*
 * Human Targets — protein detail page.
 *
 * Deliberately narrow: the hero/card/quick-nav/metric-pill/binders-table/
 * binder-intel/binder-mol-modal styling is reused verbatim from
 * protein-detail.css (same markup, same tokens, loaded alongside this file
 * -- see human_protein.html's {% block head %}), so this file only adds the
 * genuinely new human-specific classes (Overview/Function/Sequence/
 * Structure/Cross-refs) plus the custom properties the reused classes
 * expect from their normal `.protein-page` ancestor, aliased here onto
 * `.human-protein-page` instead.
 */

/* Base font/color/spacing and the --protein-accent* custom properties
   (light + dark-mode-corrected values) all come from the real `.protein-page`
   class, added alongside this one in human_protein.html -- this page reuses
   protein-detail.css's hero/card/binders styling verbatim and must pick up
   its `.tp-dark .protein-page` dark-mode accent overrides too, not just its
   light-mode values. Only the genuinely new `--human-accent` lives here. */
.human-protein-page {
    --human-accent: var(--tp-color-brand-800);
}

.hero-chip-reviewed {
    background: var(--tp-color-success-bg);
    color: var(--tp-color-success-ink);
    border-color: var(--tp-color-success-border);
}

/* Overview */

.human-overview-grid {
    display: grid;
    grid-template-columns: minmax(0, 2fr) minmax(240px, 1fr);
    gap: var(--tp-space-6);
    align-items: start;
}

@media (max-width: 900px) {
    .human-overview-grid {
        grid-template-columns: 1fr;
    }
}

.human-overview-block {
    margin-top: var(--tp-space-4);
}

.human-overview-block h3 {
    font-size: var(--tp-font-size-md);
    margin-bottom: var(--tp-space-2);
}

.human-caution {
    margin-top: var(--tp-space-3);
}

.human-publication-list {
    margin: 0;
    padding-left: var(--tp-space-4);
    font-size: var(--tp-font-size-sm);
}

.human-publication-list li {
    margin-bottom: var(--tp-space-1);
}

.human-identifiers-card,
.human-pill-block {
    background: var(--tp-color-surface-soft);
    border: 1px solid var(--tp-color-border-soft);
    border-radius: 12px;
    padding: var(--tp-space-4);
    margin-bottom: var(--tp-space-4);
}

.human-identifiers-card h3,
.human-pill-block h3 {
    font-size: var(--tp-font-label);
    text-transform: uppercase;
    letter-spacing: 0.06em;
    color: var(--tp-color-text-muted);
    margin-bottom: var(--tp-space-3);
}

.human-kv-list {
    display: grid;
    grid-template-columns: auto 1fr;
    gap: var(--tp-space-1) var(--tp-space-3);
    margin: 0;
}

.human-kv-list dt {
    color: var(--tp-color-text-muted);
    font-size: var(--tp-font-size-sm);
}

.human-kv-list dd {
    margin: 0;
    font-size: var(--tp-font-size-sm);
}

.human-lineage {
    margin: var(--tp-space-3) 0 0;
    font-size: var(--tp-font-size-xs);
    color: var(--tp-color-text-muted);
}

/* Function */

.human-function-text {
    white-space: pre-line;
    line-height: 1.6;
}

.human-catalytic-list {
    display: grid;
    gap: var(--tp-space-2);
    margin-top: var(--tp-space-4);
}

.human-catalytic-card {
    border: 1px solid var(--tp-color-border-soft);
    border-radius: 12px;
    padding: var(--tp-space-3);
    display: flex;
    flex-wrap: wrap;
    align-items: center;
    gap: var(--tp-space-2);
}

.human-reaction-eq {
    margin: 0;
    font-family: "Space Grotesk", "Segoe UI", sans-serif;
    flex-basis: 100%;
}

.human-go-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(220px, 1fr));
    gap: var(--tp-space-3);
    margin-top: var(--tp-space-4);
}

.human-go-card {
    background: var(--tp-color-surface-soft);
    border: 1px solid var(--tp-color-border-soft);
    border-radius: 12px;
    padding: var(--tp-space-3);
}

.human-go-card h3 {
    font-size: var(--tp-font-size-sm);
    color: var(--tp-color-text-muted);
    margin-bottom: var(--tp-space-2);
}

/* Sequence */

.human-sequence-block {
    font-family: "SFMono-Regular", Consolas, monospace;
    font-size: var(--tp-font-size-sm);
    line-height: 1.6;
    background: var(--tp-color-surface-soft);
    border: 1px solid var(--tp-color-border-soft);
    border-radius: 12px;
    padding: var(--tp-space-4);
    overflow-x: auto;
    white-space: pre-wrap;
    word-break: break-all;
}

/* Seamless mosaic: 1px gaps read as hairline dividers between lanes, no
   per-lane border/shadow/export-toolbar (these are lookup lists of a
   handful of rows each, not sortable/exportable data grids). */
.human-feature-lanes {
    display: grid;
    gap: 1px;
    background: var(--tp-color-border-soft);
    border: 1px solid var(--tp-color-border-soft);
    border-radius: 12px;
    overflow: hidden;
    margin-top: var(--tp-space-4);
}

.human-feature-lane {
    display: grid;
    grid-template-columns: minmax(140px, 180px) 1fr;
    gap: var(--tp-space-3);
    padding: var(--tp-space-3) var(--tp-space-4);
    background: var(--tp-color-surface);
}

@media (max-width: 700px) {
    .human-feature-lane {
        grid-template-columns: 1fr;
    }
}

.human-feature-lane__label {
    font-size: var(--tp-font-label);
    text-transform: uppercase;
    letter-spacing: 0.06em;
    color: var(--tp-color-text-muted);
    padding-top: 2px;
}

.human-feature-lane__items {
    display: grid;
    gap: var(--tp-space-1);
}

.human-feature-item {
    display: grid;
    grid-template-columns: 90px 1fr;
    gap: var(--tp-space-2);
    font-size: var(--tp-font-size-sm);
}

.human-feature-item__pos {
    font-family: "SFMono-Regular", Consolas, monospace;
    color: var(--tp-color-text-muted);
}

/* Structure */

.human-structure-tabs {
    display: flex;
    flex-wrap: wrap;
    gap: var(--tp-space-2);
    margin-bottom: var(--tp-space-4);
}

.human-structure-tab {
    display: inline-flex;
    align-items: center;
    gap: var(--tp-space-1);
    border: 1px solid var(--tp-color-border-soft);
    background: var(--tp-color-surface);
    border-radius: 999px;
    padding: var(--tp-space-1) var(--tp-space-3);
    font-size: var(--tp-font-size-sm);
    cursor: pointer;
}

.human-structure-tab.is-active {
    background: var(--human-accent);
    color: var(--tp-color-on-accent);
    border-color: var(--human-accent);
}

.human-structure-tab__count {
    font-size: var(--tp-font-size-xs);
    opacity: 0.8;
}

.human-structure-body {
    display: grid;
    grid-template-columns: minmax(200px, 260px) 1fr;
    gap: var(--tp-space-4);
}

@media (max-width: 900px) {
    .human-structure-body {
        grid-template-columns: 1fr;
    }
}

.human-structure-panel.is-hidden {
    display: none;
}

.human-structure-entry {
    display: flex;
    flex-direction: column;
    align-items: flex-start;
    gap: 2px;
    width: 100%;
    text-align: left;
    border: 1px solid var(--tp-color-border-soft);
    border-radius: 12px;
    padding: var(--tp-space-2) var(--tp-space-3);
    margin-bottom: var(--tp-space-2);
    background: var(--tp-color-surface);
    cursor: pointer;
    font-size: var(--tp-font-size-sm);
}

.human-structure-entry.is-active {
    border-color: var(--human-accent);
    background: var(--tp-color-surface-soft);
}

.human-structure-viewer {
    position: relative;
    min-height: 420px;
    border: 1px solid var(--tp-color-border-soft);
    border-radius: 12px;
    background: var(--tp-color-structure-bg, var(--tp-color-surface-panel));
    overflow: hidden;
}

#human-structure-viewport {
    position: absolute;
    inset: 0;
}

#human-structure-loading {
    position: absolute;
    inset: 0;
    display: flex;
    align-items: center;
    justify-content: center;
    margin: 0;
    pointer-events: none;
}

/* Cross-references */

.human-xref-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(220px, 1fr));
    gap: var(--tp-space-3);
}

.human-xref-card {
    border: 1px solid var(--tp-color-border-soft);
    border-radius: 12px;
    padding: var(--tp-space-3);
    background: var(--tp-color-surface-soft);
}

.human-xref-card h3 {
    font-size: var(--tp-font-label);
    text-transform: uppercase;
    letter-spacing: 0.06em;
    color: var(--tp-color-text-muted);
    margin-bottom: var(--tp-space-2);
}

.human-xref-list {
    list-style: none;
    margin: 0;
    padding: 0;
    display: grid;
    gap: var(--tp-space-1);
}

.human-xref-list li {
    display: flex;
    justify-content: space-between;
    gap: var(--tp-space-2);
    font-size: var(--tp-font-size-sm);
}

.human-xref-db {
    color: var(--tp-color-text-muted);
}

.human-xref-id {
    font-family: "SFMono-Regular", Consolas, monospace;
}

@media (prefers-reduced-motion: reduce) {
    .human-structure-tab,
    .human-structure-entry {
        transition: none;
    }
}