/* Genome-wide unified metabolic network graph -- distinct from both the ranking-card
 * styles in metabolism-overview.css and the ego-network-only rules scoped to
 * protein-detail.css (that page never loads here, so every class this page's markup/JS
 * relies on is defined fresh below, even where the name matches the ego-network's). */

.metabolic-network-genome-caption {
    margin: 8px 0 14px;
    color: var(--tp-color-text-muted);
    font-size: 0.8rem;
    line-height: 1.5;
}

.metabolic-network-genome-shell {
    display: flex;
    flex-direction: column;
    position: relative;
    min-width: 0;
    overflow: hidden;
    border: 1px solid var(--tp-color-border-soft);
    border-radius: var(--tp-ui-radius-panel);
    background: var(--tp-color-surface-soft);
}

.metabolic-network-genome-toolbar {
    display: flex;
    align-items: center;
    justify-content: space-between;
    gap: 12px;
    min-height: 44px;
    padding: 9px 14px;
    border-bottom: 1px solid var(--tp-color-border-soft);
    background: var(--tp-color-surface);
}

.metabolic-network-genome-legend {
    display: flex;
    flex-wrap: wrap;
    align-items: center;
    gap: 8px 14px;
    color: var(--tp-color-text-secondary);
    font-size: 0.74rem;
    font-weight: 600;
}

.metabolic-network-genome-legend span {
    display: inline-flex;
    align-items: center;
    gap: 6px;
    white-space: nowrap;
}

.metabolic-network-genome-dot {
    display: inline-block;
    width: 10px;
    height: 10px;
    border-radius: 999px;
    background: var(--tp-color-surface-soft);
    border: 1.5px solid var(--tp-color-text-soft);
}

.metabolic-network-genome-dot--density-1 {
    background: color-mix(in srgb, var(--tp-color-amber-500) 10%, var(--tp-color-surface-soft));
    border-color: var(--tp-color-text-soft);
}

.metabolic-network-genome-dot--density-2 {
    background: color-mix(in srgb, var(--tp-color-amber-500) 28%, var(--tp-color-surface-soft));
    border-color: var(--tp-color-text-soft);
}

.metabolic-network-genome-dot--density-3 {
    background: color-mix(in srgb, var(--tp-color-amber-500) 52%, var(--tp-color-surface-soft));
    border-color: var(--tp-color-amber-500);
}

.metabolic-network-genome-dot--density-4 {
    background: color-mix(in srgb, var(--tp-color-amber-500) 82%, var(--tp-color-surface-soft));
    border-color: var(--tp-color-amber-500);
}

.metabolic-network-genome-line {
    display: inline-block;
    width: 16px;
    height: 0;
    border-top: 1.5px dashed var(--tp-color-border-strong);
}

.metabolic-network-genome-actions {
    display: inline-flex;
    align-items: center;
    gap: 6px;
    flex: 0 0 auto;
}

.metabolic-network-genome-breadcrumb {
    display: flex;
    align-items: center;
    gap: 8px;
    padding: 8px 14px;
    border-bottom: 1px solid var(--tp-color-border-soft);
    background: color-mix(in srgb, var(--tp-color-brand-500) 5%, var(--tp-color-surface));
    font-size: 0.78rem;
}

.metabolic-network-genome-back-btn {
    display: inline-flex;
    align-items: center;
    gap: 5px;
    padding: 4px 10px 4px 6px;
    border: 1px solid var(--tp-color-border-strong);
    border-radius: 999px;
    background: var(--tp-color-surface);
    color: var(--tp-color-text-secondary);
    font-size: 0.74rem;
    font-weight: 700;
    transition: border-color 140ms ease, background 140ms ease, color 140ms ease, transform 140ms ease;
}

.metabolic-network-genome-back-btn:hover {
    border-color: var(--tp-color-brand-300);
    color: var(--tp-color-text-primary);
    background: var(--tp-color-surface-soft);
    transform: translateX(-1px);
}

.metabolic-network-genome-breadcrumb-sep {
    color: var(--tp-color-text-soft);
}

.metabolic-network-genome-breadcrumb-current {
    color: var(--tp-color-text-primary);
    font-weight: 700;
}

.metabolic-network-genome-body {
    display: grid;
    grid-template-columns: minmax(0, 1fr) minmax(220px, 280px);
    gap: 0;
    min-height: 0;
}

.metabolic-network-genome-canvas-wrap {
    position: relative;
    min-width: 0;
    border-right: 1px solid var(--tp-color-border-soft);
}

.metabolic-network-genome-glow {
    position: absolute;
    inset: 0;
    z-index: 0;
    pointer-events: none;
    background: radial-gradient(
        ellipse at 50% 35%,
        color-mix(in srgb, var(--tp-color-brand-500) 6%, transparent),
        transparent 65%
    );
}

#metabolic-network-genome-cy {
    position: relative;
    z-index: 1;
    width: 100%;
    min-height: clamp(460px, 58vh, 680px);
    opacity: 0;
    transform: translateY(8px);
    transition: opacity 240ms ease, transform 240ms ease;
}

#metabolic-network-genome-cy.is-ready {
    opacity: 1;
    transform: translateY(0);
}

/* Standalone per-pathway reaction+metabolite graph (metabolism_pathway.html) -- same
   canvas treatment as the genome-wide unified graph, distinct id since it's a different
   page/JS entry point (metabolic-pathway-graph.js, not metabolic-network-genome.js). */
#metabolic-pathway-graph-cy {
    position: relative;
    z-index: 1;
    width: 100%;
    min-height: clamp(320px, 40vh, 500px);
    opacity: 0;
    transform: translateY(8px);
    transition: opacity 240ms ease, transform 240ms ease;
}

#metabolic-pathway-graph-cy.is-ready {
    opacity: 1;
    transform: translateY(0);
}

.metabolic-network-genome-loading {
    position: absolute;
    z-index: 2;
    top: 50%;
    left: 50%;
    display: inline-flex;
    align-items: center;
    gap: 9px;
    padding: 9px 16px;
    transform: translate(-50%, -50%);
    border: 1px solid var(--tp-color-border-soft);
    border-radius: 999px;
    background: color-mix(in srgb, var(--tp-color-surface) 92%, transparent);
    color: var(--tp-color-text-muted);
    font-size: 0.76rem;
    font-weight: 600;
    box-shadow: var(--tp-shadow-md);
    opacity: 1;
    transition: opacity 200ms ease;
    pointer-events: none;
}

#metabolic-network-genome-cy.is-ready ~ .metabolic-network-genome-loading,
#metabolic-pathway-graph-cy.is-ready ~ .metabolic-network-genome-loading {
    opacity: 0;
}

.metabolic-network-genome-spinner {
    display: inline-block;
    width: 13px;
    height: 13px;
    border: 2px solid var(--tp-color-border-strong);
    border-top-color: var(--tp-color-brand-500);
    border-radius: 999px;
    animation: metabolic-network-genome-spin 800ms linear infinite;
}

@keyframes metabolic-network-genome-spin {
    to { transform: rotate(360deg); }
}

@media (prefers-reduced-motion: reduce) {
    .metabolic-network-genome-spinner {
        animation: none;
    }
}

.metabolic-network-genome-hint {
    position: absolute;
    z-index: 2;
    left: 50%;
    bottom: 16px;
    transform: translateX(-50%);
    margin: 0;
    padding: 7px 14px;
    border: 1px solid var(--tp-color-border-soft);
    border-radius: 999px;
    background: color-mix(in srgb, var(--tp-color-surface) 94%, transparent);
    color: var(--tp-color-text-muted);
    font-size: 0.74rem;
    font-weight: 600;
    box-shadow: var(--tp-shadow-sm);
    opacity: 0;
    transition: opacity 260ms ease 200ms, transform 260ms ease 200ms;
    pointer-events: none;
}

.metabolic-network-genome-hint.is-visible {
    opacity: 1;
    transform: translateX(-50%) translateY(0);
}

.metabolic-network-genome-hint.is-dismissed {
    opacity: 0;
    transition-delay: 0s;
}

.metabolic-network-genome-score-bar {
    display: block;
    margin-top: 5px;
    width: 100%;
    height: 3px;
    border-radius: 999px;
    background: var(--tp-color-border-soft);
    overflow: hidden;
}

.metabolic-network-genome-score-fill {
    display: block;
    height: 100%;
    width: 0;
    border-radius: inherit;
    background: var(--tp-color-brand-500);
    opacity: 0.85;
    transition: width 320ms ease;
}

.metabolic-network-genome-note {
    position: relative;
    z-index: 1;
    margin: 0;
    padding: 8px 14px 10px;
    border-top: 1px solid var(--tp-color-border-soft);
    color: var(--tp-color-text-muted);
    background: var(--tp-color-surface);
    font-size: 0.75rem;
    line-height: 1.35;
}

.metabolic-map-btn {
    display: inline-flex;
    align-items: center;
    justify-content: center;
    min-width: 32px;
    height: 28px;
    padding: 0 10px;
    border: 1px solid var(--tp-color-border-strong);
    border-radius: 6px;
    background: var(--tp-color-surface);
    color: var(--tp-color-text-secondary);
    font-size: 0.76rem;
    font-weight: 700;
    line-height: 1;
    transition: border-color 140ms ease, background 140ms ease, color 140ms ease, transform 140ms ease;
}

.metabolic-map-btn:hover {
    border-color: var(--tp-color-brand-300);
    color: var(--tp-color-text-primary);
    background: var(--tp-color-surface-soft);
    transform: translateY(-1px);
}

.metabolic-network-genome-inspector {
    padding: 14px 16px;
    background: var(--tp-color-surface);
    display: flex;
    flex-direction: column;
    gap: 4px;
}

.metabolic-sidebar-title {
    display: block;
    margin-bottom: 9px;
    color: var(--tp-color-text-secondary);
    font-size: 0.68rem;
    font-weight: 700;
    letter-spacing: 0.08em;
    text-transform: uppercase;
}

.metabolic-network-genome-inspector strong {
    display: block;
    margin-bottom: 10px;
    color: var(--tp-color-text-primary);
    font-size: 0.92rem;
    line-height: 1.25;
    word-break: break-word;
}

.metabolic-network-genome-inspector dl {
    display: grid;
    grid-template-columns: 78px minmax(0, 1fr);
    gap: 7px 10px;
    margin: 0 0 12px;
}

.metabolic-network-genome-inspector dt {
    color: var(--tp-color-text-muted);
    font-size: 0.7rem;
    font-weight: 700;
    text-transform: uppercase;
}

.metabolic-network-genome-inspector dd {
    margin: 0;
    color: var(--tp-color-text-primary);
    font-size: 0.78rem;
    line-height: 1.35;
    word-break: break-word;
}

.metabolic-network-tooltip {
    position: absolute;
    z-index: 20;
    max-width: 340px;
    padding: 11px 12px;
    border: 1px solid var(--tp-color-border-strong);
    border-radius: 8px;
    background: color-mix(in srgb, var(--tp-color-surface) 96%, var(--tp-color-brand-050));
    color: var(--tp-color-text-primary);
    box-shadow: var(--tp-shadow-lg);
    font-size: 0.78rem;
    line-height: 1.35;
    pointer-events: none;
}

.metabolic-network-tooltip-title {
    display: flex;
    align-items: center;
    gap: 8px;
    margin-bottom: 8px;
    color: var(--tp-color-text-primary);
    font-size: 0.86rem;
    font-weight: 800;
}

.metabolic-network-tooltip-badge {
    display: inline-flex;
    align-items: center;
    padding: 2px 6px;
    border: 1px solid color-mix(in srgb, var(--tp-color-amber-500) 48%, transparent);
    border-radius: 999px;
    background: var(--tp-color-amber-050);
    color: var(--tp-color-amber-700);
    font-size: 0.68rem;
    font-weight: 800;
    white-space: nowrap;
}

.metabolic-network-tooltip dl {
    display: grid;
    grid-template-columns: 62px minmax(0, 1fr);
    gap: 4px 8px;
    margin: 0;
}

.metabolic-network-tooltip dt {
    color: var(--tp-color-text-muted);
    font-size: 0.68rem;
    font-weight: 800;
    text-transform: uppercase;
}

.metabolic-network-tooltip dd {
    margin: 0;
    color: var(--tp-color-text-primary);
    font-size: 0.76rem;
    word-break: break-word;
}

.metabolic-network-tooltip-hint {
    margin-top: 9px;
    padding-top: 8px;
    border-top: 1px solid var(--tp-color-border-soft);
    color: var(--tp-color-text-muted);
    font-size: 0.72rem;
}

@media (max-width: 860px) {
    .metabolic-network-genome-body {
        grid-template-columns: 1fr;
    }

    .metabolic-network-genome-canvas-wrap {
        border-right: 0;
        border-bottom: 1px solid var(--tp-color-border-soft);
    }
}