/* Metabolic pathways overview — hero reuses genome-overview.css as-is (same .genome-page/
   .genome-hero/.metric-pill classes); this file only covers the pathway ranking list below it. */

.metabolism-page {
    font-variant-numeric: tabular-nums;
}

.metric-pill--warm .metric-value {
    color: var(--tp-color-amber-700);
}

.metabolism-page h2,
.metabolism-page h3 {
    text-wrap: balance;
}

.metabolism-pathway-search {
    margin-top: 14px;
}

.metabolism-pathway-search .tp-ui-search-input {
    width: 100%;
}

#metabolism-pathway-empty.metabolism-pathway-search-empty {
    display: none;
    margin-top: 10px;
}

#metabolism-pathway-empty.metabolism-pathway-search-empty.is-visible {
    display: block;
}

.metabolism-pathway-list {
    display: flex;
    flex-direction: column;
    gap: 10px;
    margin-top: 16px;
}

.metabolism-pathway-card {
    display: grid;
    grid-template-columns: 28px 1fr;
    gap: 12px;
    padding: 14px 16px;
    border: 1px solid var(--tp-color-border-soft);
    border-radius: 10px;
    background: var(--tp-color-surface);
    box-shadow: var(--tp-shadow-xs);
    transition:
        border-color var(--tp-ui-motion-fast) var(--tp-ui-ease-standard),
        box-shadow var(--tp-ui-motion-fast) var(--tp-ui-ease-standard),
        transform var(--tp-ui-motion-fast) var(--tp-ui-ease-standard);
    animation: tp-ui-enter 340ms var(--tp-ui-ease-standard) both;
}

.metabolism-pathway-card:hover {
    border-color: var(--tp-color-border-strong);
    box-shadow: var(--tp-shadow-sm);
    transform: translateY(-1px);
}

.metabolism-rank {
    align-self: start;
    min-width: 28px;
    font-family: "JetBrains Mono", "SFMono-Regular", Menlo, Consolas, monospace;
    font-size: 0.95rem;
    font-weight: 600;
    color: var(--tp-color-text-muted);
}

.metabolism-pathway-card--top .metabolism-rank {
    color: var(--genome-accent-ink);
}

.metabolism-pathway-card--top {
    border-color: var(--tp-color-brand-200);
    background: var(--tp-color-brand-050);
}

.metabolism-pathway-card--top:hover {
    border-color: var(--tp-color-brand-300);
}

.metabolism-pathway-main {
    display: grid;
    grid-template-columns: minmax(0, 1.3fr) minmax(150px, 1fr);
    gap: 18px;
    align-items: start;
}

.metabolism-pathway-title {
    display: flex;
    align-items: baseline;
    gap: 8px;
    flex-wrap: wrap;
}

.metabolism-source {
    display: inline-flex;
    align-items: center;
    padding: 1px 7px;
    border-radius: 999px;
    background: var(--tp-color-brand-050);
    color: var(--tp-color-brand-900);
    font-size: 0.64rem;
    font-weight: 800;
    letter-spacing: 0.05em;
}

.metabolism-source--model {
    background: var(--tp-color-surface-muted);
    color: var(--tp-color-text-secondary);
}

.metabolism-pathway-title h3 {
    margin: 0;
    color: var(--genome-accent-ink);
    font-size: var(--tp-heading-sm);
    font-weight: 600;
    line-height: 1.2;
}

.metabolism-pathway-title h3 a {
    color: inherit;
    text-decoration: none;
}

.metabolism-pathway-title h3 a:hover {
    color: var(--tp-color-brand-800);
    text-decoration: underline;
    text-underline-offset: 3px;
}

.metabolism-pathway-id {
    margin: 3px 0 0;
    color: var(--tp-color-text-soft);
    font-size: 0.74rem;
}

.metabolism-stat-row {
    display: flex;
    gap: 18px;
    flex-wrap: wrap;
    margin-top: 10px;
}

.metabolism-stat {
    min-width: 60px;
}

.metabolism-stat-n {
    display: block;
    font-size: 0.9rem;
    font-weight: 600;
    color: var(--tp-color-text-primary);
    line-height: 1.2;
}

.metabolism-stat-n.is-warm {
    color: var(--tp-color-amber-700);
}

.metabolism-stat-l {
    display: block;
    margin-top: 1px;
    color: var(--tp-color-text-muted);
    font-size: 0.68rem;
    font-weight: 500;
    letter-spacing: 0.04em;
    text-transform: uppercase;
}

.metabolism-score-block {
    min-width: 130px;
}

.metabolism-score-label {
    display: block;
    color: var(--tp-color-text-muted);
    font-size: 0.68rem;
    font-weight: 500;
    letter-spacing: 0.04em;
    text-transform: uppercase;
}

.metabolism-score-n {
    display: inline-block;
    margin-top: 4px;
    padding: 5px 10px;
    border: 1px solid var(--genome-accent-border);
    border-radius: 8px;
    background: var(--genome-accent-soft);
    color: var(--genome-accent-ink);
    font-size: 0.9rem;
    font-weight: 600;
    line-height: 1;
}

.metabolism-score-sub {
    display: block;
    margin-top: 5px;
    color: var(--tp-color-text-muted);
    font-size: 0.72rem;
    font-weight: 600;
}

.metabolism-score-track {
    height: 4px;
    margin-top: 8px;
    border-radius: 3px;
    background: var(--tp-color-border-soft);
    overflow: hidden;
}

.metabolism-score-fill {
    height: 100%;
    border-radius: 3px;
    background: var(--genome-accent, var(--tp-color-brand-800));
}

.metabolism-target-strip {
    display: flex;
    flex-wrap: wrap;
    gap: 6px;
    margin-top: 12px;
}

.metabolism-card-actions {
    display: flex;
    justify-content: flex-end;
    gap: 8px;
    margin-top: 10px;
}

.metabolism-pathway-filter-form {
    display: contents;
}

.metabolism-target-chip {
    display: inline-flex;
    align-items: center;
    gap: 7px;
    padding: 6px 10px;
    border: 1px solid var(--tp-color-border-soft);
    border-radius: 9px;
    background: var(--tp-color-surface);
    color: var(--tp-color-text-primary);
    font-size: 0.78rem;
    text-decoration: none;
    transition: border-color 140ms ease, background 140ms ease, color 140ms ease, transform 140ms ease;
}

.metabolism-target-chip:hover {
    border-color: var(--tp-color-brand-300);
    text-decoration: none;
    transform: translateY(-1px);
}

.metabolism-target-chip--empty {
    color: var(--tp-color-text-muted);
    background: var(--tp-color-surface-muted);
    border-style: dashed;
    cursor: default;
}

.metabolism-target-chip--empty:hover {
    border-color: var(--tp-color-border-soft);
}

.metabolism-target-chip--top {
    border-color: var(--tp-color-brand-700);
    background: var(--tp-color-brand-050);
}

.metabolism-target-id {
    color: var(--tp-color-brand-800);
    font-size: 0.83rem;
    font-weight: 800;
}

.metabolism-target-chip--top .metabolism-target-id {
    color: var(--tp-color-brand-900);
}

.metabolism-connected-pathways {
    display: flex;
    flex-wrap: wrap;
    gap: 8px;
}

.metabolism-connected-pathway-chip {
    display: inline-flex;
    align-items: center;
    gap: 8px;
    padding: 7px 11px;
    border: 1px solid var(--tp-color-border-soft);
    border-radius: 9px;
    background: var(--tp-color-surface);
    color: var(--tp-color-text-primary);
    font-size: 0.82rem;
    font-weight: 600;
    text-decoration: none;
    transition: border-color 140ms ease, background 140ms ease, transform 140ms ease;
}

.metabolism-connected-pathway-chip:hover {
    border-color: var(--tp-color-brand-300);
    text-decoration: none;
    transform: translateY(-1px);
}

.metabolism-connected-pathway-weight {
    color: var(--tp-color-text-muted);
    font-size: 0.72rem;
    font-weight: 700;
}

.metabolism-target-meta {
    color: var(--tp-color-text-muted);
    font-size: 0.72rem;
}

.metabolism-chokepoint-dot {
    width: 6px;
    height: 6px;
    flex: 0 0 auto;
    border-radius: 999px;
    background: var(--tp-color-amber-500);
}

.metabolism-pathway-detail-page .metabolism-panel {
    margin-top: 16px;
    box-shadow: var(--tp-shadow-sm);
}

.metabolism-pathway-detail-page .genome-hero-eyebrow,
.metabolism-pathway-detail-page .genome-hero h1,
.metabolism-pathway-detail-page .genome-description,
.metabolism-pathway-detail-page .genome-hero-actions,
.metabolism-pathway-detail-page .genome-metrics {
    animation: tp-ui-enter 340ms var(--tp-ui-ease-standard) both;
}

.metabolism-pathway-detail-page .genome-hero h1 { animation-delay: 40ms; }
.metabolism-pathway-detail-page .genome-description { animation-delay: 80ms; }
.metabolism-pathway-detail-page .genome-hero-actions { animation-delay: 120ms; }
.metabolism-pathway-detail-page .genome-metrics { animation-delay: 160ms; }

.metabolism-pathway-detail-page .genome-metrics .metric-pill {
    transition:
        transform var(--tp-ui-motion-fast) var(--tp-ui-ease-standard),
        box-shadow var(--tp-ui-motion-fast) var(--tp-ui-ease-standard),
        border-color var(--tp-ui-motion-fast) var(--tp-ui-ease-standard);
}

.metabolism-pathway-detail-page .genome-metrics .metric-pill:hover {
    transform: translateY(-1px);
    box-shadow: var(--tp-shadow-sm);
    border-color: var(--tp-color-border-strong);
}

.metabolism-pathway-detail-page .pathway-reaction-row {
    animation: tp-ui-enter 340ms var(--tp-ui-ease-standard) both;
}

.metabolism-reaction-table .pathway-reaction-row:nth-child(1) { animation-delay: 0ms; }
.metabolism-reaction-table .pathway-reaction-row:nth-child(2) { animation-delay: 28ms; }
.metabolism-reaction-table .pathway-reaction-row:nth-child(3) { animation-delay: 56ms; }
.metabolism-reaction-table .pathway-reaction-row:nth-child(4) { animation-delay: 84ms; }
.metabolism-reaction-table .pathway-reaction-row:nth-child(5) { animation-delay: 112ms; }
.metabolism-reaction-table .pathway-reaction-row:nth-child(6) { animation-delay: 140ms; }
.metabolism-reaction-table .pathway-reaction-row:nth-child(7) { animation-delay: 168ms; }
.metabolism-reaction-table .pathway-reaction-row:nth-child(8) { animation-delay: 196ms; }
.metabolism-reaction-table .pathway-reaction-row:nth-child(9) { animation-delay: 224ms; }
.metabolism-reaction-table .pathway-reaction-row:nth-child(10) { animation-delay: 252ms; }
.metabolism-reaction-table .pathway-reaction-row:nth-child(11) { animation-delay: 280ms; }
.metabolism-reaction-table .pathway-reaction-row:nth-child(12) { animation-delay: 308ms; }
.metabolism-reaction-table .pathway-reaction-row:nth-child(13) { animation-delay: 336ms; }
.metabolism-reaction-table .pathway-reaction-row:nth-child(14) { animation-delay: 364ms; }
.metabolism-reaction-table .pathway-reaction-row:nth-child(n+15) { animation-delay: 392ms; }

.metabolism-pathway-map-shell {
    position: relative;
    overflow: hidden;
    border: 1px solid var(--tp-color-border-soft);
    border-radius: 8px;
    background: var(--tp-color-surface);
}

.metabolic-pathway-map-tooltip {
    position: absolute;
    z-index: 20;
    max-width: 320px;
    padding: 11px 12px;
    border: 1px solid var(--tp-color-border-strong);
    border-radius: 8px;
    background: color-mix(in srgb, var(--tp-color-surface) 96%, var(--tp-color-brand-050));
    color: var(--tp-color-text-primary);
    box-shadow: var(--tp-shadow-lg);
    pointer-events: none;
}

.metabolic-pathway-map-tooltip .metabolic-network-tooltip-title {
    display: flex;
    align-items: center;
    gap: 8px;
    margin-bottom: 8px;
    font-size: 0.86rem;
    font-weight: 800;
}

.metabolic-pathway-map-tooltip .metabolic-network-tooltip-badge {
    display: inline-flex;
    align-items: center;
    padding: 2px 6px;
    border: 1px solid color-mix(in srgb, var(--tp-color-amber-500) 48%, transparent);
    border-radius: 999px;
    background: var(--tp-color-amber-050);
    color: var(--tp-color-amber-700);
    font-size: 0.68rem;
}

.metabolic-pathway-map-tooltip dl {
    display: grid;
    grid-template-columns: 62px minmax(0, 1fr);
    gap: 4px 8px;
    margin: 0;
}

.metabolic-pathway-map-tooltip dt {
    color: var(--tp-color-text-muted);
    font-size: 0.68rem;
    font-weight: 800;
    text-transform: uppercase;
}

.metabolic-pathway-map-tooltip dd {
    margin: 0;
    color: var(--tp-color-text-primary);
    font-size: 0.76rem;
    word-break: break-word;
}

.metabolic-pathway-map-tooltip .metabolic-network-tooltip-hint {
    margin-top: 9px;
    padding-top: 8px;
    border-top: 1px solid var(--tp-color-border-soft);
    color: var(--tp-color-text-muted);
    font-size: 0.72rem;
}

.metabolism-pathway-map-toolbar {
    display: flex;
    align-items: center;
    justify-content: space-between;
    gap: 12px;
    padding: 10px 12px;
    border-bottom: 1px solid var(--tp-color-border-soft);
    background: var(--tp-color-surface-soft);
}

.metabolism-pathway-map-legend {
    display: flex;
    flex-wrap: wrap;
    gap: 10px 16px;
    color: var(--tp-color-text-secondary);
    font-size: 0.76rem;
    font-weight: 700;
}

.metabolism-pathway-map-legend span {
    display: inline-flex;
    align-items: center;
    gap: 6px;
}

.metabolism-pathway-map-actions {
    display: inline-flex;
    align-items: center;
    gap: 6px;
    flex: 0 0 auto;
}

.metabolism-pathway-map-actions .metabolic-map-btn {
    display: inline-flex;
    align-items: center;
    justify-content: center;
    min-width: 32px;
    height: 28px;
    padding: 0 10px;
    border: 1px solid var(--tp-color-border-strong);
    border-radius: 6px;
    background: var(--tp-color-surface);
    color: var(--tp-color-text-secondary);
    font-size: 0.76rem;
    font-weight: 800;
    line-height: 1;
    transition: border-color 140ms ease, background 140ms ease, color 140ms ease, transform 140ms ease;
}

.metabolism-pathway-map-actions .metabolic-map-btn:hover {
    border-color: var(--tp-color-brand-300);
    color: var(--tp-color-text-primary);
    background: var(--tp-color-surface-soft);
    transform: translateY(-1px);
}

.map-legend-box,
.map-legend-dot {
    width: 12px;
    height: 12px;
    flex: 0 0 auto;
    border: 1px solid var(--tp-color-border-strong);
}

.map-legend-box {
    border-radius: 3px;
    background: var(--tp-color-brand-050);
    border-color: var(--tp-color-brand-700);
}

.map-legend-box--chokepoint {
    background: var(--tp-color-amber-050);
    border-color: var(--tp-color-amber-500);
}

.map-legend-dot {
    border-radius: 999px;
    background: var(--tp-color-sage-500);
    border-color: var(--tp-color-surface);
}

.map-legend-dot--currency {
    background: var(--tp-color-text-soft);
    opacity: 0.7;
}

.metabolic-pathway-diagram {
    min-height: 520px;
    overflow: auto;
    cursor: default;
}

.metabolic-pathway-diagram svg {
    display: block;
    min-width: 960px;
    width: 100%;
    transition: opacity 220ms ease;
    animation: tp-metabolism-map-in 280ms ease both;
}

.metabolic-pathway-diagram.is-empty {
    display: flex;
    align-items: center;
    justify-content: center;
    min-height: 320px;
    color: var(--tp-color-text-muted);
    font-size: 0.9rem;
}

.pathway-map-axis {
    fill: var(--tp-color-text-muted);
    font-size: 12px;
    font-weight: 800;
    letter-spacing: 0.08em;
    text-transform: uppercase;
}

.pathway-map-reaction-label {
    fill: var(--tp-color-text-primary);
    font-size: 12.5px;
    font-weight: 800;
}

.pathway-map-gene-label {
    fill: var(--tp-color-text-secondary);
    font-size: 10.5px;
    font-weight: 700;
}

.pathway-map-gene-label.is-muted-label {
    fill: var(--tp-color-text-muted);
    font-weight: 600;
    font-style: italic;
}

.pathway-map-gene-link {
    cursor: pointer;
}

.pathway-map-gene-link .pathway-map-gene-label {
    text-decoration: underline;
    text-decoration-color: transparent;
    transition: fill 140ms ease, text-decoration-color 140ms ease;
}

.pathway-map-gene-link:hover .pathway-map-gene-label {
    fill: var(--tp-color-brand-700);
    text-decoration-color: var(--tp-color-brand-300);
}

.pathway-map-metabolite-dot {
    cursor: pointer;
    transition: r 140ms ease, opacity 140ms ease;
}

.pathway-map-metabolite-dot:hover {
    opacity: 1;
}

.pathway-map-shared-label {
    fill: var(--tp-color-sage-700);
    font-size: 10.5px;
    font-weight: 800;
}

.pathway-map-metabolite {
    fill: var(--tp-color-text-primary);
    font-size: 11.5px;
    font-weight: 650;
}

.pathway-map-metabolite.is-currency {
    fill: var(--tp-color-text-muted);
    font-weight: 500;
}

.pathway-map-row {
    transition: opacity 140ms ease;
}

.pathway-map-row rect,
.pathway-map-row path,
.pathway-map-row circle {
    transition: opacity 140ms ease, stroke-width 140ms ease, filter 140ms ease;
}

.pathway-map-row:hover > rect:first-of-type {
    filter: brightness(0.985);
}

.pathway-map-row:hover text {
    font-weight: 800;
}

.metabolic-provenance {
    margin: 10px 0 0;
    color: var(--tp-color-text-soft);
    font-size: var(--tp-font-label);
}

.metabolism-reaction-table {
    display: flex;
    flex-direction: column;
    gap: 10px;
}

.pathway-reaction-row {
    padding: 14px;
    border: 1px solid var(--tp-color-border-soft);
    border-radius: 8px;
    background: var(--tp-color-surface);
    box-shadow: var(--tp-shadow-xs);
    transition: border-color 140ms ease, box-shadow 140ms ease, transform 140ms ease;
}

.pathway-reaction-row--chokepoint {
    border-color: color-mix(in srgb, var(--tp-color-amber-500) 42%, var(--tp-color-border-soft));
}

.pathway-reaction-row:hover {
    border-color: var(--tp-color-border-strong);
    box-shadow: var(--tp-shadow-lg);
    transform: translateY(-1px);
}

.pathway-reaction-row .target-evidence-accessory-badge {
    display: inline-flex;
    align-items: center;
    width: fit-content;
    padding: 3px 9px;
    border: 1px solid color-mix(in srgb, var(--tp-color-amber-500) 38%, transparent);
    border-radius: 999px;
    background: var(--tp-color-amber-050);
    color: var(--tp-color-amber-700);
    font-size: 0.72rem;
    font-weight: 800;
    line-height: 1.2;
}

.pathway-reaction-main {
    display: flex;
    align-items: flex-start;
    justify-content: space-between;
    gap: 12px;
}

.pathway-reaction-main h3 {
    margin: 0;
    color: var(--tp-color-text-primary);
    font-family: "JetBrains Mono", "SFMono-Regular", Menlo, Consolas, monospace;
    font-size: 0.88rem;
    font-weight: 700;
}

.pathway-reaction-main p {
    margin: 3px 0 0;
    color: var(--tp-color-text-muted);
    font-size: 0.78rem;
}

.reaction-external-link {
    color: var(--tp-color-brand-700);
    font-weight: 800;
    text-decoration: underline;
    text-decoration-thickness: 1px;
    text-underline-offset: 3px;
}

.reaction-external-link::after {
    margin-left: 5px;
    padding: 1px 4px;
    border: 1px solid var(--tp-color-brand-200);
    border-radius: 5px;
    font-size: 0.64em;
    letter-spacing: 0.04em;
    text-decoration: none;
}

.reaction-external-link--kegg::after {
    content: "KEGG";
}

.reaction-external-link--metacyc::after {
    content: "MetaCyc";
}

.reaction-external-link:hover {
    color: var(--tp-color-brand-900);
}

.pathway-reaction-equation {
    /* Content-hugging flex, not a stretched 1fr/auto/1fr grid -- a reaction with one
       substrate and one product otherwise left a large dead gap between the chip and
       the arrow, since the grid columns always spanned the full row width regardless
       of how little content was in them. */
    display: flex;
    flex-wrap: wrap;
    align-items: center;
    gap: 10px;
    margin-top: 10px;
}

.pathway-reaction-equation > div {
    display: flex;
    flex-wrap: wrap;
    align-items: center;
    gap: 6px;
    min-width: 0;
}

.pathway-reaction-genes {
    display: flex;
    flex-wrap: wrap;
    gap: 6px;
}

.metabolite-chip {
    display: inline-flex;
    align-items: center;
    min-width: 0;
    max-width: 220px;
    padding: 3px 8px;
    border: 1px solid var(--tp-color-border-soft);
    border-radius: 999px;
    background: var(--tp-color-surface-soft);
    color: var(--tp-color-text-primary);
    font-size: 0.74rem;
    font-weight: 650;
    line-height: 1.25;
    overflow: hidden;
    vertical-align: middle;
    transition: border-color 140ms ease, background 140ms ease, color 140ms ease, transform 140ms ease;
}

.metabolite-chip:hover {
    border-color: var(--tp-color-brand-300);
    background: var(--tp-color-brand-050);
    transform: translateY(-1px);
}

.metabolite-chip-label {
    display: block;
    min-width: 0;
    overflow: hidden;
    text-overflow: ellipsis;
    white-space: nowrap;
}

.metabolite-chip.is-currency {
    color: var(--tp-color-text-muted);
    background: var(--tp-color-surface-muted);
    font-weight: 500;
}

.metabolite-arrow {
    color: var(--tp-color-text-muted);
    font-size: 0.88rem;
    font-weight: 800;
}

.metabolite-arrow--reversible {
    color: var(--tp-color-sage-700);
}

.pathway-reaction-genes {
    margin-top: 10px;
}

@keyframes tp-metabolism-map-in {
    from {
        opacity: 0;
        transform: scale(0.992);
    }
    to {
        opacity: 1;
        transform: none;
    }
}

@keyframes tp-metabolism-row-fade {
    from { opacity: 0; }
    to { opacity: 1; }
}

.pathway-map-row {
    animation: tp-metabolism-row-fade 300ms ease both;
}

@media (prefers-reduced-motion: reduce) {
    .metabolism-pathway-card,
    .metabolic-pathway-diagram svg,
    .metabolism-pathway-detail-page .genome-hero-eyebrow,
    .metabolism-pathway-detail-page .genome-hero h1,
    .metabolism-pathway-detail-page .genome-description,
    .metabolism-pathway-detail-page .genome-hero-actions,
    .metabolism-pathway-detail-page .genome-metrics,
    .metabolism-pathway-detail-page .pathway-reaction-row,
    .pathway-map-row {
        animation: none;
    }

    .metabolism-pathway-card,
    .metabolism-target-chip,
    .pathway-reaction-row,
    .metabolite-chip,
    .metabolism-pathway-detail-page .genome-metrics .metric-pill {
        transition: none;
    }
}

@media (max-width: 1100px) {
    .metabolism-pathway-main {
        grid-template-columns: 1fr;
    }
}

@media (max-width: 720px) {
    .metabolism-stat-row {
        gap: 14px;
    }

    .metabolism-pathway-title {
        align-items: flex-start;
        flex-direction: column;
        gap: 4px;
    }

    .metabolism-card-actions {
        justify-content: flex-start;
    }

    .pathway-reaction-main {
        display: grid;
        grid-template-columns: 1fr;
    }
}