Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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5081 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3501 VK055_3324 aspartate--ammonia ligase asnA AlphaFold + ColabFold
6.3.1.1
GO:0006529OBSOLETE. The chemical reactions and pathways resulting in the formation of asparagine, 2-amino-3-carbamoylpropanoic acid. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004071Catalysis of the reaction: ATP + L-aspartate + NH4+ = AMP + diphosphate + L-asparagine. +36 total
0.391 No Hit 0.0% —
3502 VK055_2251 receptor ligand binding region family protein AlphaFold + ColabFold – – 0.391 No Hit 0.0% —
3503 VK055_1994 helix-turn-helix domain protein AlphaFold + ColabFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.391 No Hit 0.0% —
3504 VK055_1609 glutaredoxin, GrxA family grxA AlphaFold + ColabFold –
GO:0015035Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. GO:0009055A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0045454Any process that maintains the redox environment of a cell or compartment within a cell. +47 total
0.391 Hit 32.1% 1.21e-07
3505 VK055_0667 sugar (and other) transporter family protein AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
0.391 Hit 28.3% 1.92e-09
3506 VK055_0561 alpha/beta hydrolase fold family protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0047372Catalysis of the reaction: a monoacylglycerol + H2O = a fatty acid + glycerol + H+. GO:0046464The chemical reactions and pathways resulting in the breakdown of acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids.
0.391 Hit 50.0% 1.58e-07
3507 VK055_0455 binding-protein-dependent transport system innermembrane component family protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.391 No Hit 0.0% —
3508 VK055_0210 sulfate permease family protein sulP AlphaFold + ColabFold –
GO:0008272OBSOLETE. The directed movement of sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
0.391 Hit 35.2% 1.00e-22
3509 VK055_3844 peptidase Do family protein AlphaFold + ColabFold
3.4.21.107
GO:0004252Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0005515Binding to a protein. +25 total
0.39 Hit 41.4% 9.20e-29
3510 VK055_2500 3-dehydroquinate dehydratase aroD AlphaFold + ColabFold
4.2.1.10
GO:0003855Catalysis of the reaction: 3-dehydroquinate = 3-dehydroshikimate + H2O. GO:0046279The chemical reactions and pathways resulting in the formation of 3,4-dihydroxybenzoate. GO:0008652The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. +25 total
0.39 No Hit 0.0% —
3511 VK055_2188 riboflavin biosynthesis protein RibD ribD AlphaFold + ColabFold –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0009231The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). GO:0008270Binding to a zinc ion (Zn). +47 total
0.39 No Hit 0.0% —
3512 VK055_0514 electron transport complex, RnfABCDGE type, A subunit AlphaFold + ColabFold –
GO:0022900A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.39 No Hit 0.0% —
3513 VK055_4771 putative oxidoreductase AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0051596The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid.
0.389 Hit 40.7% 1.52e-06
3514 VK055_1270 ahpC/TSA family protein AlphaFold + ColabFold –
GO:0006979Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. GO:0004602Catalysis of the reaction: 2 glutathione + H2O2 = oxidized glutathione + 2 H2O.
0.389 Hit 53.9% 2.04e-18
3515 VK055_4976 phosphomethylpyrimidine kinase thiD AlphaFold + ColabFold
2.7.1.49
GO:0009228The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. GO:0008972Catalysis of the reaction: ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine = ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +36 total
0.388 No Hit 0.0% —
3516 VK055_2504 hypothetical protein AlphaFold + ColabFold – – 0.388 No Hit 0.0% —
3517 VK055_0269 YCII-related domain protein AlphaFold + ColabFold – – 0.388 No Hit 0.0% —
3518 VK055_0014 putative outer membrane protein N AlphaFold + ColabFold –
GO:0051301The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
0.388 No Hit 0.0% —
3519 VK055_4104 methionine adenosyltransferase metK AlphaFold + ColabFold
2.5.1.6
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006556The chemical reactions and pathways resulting in the formation of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism. GO:0004478Catalysis of the reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine. +36 total
0.387 Hit 58.2% 3.00e-144
3520 VK055_3687 iron-sulfur cluster scaffold protein gntY AlphaFold + ColabFold –
GO:0016226The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. GO:0005506Binding to an iron (Fe) ion. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. +25 total
0.387 No Hit 0.0% —
3521 VK055_3489 dut dut AlphaFold + ColabFold
3.6.1.23
GO:0046081The chemical reactions and pathways resulting in the breakdown of dUTP, deoxyuridine (5'-)triphosphate. GO:0006226The chemical reactions and pathways resulting in the formation of dUMP, deoxyuridine monophosphate (2'-deoxyuridine 5'-phosphate). GO:0000287Binding to a magnesium (Mg) ion. +14 total
0.387 Hit 37.8% 1.63e-10
3522 VK055_2555 riboflavin biosynthesis protein RibF ribF AlphaFold + ColabFold –
GO:0003919Catalysis of the reaction: ATP + FMN = diphosphate + FAD. GO:0009231The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). GO:0008531Catalysis of the reaction: ATP + riboflavin = ADP + FMN + 2 H+. +36 total
0.387 No Hit 0.0% —
3523 VK055_2291 hypothetical protein AlphaFold + ColabFold – – 0.387 No Hit 0.0% —
3524 VK055_1854 hypothetical protein ColabFold – – 0.387 No Hit 0.0% —
3525 VK055_1605 bacterial sensory transduction regulator family protein AlphaFold + ColabFold – – 0.387 No Hit 0.0% —
Page of 204 · 5081 total proteins