Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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5081 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4251 VK055_4156 putative folate-dependent regulatory protein AlphaFold + ColabFold –
GO:0005542Binding to folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines. GO:0009451The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
0.253 No Hit 0.0% —
4252 VK055_4103 MFS transporter, sugar porter family protein AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +36 total
0.253 Hit 37.6% 1.25e-12
4253 VK055_3990 bacterial regulatory, luxR family protein AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.
0.252 No Hit 0.0% —
4254 VK055_3104 hypothetical protein AlphaFold + ColabFold – – 0.252 No Hit 0.0% —
4255 VK055_4905 16S rRNA pseudouridine 516 synthase rsuA AlphaFold + ColabFold
5.4.99.-
GO:0016866Catalysis of the transfer of a functional group from one position to another within a single molecule. GO:0009451The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. GO:0003723Binding to an RNA molecule or a portion thereof. +58 total
0.251 No Hit 0.0% —
4256 VK055_4029 hypothetical protein Experimental + ColabFold – – 0.251 No Hit 0.0% —
4257 VK055_3694 putative transcriptional accessory protein AlphaFold + ColabFold –
GO:0006139Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. GO:0003676Binding to a nucleic acid. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +36 total
0.251 Hit 37.9% 9.04e-07
4258 VK055_1598 response regulator AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. +47 total
0.251 No Hit 0.0% —
4259 VK055_1049 ynbE-like lipofamily protein AlphaFold + ColabFold – – 0.251 No Hit 0.0% —
4260 VK055_0818 melibiase family protein AlphaFold + ColabFold – – 0.251 No Hit 0.0% —
4261 VK055_0043 hypothetical protein AlphaFold + ColabFold – – 0.251 No Hit 0.0% —
4262 VK055_4622 response regulator yfhA AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0008134Binding to a transcription factor, a protein required to initiate or regulate transcription. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. +36 total
0.25 No Hit 0.0% —
4263 VK055_4525 NADH-azoreductase, FMN-dependent Experimental + ColabFold –
GO:0016655Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule. GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
0.25 No Hit 0.0% —
4264 VK055_3634 sirA-like family protein AlphaFold + ColabFold –
GO:0002143The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps. GO:0097163Covalently binding to sulfur and delivering it to an acceptor molecule. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
0.25 No Hit 0.0% —
4265 VK055_1378 ribosomal protein L32 rpmF ColabFold –
GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. GO:0015934The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site).
0.25 No Hit 0.0% —
4266 VK055_1747 hypothetical protein ColabFold – – 0.249 No Hit 0.0% —
4267 VK055_4795 mepA mepA AlphaFold + ColabFold
3.4.24.-
GO:0004252Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. +36 total
0.248 No Hit 0.0% —
4268 VK055_4680 bacterial regulatory helix-turn-helix, lysR family protein AlphaFold + ColabFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
0.248 No Hit 0.0% —
4269 VK055_4437 periplasmic binding and sugar binding domain of LacI family protein AlphaFold + ColabFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +14 total
0.248 No Hit 0.0% —
4270 VK055_3732 osmC-like family protein AlphaFold + ColabFold – – 0.248 No Hit 0.0% —
4271 VK055_3562 3-methyladenine DNA glycosylase I tag AlphaFold + ColabFold
3.2.2.20
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0006281The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. GO:0006284In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. +25 total
0.248 No Hit 0.0% —
4272 VK055_2538 citrate lyase, alpha subunit citF AlphaFold + ColabFold
2.8.3.10 4.1.3.6
GO:0006084The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis. GO:0008814Catalysis of the reaction: acetyl-CoA + citrate = acetate + (3S)-citryl-CoA. GO:0009346Citrate lyase is a multienzyme complex with three constituents: the alpha subunit, citrate-ACP transferase; the beta subunit, citryl-ACP lyase; and the gamma subunit, an acyl-carrier protein which also carries the prosthetic group components. All three subunits are required for citrate lyase enzyme activity. This enzyme has only been found in bacteria. +25 total
0.248 No Hit 0.0% —
4273 VK055_2366 ldcC AlphaFold + ColabFold
4.1.1.18
GO:0006520The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0016831Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. +69 total
0.248 No Hit 0.0% —
4274 VK055_1323 adenylosuccinate lyase purB AlphaFold + ColabFold
4.3.2.2
GO:0006188The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0004018Catalysis of the reaction: N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP. +58 total
0.248 Hit 23.2% 5.01e-07
4275 VK055_0803 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 family protein AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. GO:0090563Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + sugar(out) = protein cysteine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. +14 total
0.248 No Hit 0.0% —
Page of 204 · 5081 total proteins