Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2151 KP13_05473 hypothetical protein AlphaFold + ColabFold – – 0.668 No Hit 0.0% —
2152 KP13_04993 N-succinylglutamate 5-semialdehyde dehydrogenase astD AlphaFold + ColabFold
1.2.1.71
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0006527The chemical reactions and pathways resulting in the breakdown of L-arginine. GO:0016620Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. +36 total
0.668 Hit 34.6% 4.95e-06
2153 KP13_04897 Peptidoglycan-binding lysin domain-containing protein AlphaFold + ColabFold
2.-.-.-
GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. GO:0005576The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). +58 total
0.668 No Hit 0.0% —
2154 KP13_04869 Virulence transcriptional regulatory protein phoP phoP AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.668 No Hit 0.0% —
2155 KP13_04321 ATP-dependent RNA helicase rhlE rhlE AlphaFold + ColabFold
3.6.4.13
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0003676Binding to a nucleic acid. GO:0042255The aggregation, arrangement and bonding together of the mature ribosome and of its subunits. +47 total
0.668 Hit 52.5% 1.77e-12
2156 KP13_03402 Enterobactin exporter entS entS AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0042931Enables the directed movement of the siderochrome enterochelin, a cyclic trimer of 2, 3 dihydroxybenzoylserine from one side of a membrane to the other. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. +14 total
0.668 No Hit 0.0% —
2157 KP13_03360 hypothetical protein AlphaFold + ColabFold –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0071453Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen.
0.668 No Hit 0.0% —
2158 KP13_01403 hypothetical protein AlphaFold + ColabFold – – 0.668 No Hit 0.0% —
2159 KP13_00455 Protein phnH phnH AlphaFold + ColabFold –
GO:0019634The chemical reactions and pathways involving phosphonates, any organic compounds containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Metabolism of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included. GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
0.668 No Hit 0.0% —
2160 KP13_06711 hypothetical protein AlphaFold + ColabFold – – 0.667 No Hit 0.0% —
2161 KP13_05543 putative lactonase AlphaFold + ColabFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0046872Binding to a metal ion.
0.667 No Hit 0.0% —
2162 KP13_04762 hypothetical protein AlphaFold + ColabFold – – 0.667 No Hit 0.0% —
2163 KP13_04281 Glutathione transport system permease protein gsiD gsiD AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
0.667 No Hit 0.0% —
2164 KP13_03378 HTH-type transcriptional repressor purR purR AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +14 total
0.667 No Hit 0.0% —
2165 KP13_06661 hypothetical protein ColabFold – – 0.666 No Hit 0.0% —
2166 KP13_04632 FeS cluster assembly protein sufB sufB AlphaFold + ColabFold –
GO:0016226The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster.
0.666 No Hit 0.0% —
2167 KP13_01753 hypothetical protein AlphaFold + ColabFold – – 0.666 No Hit 0.0% —
2168 KP13_01525 High-affinity branched-chain amino acid transport ATP-binding protein braG braG AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0015658Enables the transfer of branched-chain amino acids from one side of a membrane to the other. Branched-chain amino acids are amino acids with a branched carbon skeleton without rings. +14 total
0.666 Hit 34.4% 4.84e-09
2169 KP13_01077 Ribosomal RNA small subunit methyltransferase I rsmI AlphaFold + ColabFold –
GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule.
0.666 No Hit 0.0% —
2170 KP13_04488 Putative transcriptional regulator AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +14 total
0.665 No Hit 0.0% —
2171 KP13_04190 kinase-like domain-containing protein AlphaFold + ColabFold – – 0.665 No Hit 0.0% —
2172 KP13_03725 hypothetical protein AlphaFold + ColabFold – – 0.665 No Hit 0.0% —
2173 KP13_02092 Extensin-like protein AlphaFold + ColabFold – – 0.665 No Hit 0.0% —
2174 KP13_00820 hypothetical protein AlphaFold + ColabFold
3.1.3.27
GO:0046872Binding to a metal ion. GO:0008962Catalysis of the reaction: phosphatidylglycerophosphate + H2O = phosphatidylglycerol + phosphate.
0.665 No Hit 0.0% —
2175 KP13_00330 Undecaprenyl phosphate-aminoarabinose flippase subunit ArnF arnF AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009103The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. GO:1901505Enables the transfer of carbohydrate derivative from one side of a membrane to the other. +14 total
0.665 No Hit 0.0% —
Page of 234 · 5842 total proteins