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Human curated protein

P35318

Pro-adrenomedullin

Gene: ADM Organism: Homo sapiens Reviewed UniProt
All human targets
Length 185 aa
Mass 20,420 Da
Annotation score 5/5
Entry version 209
Ligand records 150

Overview

Peptide hormone that act as potent hypotensive and vasodilatator agents by inhibiting catecholamine secretion from sympathetic nerve endings and adrenal chromaffin cells (PubMed:10588445, PubMed:9578982).

Publications

Function

Molecular function, catalytic activity, and Gene Ontology annotations.

0 EC 6 GO

Peptide hormone that act as potent hypotensive and vasodilatator agents by inhibiting catecholamine secretion from sympathetic nerve endings and adrenal chromaffin cells (PubMed:10588445, PubMed:9578982). Acts as a ligand for MRGPRX2 receptor in mast cells (PubMed:15823563, PubMed:34789875)

Biological process

adenylate cyclase-activating G protein-coupled receptor signaling pathway adrenomedullin receptor signaling pathway branching involved in labyrinthine layer morphogenesis cell population proliferation developmental growth G protein-coupled receptor internalization heart development inflammatory response negative regulation of vascular permeability negative regulation of vasoconstriction neural tube closure positive regulation of angiogenesis positive regulation of cell population proliferation positive regulation of heart rate positive regulation of progesterone biosynthetic process positive regulation of vasculogenesis receptor internalization regulation of systemic arterial blood pressure regulation of urine volume signal transduction vascular associated smooth muscle cell development vasculogenesis

Cellular component

cytoplasm extracellular region extracellular space secretory granule lumen

Molecular function

adrenomedullin receptor binding hormone activity signaling receptor binding

Sequence

185 amino acids

MKLVSVALMYLGSLAFLGADTARLDVASEFRKKWNKWALSRGKRELRMSSSYPTGLADVKAGPAQTLIRPQDMKGASRSPEDSSPDAARIRVKRYRQSMNNFQGLRSFGCRFGTCTVQKLAHQIYQFTDKDKDNVAPRSKISPQGYGRRRRRSLPEAGPGRTLVSSKPQAHGAPAPPSGSAPHFL
Signal
1–21 —
Region
60–87 Disordered
133–185 Disordered
Disulfide bond
110–115 —

Ligand evidence

Ligands grouped by evidence source, via the same LigQ_2 pipeline used across Target.

150 records
Chemistry signal

Bioactivity evidence is available for this target.

Direct evidence 0 same-protein records
Transferred evidence 100 records from similar proteins
Structural ligands 0 0 loaded crystals
Measured bioactivity 100 direct and transferred ChEMBL records
Proposed compounds 50 similarity-based ZINC candidates
Show only:
Ligand UniProt (homolog) pchembl MW · LogP · TPSA Lipinski PAINS SMILES
CHEMBL1910953 ChEMBL P06881 11.00 ~0.0 nM 3791.4 Da LogP -22.52 TPSA 1620.6 3 viol. ✓ Clean CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC…
CHEMBL207197 ChEMBL P06881 10.85 ~0.0 nM 869.7 Da LogP 4.41 TPSA 176.5 1 viol. ✓ Clean NCCCC[C@H](NC(=O)[C@@H](Cc1cc(Br)c(O)c(Br)c1)NC…
CHEMBL1910936 ChEMBL P06881 10.62 ~0.0 nM 557.6 Da LogP 3.77 TPSA 103.4 1 viol. ✓ Clean O=C(CN1C(=O)C2(CCCC2)NC[C@H]1c1cc(F)cc(F)c1)Nc1…
CHEMBL525962 ChEMBL P06881 10.30 ~0.1 nM 3789.4 Da LogP -21.99 TPSA 1620.6 3 viol. ✓ Clean CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC…
CHEMBL5749175 ChEMBL P06881 10.30 ~0.1 nM 734.9 Da LogP 3.90 TPSA 196.3 1 viol. ✓ Clean Cc1cc(C[C@@H](NC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)C…
CHEMBL6063368 ChEMBL P06881 10.30 ~0.1 nM 689.9 Da LogP 4.81 TPSA 146.1 1 viol. ✓ Clean Cc1cc(C[C@@H](NC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)C…
CHEMBL503773 ChEMBL P06881 10.22 ~0.1 nM 3426.0 Da LogP -12.05 TPSA 1345.1 3 viol. ✓ Clean CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=…
CHEMBL5802075 ChEMBL P06881 10.20 ~0.1 nM 762.9 Da LogP 4.38 TPSA 185.3 1 viol. ✓ Clean CCOC(=O)c1nnc(C2CCN(C3CCN(C(=O)[C@@H](Cc4cc(C)c…
CHEMBL5766309 ChEMBL P06881 10.10 ~0.1 nM 703.9 Da LogP 5.12 TPSA 146.1 2 viol. ✓ Clean Cc1nc[nH]c1C1CCN(C2CCN(C(=O)[C@@H](Cc3cc(C)c4[n…
CHEMBL5759208 ChEMBL P06881 10.00 ~0.1 nM 704.9 Da LogP 4.51 TPSA 159.0 1 viol. ✓ Clean Cc1nnc(C2CCN(C3CCN(C(=O)[C@@H](Cc4cc(C)c5[nH]nc…
CHEMBL5991982 ChEMBL P06881 10.00 ~0.1 nM 704.9 Da LogP 4.21 TPSA 148.1 1 viol. ✓ Clean Cc1cc(C[C@@H](NC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)C…
CHEMBL3771371 ChEMBL P06881 9.96 ~0.1 nM 631.8 Da LogP 5.87 TPSA 108.4 2 viol. ✓ Clean Cc1cc(C[C@@H](NC(=O)N2CCC(c3cc4ccccc4cc3C#N)CC2…
CHEMBL5870955 ChEMBL P06881 9.90 ~0.1 nM 722.9 Da LogP 4.35 TPSA 148.1 1 viol. ✓ Clean Cc1cc(C[C@@H](NC(=O)N2CCC(c3cc4ccc(F)cc4[nH]c3=…
CHEMBL5916342 ChEMBL P06881 9.80 ~0.2 nM 690.9 Da LogP 4.20 TPSA 159.0 1 viol. ✓ Clean Cc1cc(C[C@@H](NC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)C…
CHEMBL6023861 ChEMBL P06881 9.80 ~0.2 nM 731.9 Da LogP 5.69 TPSA 135.2 2 viol. ✓ Clean CCCn1ccnc1C1CCN(C2CCN(C(=O)[C@@H](Cc3cc(C)c4[nH…
CHEMBL3771314 ChEMBL P06881 9.64 ~0.2 nM 641.3 Da LogP 6.66 TPSA 84.6 2 viol. ✓ Clean Cc1cc(C[C@@H](NC(=O)N2CCC(c3cc4ccccc4cc3Cl)CC2)…
CHEMBL3656889 ChEMBL P06881 9.47 ~0.3 nM 543.7 Da LogP 4.47 TPSA 87.2 1 viol. ✓ Clean O=C1NC2(CCCC2)CN(Cc2ccc3cc4c(cc3n2)C[C@]2(C4)C(…
CHEMBL509329 ChEMBL P06881 9.34 ~0.5 nM 3428.0 Da LogP -11.68 TPSA 1331.5 3 viol. ✓ Clean CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=…
CHEMBL524724 ChEMBL P06881 9.28 ~0.5 nM 3369.9 Da LogP -12.05 TPSA 1307.5 3 viol. ✓ Clean CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=…
CHEMBL525039 ChEMBL P06881 9.28 ~0.5 nM 3442.0 Da LogP -11.29 TPSA 1331.5 3 viol. ✓ Clean CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=…
CHEMBL503180 ChEMBL P06881 9.24 ~0.6 nM 3427.0 Da LogP -11.87 TPSA 1338.3 3 viol. ✓ Clean CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=…
CHEMBL525589 ChEMBL P06881 9.24 ~0.6 nM 3427.0 Da LogP -11.87 TPSA 1338.3 3 viol. ✓ Clean CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=…
CHEMBL509603 ChEMBL P06881 9.22 ~0.6 nM 3492.1 Da LogP -10.14 TPSA 1331.5 3 viol. ✓ Clean CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=…
CHEMBL4873687 ChEMBL P10092 9.20 ~0.6 nM 553.7 Da LogP 3.07 TPSA 153.3 1 viol. ✓ Clean CC(C)(C)C(=O)N(CC(=O)Nc1ccc2c(c1)CC1(C2)C(=O)Nc…
CHEMBL500283 ChEMBL P06881 9.19 ~0.6 nM 3311.9 Da LogP -15.84 TPSA 1384.0 3 viol. ✓ Clean CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC…
CHEMBL525810 ChEMBL P06881 9.19 ~0.6 nM 3492.1 Da LogP -10.14 TPSA 1331.5 3 viol. ✓ Clean CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=…
CHEMBL510807 ChEMBL P06881 9.15 ~0.7 nM 3239.8 Da LogP -13.26 TPSA 1300.2 3 viol. ✓ Clean CC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH…
CHEMBL2372187 ChEMBL P06881 9.14 ~0.7 nM 3496.1 Da LogP -10.12 TPSA 1331.5 3 viol. ✓ Clean CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=…
CHEMBL3656892 ChEMBL P06881 9.14 ~0.7 nM 565.7 Da LogP 4.90 TPSA 87.2 1 viol. ✓ Clean O=C1N[C@H](Cc2ccccc2)CN(Cc2ccc3cc4c(cc3n2)C[C@]…
CHEMBL3656894 ChEMBL P06881 9.14 ~0.7 nM 385.5 Da LogP 2.02 TPSA 70.2 ✓ Ro5 ✓ Clean O=C1Nc2ncccc2[C@@]12Cc1cc3ccc(CN4CCNCC4)nc3cc1C2
CHEMBL236593 ChEMBL P06881 9.11 ~0.8 nM 566.5 Da LogP 3.69 TPSA 103.3 1 viol. ✓ Clean O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)…
CHEMBL3656886 ChEMBL P06881 9.11 ~0.8 nM 517.6 Da LogP 3.94 TPSA 87.2 1 viol. ✓ Clean CC1(C)CN(Cc2ccc3cc4c(cc3n2)CC2(C4)C(=O)Nc3ncccc…
CHEMBL2372188 ChEMBL P06881 9.07 ~0.9 nM 3482.1 Da LogP -10.51 TPSA 1331.5 3 viol. ✓ Clean CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=…
CHEMBL4851152 ChEMBL P10092 9.00 ~1.0 nM 551.7 Da LogP 4.34 TPSA 103.4 1 viol. ✓ Clean CC(C)(C)C(=O)N(CC(=O)Nc1ccc2c(c1)CC1(C2)C(=O)Nc…
CHEMBL526728 ChEMBL P06881 8.99 ~1.0 nM 3546.2 Da LogP -10.94 TPSA 1362.8 3 viol. ✓ Clean CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=…
CHEMBL3769439 ChEMBL P06881 8.96 ~1.1 nM 625.6 Da LogP 6.16 TPSA 84.6 2 viol. ✓ Clean Cc1cc(C[C@@H](NC(=O)N2CCC(c3ccc(Cl)cc3Cl)CC2)C(…
CHEMBL4850259 ChEMBL P10092 8.90 ~1.3 nM 525.7 Da LogP 4.10 TPSA 117.4 1 viol. ✓ Clean CC(N)c1ccccc1CN(CC(=O)Nc1ccc2c(c1)CC1(C2)C(=O)N…
CHEMBL2372192 ChEMBL P06881 8.88 ~1.3 nM 3550.2 Da LogP -8.95 TPSA 1331.5 3 viol. ✓ Clean CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=…
CHEMBL526916 ChEMBL P06881 8.81 ~1.5 nM 3518.1 Da LogP -9.62 TPSA 1331.5 3 viol. ✓ Clean CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=…
CHEMBL509374 ChEMBL P06881 8.76 ~1.7 nM 3197.7 Da LogP -13.65 TPSA 1281.4 3 viol. ✓ Clean CC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH…
CHEMBL3656887 ChEMBL P06881 8.74 ~1.8 nM 479.6 Da LogP 3.90 TPSA 70.2 ✓ Ro5 ✓ Clean O=C1C(c2ccc(F)cc2)NCCN1Cc1ccc2cc3c(cc2n1)C[C@@]…
CHEMBL507917 ChEMBL P06881 8.74 ~1.8 nM 3493.1 Da LogP -11.37 TPSA 1354.0 3 viol. ✓ Clean CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=…
CHEMBL524320 ChEMBL P06881 8.71 ~1.9 nM 3460.0 Da LogP -11.38 TPSA 1331.5 3 viol. ✓ Clean CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=…
CHEMBL4877585 ChEMBL P10092 8.70 ~2.0 nM 551.7 Da LogP 4.29 TPSA 94.6 1 viol. ✓ Clean CC(C)(C)C(=O)N(CC(=O)Nc1ccc2c(c1)CC1(C2)C(=O)Nc…
CHEMBL504769 ChEMBL P06881 8.68 ~2.1 nM 3454.1 Da LogP -11.27 TPSA 1345.1 3 viol. ✓ Clean CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=…
CHEMBL4879142 ChEMBL P10092 8.60 ~2.5 nM 525.7 Da LogP 3.58 TPSA 117.4 1 viol. ✓ Clean CC(C)(C)C(=O)N(CC(=O)Nc1ccc2c(c1)CC1(C2)C(=O)Nc…
CHEMBL3656893 ChEMBL P06881 8.59 ~2.6 nM 543.7 Da LogP 4.47 TPSA 87.2 1 viol. ✓ Clean O=C1NC2(CCCC2)CN(Cc2ccc3cc4c(cc3n2)C[C@]2(C4)C(…
CHEMBL3656888 ChEMBL P06881 8.54 ~2.9 nM 434.5 Da LogP 4.02 TPSA 67.3 ✓ Ro5 ✓ Clean O=C1COc2ccccc2N1Cc1ccc2cc3c(cc2n1)C[C@@]1(CNc2n…
CHEMBL3769667 ChEMBL P06881 8.54 ~2.9 nM 653.8 Da LogP 3.33 TPSA 121.9 1 viol. ✓ Clean Cc1cc(C[C@@H](NC(=O)N2CCN(c3ccc(F)cc3S(C)(=O)=O…
CHEMBL4850583 ChEMBL P10092 8.50 ~3.2 nM 562.7 Da LogP 4.33 TPSA 109.2 1 viol. ✓ Clean CC(C)(C)C(=O)N(CC(=O)Nc1ccc2c(c1)CC1(C2)C(=O)Nc…
CHEMBL525571 ChEMBL P06881 8.50 ~3.2 nM 3125.6 Da LogP -17.05 TPSA 1339.2 3 viol. ✓ Clean CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC…
CHEMBL2372194 ChEMBL P06881 8.48 ~3.3 nM 3650.3 Da LogP -6.65 TPSA 1331.5 3 viol. ✓ Clean CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=…
CHEMBL2372193 ChEMBL P06881 8.46 ~3.5 nM 3596.2 Da LogP -7.81 TPSA 1331.5 3 viol. ✓ Clean CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=…
CHEMBL524361 ChEMBL P06881 8.45 ~3.5 nM 3430.0 Da LogP -11.39 TPSA 1340.3 3 viol. ✓ Clean CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=…
CHEMBL505912 ChEMBL P06881 8.42 ~3.8 nM 3416.0 Da LogP -11.82 TPSA 1331.5 3 viol. ✓ Clean CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=…
CHEMBL4857810 ChEMBL P10092 8.40 ~4.0 nM 525.7 Da LogP 3.80 TPSA 103.4 1 viol. ✓ Clean CNCc1ccccc1CN(CC(=O)Nc1ccc2c(c1)CC1(C2)C(=O)Nc2…
CHEMBL4871934 ChEMBL P10092 8.40 ~4.0 nM 497.6 Da LogP 3.67 TPSA 117.4 ✓ Ro5 ✓ Clean CC(C)(C)C(=O)N(CC(=O)Nc1ccc2c(c1)CC1(C2)C(=O)Nc…
CHEMBL2372190 ChEMBL P06881 8.38 ~4.2 nM 3468.0 Da LogP -11.12 TPSA 1331.5 3 viol. ✓ Clean CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=…
CHEMBL3770964 ChEMBL P06881 8.37 ~4.3 nM 626.6 Da LogP 5.10 TPSA 87.8 2 viol. ✓ Clean Cc1cc(C[C@@H](NC(=O)N2CCN(c3ccc(Cl)cc3Cl)CC2)C(…
CHEMBL4852669 ChEMBL P10092 8.30 ~5.0 nM 511.6 Da LogP 3.54 TPSA 117.4 1 viol. ✓ Clean CC(C)(C)C(=O)N(CC(=O)Nc1ccc2c(c1)CC1(C2)C(=O)Nc…
CHEMBL4861626 ChEMBL P10092 8.30 ~5.0 nM 512.6 Da LogP 3.58 TPSA 111.6 1 viol. ✓ Clean CC(C)(C)C(=O)N(CC(=O)Nc1ccc2c(c1)CC1(C2)C(=O)Nc…
CHEMBL4866915 ChEMBL P10092 8.30 ~5.0 nM 522.6 Da LogP 3.96 TPSA 120.1 1 viol. ✓ Clean CC(C)(C)C(=O)N(CC(=O)Nc1ccc2c(c1)CC1(C2)C(=O)Nc…
CHEMBL525416 ChEMBL P06881 8.30 ~5.0 nM 3458.0 Da LogP -12.32 TPSA 1351.8 3 viol. ✓ Clean CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=…
CHEMBL3656890 ChEMBL P06881 8.18 ~6.6 nM 461.6 Da LogP 3.77 TPSA 70.2 ✓ Ro5 ✓ Clean O=C1Nc2ncccc2[C@@]12Cc1cc3ccc(CN4CCNCC4c4ccccc4…
CHEMBL3770165 ChEMBL P06881 8.15 ~7.1 nM 670.3 Da LogP 3.85 TPSA 121.9 1 viol. ✓ Clean Cc1cc(C[C@@H](NC(=O)N2CCN(c3ccc(S(C)(=O)=O)cc3C…
CHEMBL1910937 ChEMBL P06881 8.10 ~7.9 nM 623.3 Da LogP 4.14 TPSA 105.2 1 viol. ✓ Clean CN(C)C(=O)[C@@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1C…
CHEMBL4866548 ChEMBL P10092 8.10 ~7.9 nM 551.7 Da LogP 4.16 TPSA 103.4 1 viol. ✓ Clean CC(C)(C)C(=O)N(CC(=O)Nc1ccc2c(c1)CC1(C2)C(=O)Nc…
CHEMBL4874651 ChEMBL P10092 8.10 ~7.9 nM 581.7 Da LogP 3.92 TPSA 103.9 1 viol. ✓ Clean CC(C)(C)C(=O)N(CC(=O)Nc1ccc2c(c1)CC1(C2)C(=O)Nc…
CHEMBL3769848 ChEMBL P06881 8.05 ~8.9 nM 582.8 Da LogP 3.66 TPSA 111.6 1 viol. ✓ Clean Cc1cc(C[C@@H](NC(=O)N2CCN(c3ccccc3C#N)CC2)C(=O)…
CHEMBL509329 ChEMBL P01256 8.05 ~8.9 nM 3428.0 Da LogP -11.68 TPSA 1331.5 3 viol. ✓ Clean CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=…
CHEMBL3770217 ChEMBL P06881 8.01 ~9.8 nM 591.2 Da LogP 5.50 TPSA 84.6 2 viol. ✓ Clean Cc1cc(C[C@@H](NC(=O)N2CCC(c3ccccc3Cl)CC2)C(=O)N…
CHEMBL501792 ChEMBL P06881 7.95 ~11.2 nM 3471.0 Da LogP -12.04 TPSA 1352.4 3 viol. ✓ Clean CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=…
CHEMBL3769749 ChEMBL P06881 7.92 ~12.0 nM 626.6 Da LogP 5.10 TPSA 87.8 2 viol. ✓ Clean Cc1cc(C[C@@H](NC(=O)N2CCN(c3ccc(Cl)c(Cl)c3)CC2)…
CHEMBL3771271 ChEMBL P06881 7.92 ~12.0 nM 636.6 Da LogP 4.55 TPSA 87.8 1 viol. ✓ Clean Cc1cc(C[C@@H](NC(=O)N2CCN(c3ccccc3Br)CC2)C(=O)N…
CHEMBL3770508 ChEMBL P06881 7.89 ~12.9 nM 635.7 Da LogP 5.61 TPSA 84.6 2 viol. ✓ Clean Cc1cc(C[C@@H](NC(=O)N2CCC(c3ccc(Br)cc3)CC2)C(=O…
CHEMBL3770364 ChEMBL P06881 7.85 ~14.1 nM 606.8 Da LogP 6.00 TPSA 84.6 2 viol. ✓ Clean Cc1cc(C[C@@H](NC(=O)N2CCC(c3ccc4ccccc4c3)CC2)C(…
CHEMBL3771103 ChEMBL P06881 7.82 ~15.1 nM 592.2 Da LogP 4.44 TPSA 87.8 1 viol. ✓ Clean Cc1cc(C[C@@H](NC(=O)N2CCN(c3ccccc3Cl)CC2)C(=O)N…
CHEMBL3770407 ChEMBL P06881 7.80 ~15.8 nM 605.2 Da LogP 5.81 TPSA 84.6 2 viol. ✓ Clean Cc1ccc(C2CCN(C(=O)N[C@H](Cc3cc(C)c4[nH]ncc4c3)C…
CHEMBL3656891 ChEMBL P06881 7.77 ~17.0 nM 557.7 Da LogP 4.86 TPSA 87.2 1 viol. ✓ Clean CC1(Cc2ccccc2)C(=O)NC2(CCCC2)CN1Cc1ccc2cc3c(cc2…
CHEMBL3769428 ChEMBL P06881 7.72 ~19.1 nM 592.2 Da LogP 4.44 TPSA 87.8 1 viol. ✓ Clean Cc1cc(C[C@@H](NC(=O)N2CCN(c3cccc(Cl)c3)CC2)C(=O…
CHEMBL3769533 ChEMBL P06881 7.72 ~19.1 nM 625.6 Da LogP 6.16 TPSA 84.6 2 viol. ✓ Clean Cc1cc(C[C@@H](NC(=O)N2CCC(c3ccc(Cl)c(Cl)c3)CC2)…
CHEMBL504769 ChEMBL P01256 7.69 ~20.4 nM 3454.1 Da LogP -11.27 TPSA 1345.1 3 viol. ✓ Clean CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=…
CHEMBL3770378 ChEMBL P06881 7.66 ~21.9 nM 636.6 Da LogP 4.55 TPSA 87.8 1 viol. ✓ Clean Cc1cc(C[C@@H](NC(=O)N2CCN(c3cccc(Br)c3)CC2)C(=O…
CHEMBL3769892 ChEMBL P06881 7.62 ~24.0 nM 692.7 Da LogP 6.89 TPSA 84.6 2 viol. ✓ Clean Cc1cc(C[C@@H](NC(=O)N2CCC(c3ccc(C(F)(F)F)cc3C(F…
CHEMBL4862324 ChEMBL P10092 7.60 ~25.1 nM 507.6 Da LogP 3.96 TPSA 115.2 1 viol. ✓ Clean CC(C)(C)C(=O)N(CC(=O)Nc1ccc2c(c1)CC1(C2)C(=O)Nc…
CHEMBL2372189 ChEMBL P06881 7.53 ~29.5 nM 3543.1 Da LogP -9.85 TPSA 1347.3 3 viol. Alert CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=…
CHEMBL3769654 ChEMBL P06881 7.48 ~33.1 nM 636.6 Da LogP 4.55 TPSA 87.8 1 viol. ✓ Clean Cc1cc(C[C@@H](NC(=O)N2CCN(c3ccc(Br)cc3)CC2)C(=O…
CHEMBL3770496 ChEMBL P06881 7.47 ~33.9 nM 653.8 Da LogP 3.33 TPSA 121.9 1 viol. ✓ Clean Cc1cc(C[C@@H](NC(=O)N2CCN(c3ccc(S(C)(=O)=O)cc3F…
CHEMBL3656898 ChEMBL P06881 7.46 ~34.7 nM 455.5 Da LogP 2.99 TPSA 94.6 ✓ Ro5 ✓ Clean CN1C(=O)NC(=O)C12Cc1cc3ccc(CN4C(=O)C(C)(C)Nc5cc…
CHEMBL3770694 ChEMBL P06881 7.39 ~40.7 nM 591.2 Da LogP 5.50 TPSA 84.6 2 viol. ✓ Clean Cc1cc(C[C@@H](NC(=O)N2CCC(c3ccc(Cl)cc3)CC2)C(=O…
CHEMBL3656895 ChEMBL P06881 7.37 ~42.7 nM 529.6 Da LogP 4.60 TPSA 87.2 1 viol. ✓ Clean O=C1NC2(CCCC2)CN(Cc2ccc3cc4c(cc3n2)C[C@]2(C4)C(…
CHEMBL3770927 ChEMBL P06881 7.36 ~43.7 nM 629.8 Da LogP 3.97 TPSA 114.1 1 viol. ✓ Clean CCOC(=O)c1ccc(N2CCN(C(=O)N[C@H](Cc3cc(C)c4[nH]n…
CHEMBL3770965 ChEMBL P06881 7.36 ~43.7 nM 557.7 Da LogP 3.79 TPSA 87.8 1 viol. ✓ Clean Cc1cc(C[C@@H](NC(=O)N2CCN(c3ccccc3)CC2)C(=O)N2C…
CHEMBL3770323 ChEMBL P06881 7.34 ~45.7 nM 633.8 Da LogP 5.46 TPSA 87.8 2 viol. ✓ Clean Cc1cc(C[C@@H](NC(=O)N2CCN(c3ccc(-c4ccccc4)cc3)C…
CHEMBL4876643 ChEMBL P10092 7.30 ~50.1 nM 525.6 Da LogP 3.18 TPSA 134.5 1 viol. ✓ Clean CC(C)(C)C(=O)N(CC(=O)Nc1ccc2c(c1)CC1(C2)C(=O)Nc…
CHEMBL3770392 ChEMBL P06881 7.27 ~53.7 nM 614.8 Da LogP 4.64 TPSA 110.9 1 viol. ✓ Clean COC(=O)c1ccccc1C1CCN(C(=O)N[C@H](Cc2cc(C)c3[nH]…
CHEMBL3656896 ChEMBL P06881 7.24 ~57.5 nM 561.7 Da LogP 5.41 TPSA 87.7 2 viol. ✓ Clean CC(C)(C)OC(=O)N1CCN(Cc2ccc3cc4c(cc3n2)C[C@]2(C4…
CHEMBL3770990 ChEMBL P06881 7.11 ~77.6 nM 592.2 Da LogP 4.44 TPSA 87.8 1 viol. ✓ Clean Cc1cc(C[C@@H](NC(=O)N2CCN(c3ccc(Cl)cc3)CC2)C(=O…
CHEMBL2372191 ChEMBL P06881 7.10 ~79.4 nM 3493.0 Da LogP -10.58 TPSA 1338.5 3 viol. Alert CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=…
CHEMBL526890 ChEMBL P06881 7.10 ~79.4 nM 3456.0 Da LogP -10.90 TPSA 1331.5 3 viol. ✓ Clean CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=…

Cross-references

External database identifiers grouped by category.

Structure

  • PDB2FLY
  • PDB2L7S
  • PDB4RWF
  • PDB5V6Y
  • PDB6UUN
  • PDB6UUS
  • PDB6V2E
  • PDB7VV0
  • PDBsum2FLY
  • PDBsum2L7S
  • PDBsum4RWF
  • PDBsum5V6Y
  • PDBsum6UUN
  • PDBsum6UUS
  • PDBsum6V2E
  • PDBsum7VV0
  • AlphaFoldDBP35318
  • EMDBEMD-20883
  • EMDBEMD-20901
  • EMDBEMD-32133
  • SMRP35318

Family & domains

  • InterProIPR051665
  • InterProIPR021116
  • InterProIPR001710
  • PANTHERPTHR23414
  • PANTHERPTHR23414:SF3
  • PfamPF00214
  • PRINTSPR00801

Sequence

  • EMBLD14874
  • EMBLS73906
  • EMBLD43639
  • EMBLCR541995
  • EMBLBT006902
  • EMBLAK312893
  • EMBLDQ143945
  • EMBLCH471064
  • EMBLCH471064
  • EMBLBC015961
  • CCDSCCDS7801.1
  • PIRJC2351
  • RefSeqNP_001115.1

Genome annotation

  • EnsemblENST00000278175.10
  • EnsemblENST00000525063.2
  • EnsemblENST00000528655.5
  • GeneID133
  • KEGGhsa:133
  • MANE-SelectENST00000278175.10
  • UCSCuc001mil.2
  • GenomeRNAi133

Organism databases

  • CTD133
  • DisGeNET133
  • GeneCardsADM
  • HGNCHGNC:259
  • MIM103275

Expression

  • BgeeENSG00000148926
  • ExpressionAtlasP35318

Phylogenomics

  • eggNOGENOG502S4SF
  • GeneTreeENSGT00940000154380
  • HOGENOMCLU_099291_1_0_1
  • InParanoidP35318
  • OMAQSFLYCC
  • OrthoDB8771893at2759
  • PhylomeDBP35318

Proteomic

  • MassIVEP35318
  • PaxDb9606-ENSP00000436607
  • ProteomicsDB55021

Other

  • BioGRID106645
  • FunCoupP35318
  • IntActP35318
  • STRING9606.ENSP00000436607
  • ChEMBLCHEMBL2062356
  • GlyGenP35318
  • iPTMnetP35318
  • PhosphoSitePlusP35318
  • BioMutaADM
  • DMDM461474
  • PeptideAtlasP35318
  • Antibodypedia4233
  • DNASU133
  • AGRHGNC:259
  • ClinPGxPA24580
  • HPAENSG00000148926
  • OpenTargetsENSG00000148926
  • VEuPathDBHostDB:ENSG00000148926
  • PAN-GOP35318
  • PathwayCommonsP35318
  • ReactomeR-HSA-418555
  • ReactomeR-HSA-419812
  • ReactomeR-HSA-9856530
  • SignaLinkP35318
  • SIGNORP35318
  • AgoraENSG00000148926
  • BioGRID-ORCS133
  • ChiTaRSADM
  • EvolutionaryTraceP35318
  • GeneWikiAdrenomedullin
  • PharosP35318
  • PROPR:P35318
  • ProteomesUP000005640
  • RNActP35318
  • GOGO:0005737
  • GOGO:0005576
  • GOGO:0005615
  • GOGO:0034774
  • GOGO:0031700
  • GOGO:0005179
  • GOGO:0005102
  • GOGO:0007189
  • GOGO:1990410
  • GOGO:0060670
  • GOGO:0008283
  • GOGO:0048589
  • GOGO:0002031
  • GOGO:0007507
  • GOGO:0006954
  • GOGO:0043116
  • GOGO:0045906
  • GOGO:0001843
  • GOGO:0045766
  • GOGO:0008284
  • GOGO:0010460
  • GOGO:2000184
  • GOGO:2001214
  • GOGO:0031623
  • GOGO:0003073
  • GOGO:0035809
  • GOGO:0007165
  • GOGO:0097084
  • GOGO:0001570