Overview
Through the degradation of FBXW7, may act indirectly on the expression and downstream signaling of MTOR, JUN and MYC (PubMed:24344117).
Subunit structure
Interacts with FBXW7; promotes FBXW7 degradation (PubMed:24344117). May interact with RAF1 (PubMed:24736947). Interacts with KIF22; recruits KIF22 to mitotic spindle microtubules (PubMed:18485706). Interacts (via C-terminus) with DYNLL1 (PubMed:22965910). Interacts with HMMR (PubMed:22965910). Directly interacts (via DUF1669) with CSNK1A1 and CSNK1A1L (PubMed:29789297, PubMed:31338967)
Publications
- Complete sequencing and characterization of 21,243 full-length human cDNAs.
- The DNA sequence and comparative analysis of human chromosome 20.
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
- Proteome analysis of the human mitotic spindle.
- The spindle protein CHICA mediates localization of the chromokinesin Kid to the mitotic spindle.
- EML3 is a nuclear microtubule-binding protein required for the correct alignment of chromosomes in metaphase.
- Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
- Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
Function
Molecular function, catalytic activity, and Gene Ontology annotations.
Through the degradation of FBXW7, may act indirectly on the expression and downstream signaling of MTOR, JUN and MYC (PubMed:24344117). May play also a role in cell proliferation through activation of the ERK1/ERK2 signaling cascade (PubMed:25646692). May also be important for proper chromosome congression and alignment during mitosis through its interaction with KIF22 (PubMed:18485706)
Biological process
Cellular component
Molecular function
Sequence
585 amino acids
MALLSEGLDEVPAACLSPCGPPNPTELFSESRRLALEELVAGGPEAFAAFLRRERLARFLNPDEVHAILRAAERPGEEGAAAAAAAEDSFGSSHDCSSGTYFPEQSDLEPPLLELGWPAFYQGAYRGATRVETHFQPRGAGEGGPYGCKDALRQQLRSAREVIAVVMDVFTDIDIFRDLQEICRKQGVAVYILLDQALLSQFLDMCMDLKVHPEQEKLMTVRTITGNIYYARSGTKIIGKVHEKFTLIDGIRVATGSYSFTWTDGKLNSSNLVILSGQVVEHFDLEFRILYAQSKPISPKLLSHFQSSNKFDHLTNRKPQSKELTLGNLLRMRLARLSSTPRKADLDPEMPAEGKAERKPHDCESSTVSEEDYFSSHRDELQSRKAIDAATQTEPGEEMPGLSVSEVGTQTSITTACAGTQTAVITRIASSQTTIWSRSTTTQTDMDENILFPRGTQSTEGSPVSKMSVSRSSSLKSSSSVSSQGSVASSTGSPASIRTTDFHNPGYPKYLGTPHLELYLSDSLRNLNKERQFHFAGIRSRLNHMLAMLSRRTLFTENHLGLHSGNFSRVNLLAVRDVALYPSYQ
Cross-references
External database identifiers grouped by category.
Structure
- PDB5E0L
- PDB5E0M
- PDBsum5E0L
- PDBsum5E0M
- AlphaFoldDBQ9H4H8
- SMRQ9H4H8
Family & domains
- Gene3D3.30.870.10
- InterProIPR050944
- InterProIPR012461
- PANTHERPTHR16181
- PANTHERPTHR16181:SF29
- PfamPF07894
- SUPFAMSSF56024
Sequence
- EMBLAK055793
- EMBLAK303860
- EMBLAL023803
- EMBLBC001068
- EMBLBC006553
- EMBLBC053683
- EMBLBC063661
- EMBLBC080188
- CCDSCCDS42872.2
- RefSeqNP_112181.3
Genome annotation
- EnsemblENST00000619850.2
- GeneID81610
- KEGGhsa:81610
- MANE-SelectENST00000619850.2
- UCSCuc061wzh.1
- GenomeRNAi81610
Organism databases
- CTD81610
- DisGeNET81610
- GeneCardsFAM83D
- HGNCHGNC:16122
- MIM618380
Expression
- BgeeENSG00000101447
- ExpressionAtlasQ9H4H8
Phylogenomics
- eggNOGENOG502RC3Z
- GeneTreeENSGT00940000158405
- HOGENOMCLU_040298_0_0_1
- InParanoidQ9H4H8
- OMAHFLDMCM
- OrthoDB9882762at2759
- PhylomeDBQ9H4H8
Proteomic
- jPOSTQ9H4H8
- MassIVEQ9H4H8
- PaxDb9606-ENSP00000481110
- ProteomicsDB80838
- ProteomicsDB80839
Other
- BioGRID123547
- FunCoupQ9H4H8
- IntActQ9H4H8
- MINTQ9H4H8
- STRING9606.ENSP00000481465
- GlyGenQ9H4H8
- iPTMnetQ9H4H8
- PhosphoSitePlusQ9H4H8
- BioMutaFAM83D
- DMDM25452904
- PeptideAtlasQ9H4H8
- PumbaQ9H4H8
- Antibodypedia57303
- DNASU81610
- AGRHGNC:16122
- ClinPGxPA25670
- HPAENSG00000101447
- OpenTargetsENSG00000101447
- VEuPathDBHostDB:ENSG00000101447
- PAN-GOQ9H4H8
- PathwayCommonsQ9H4H8
- ReactomeR-HSA-177929
- SignaLinkQ9H4H8
- SIGNORQ9H4H8
- AgoraENSG00000101447
- BioGRID-ORCS81610
- ChiTaRSFAM83D
- EvolutionaryTraceQ9H4H8
- PharosQ9H4H8
- PROPR:Q9H4H8
- ProteomesUP000005640
- RNActQ9H4H8
- GOGO:0005737
- GOGO:0005829
- GOGO:0045171
- GOGO:0015630
- GOGO:0072686
- GOGO:0097431
- GOGO:0005819
- GOGO:0019894
- GOGO:0008017
- GOGO:0019901
- GOGO:0051301
- GOGO:0016477
- GOGO:0008283
- GOGO:0001837
- GOGO:0051310
- GOGO:1902808
- GOGO:1902480
- GOGO:0070372
- GOGO:0042176
- GOGO:0032006
- GOGO:0007165
- DisProtDP04220
- FunFam3.30.870.10:FF:000004