Overview
Probably involved in signal transduction in the nervous system, via increasing cell surface localization of GRM5/mGluR5 and positively regulating its signaling (PubMed:33711248).
Subunit structure
Interacts with MCHR1 (PubMed:16945926). Interacts with SEMA4C (By similarity). Interacts with DIAPH1 (via FH3 domain) (By similarity). Interacts with GRM5 (By similarity)
Publications
- Molecular cloning and expression of human neurochondrin-1 and -2.
- 10684983
- Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.
- The DNA sequence and biological annotation of human chromosome 1.
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
- Interaction of neurochondrin with the melanin-concentrating hormone receptor 1 interferes with G protein-coupled signal transduction but not agonist-mediated internalization.
- Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
- Initial characterization of the human central proteome.
Function
Molecular function, catalytic activity, and Gene Ontology annotations.
Probably involved in signal transduction in the nervous system, via increasing cell surface localization of GRM5/mGluR5 and positively regulating its signaling (PubMed:33711248). Required for the spatial learning process. Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth (Probable)
Biological process
Cellular component
Sequence
729 amino acids
MSCCDLAAAGQLGKASIMASDCEPALNQAEGRNPTLERYLGALREAKNDSEQFAALLLVTKAVKAGDIDAKTRRRIFDAVGFTFPNRLLTTKEAPDGCPDHVLRALGVALLACFCSDPELAAHPQVLNKIPILSTFLTARGDPDDAARRSMIDDTYQCLTAVAGTPRGPRHLIAGGTVSALCQAYLGHGYGFDQALALLVGLLAAAETQCWKEAEPDLLAVLRGLSEDFQKAEDASKFELCQLLPLFLPPTTVPPECYRDLQAGLARILGSKLSSWQRNPALKLAARLAHACGSDWIPAGSSGSKFLALLVNLACVEVRLALEETGTEVKEDVVTACYALMELGIQECTRCEQSLLKEPQKVQLVSVMKEAIGAVIHYLLQVGSEKQKEPFVFASVRILGAWLAEETSSLRKEVCQLLPFLVRYAKTLYEEAEEANDLSQQVANLAISPTTPGPTWPGDALRLLLPGWCHLTVEDGPREILIKEGAPSLLCKYFLQQWELTSPGHDTSVLPDSVEIGLQTCCHIFLNLVVTAPGLIKRDACFTSLMNTLMTSLPALVQQQGRLLLAANVATLGLLMARLLSTSPALQGTPASRGFFAAAILFLSQSHVARATPGSDQAVLALSPEYEGIWADLQELWFLGMQAFTGCVPLLPWLAPAALRSRWPQELLQLLGSVSPNSVKPEMVAAYQGVLVELARANRLCREAMRLQAGEETASHYRMAALEQCLSEP
Cross-references
External database identifiers grouped by category.
Structure
- AlphaFoldDBQ9UBB6
- SMRQ9UBB6
Family & domains
- InterProIPR016024
- InterProIPR008709
- PANTHERPTHR13109
- PANTHERPTHR13109:SF7
- PfamPF05536
- SUPFAMSSF48371
Sequence
- EMBLAB018739
- EMBLAB018740
- EMBLAB027514
- EMBLAB027514
- EMBLAB011179
- EMBLAC004865
- EMBLCH471059
- EMBLCH471059
- EMBLCH471059
- EMBLBC024592
- CCDSCCDS30672.1
- CCDSCCDS392.1
- RefSeqNP_001014839.1
- RefSeqNP_001014841.1
- RefSeqNP_055099.1
Genome annotation
- EnsemblENST00000356090.8
- EnsemblENST00000373243.7
- EnsemblENST00000373253.7
- GeneID23154
- KEGGhsa:23154
- MANE-SelectENST00000373243.7
- UCSCuc001bza.3
- GenomeRNAi23154
Organism databases
- CTD23154
- DisGeNET23154
- GeneCardsNCDN
- HGNCHGNC:17597
- MIM608458
- MIM619373
Expression
- BgeeENSG00000020129
- ExpressionAtlasQ9UBB6
Phylogenomics
- eggNOGKOG2611
- GeneTreeENSGT00390000013601
- HOGENOMCLU_012443_0_0_1
- InParanoidQ9UBB6
- OMAIVHYKKP
- OrthoDB8186546at2759
- PhylomeDBQ9UBB6
Proteomic
- jPOSTQ9UBB6
- MassIVEQ9UBB6
- PaxDb9606-ENSP00000362340
- ProteomicsDB83925
- ProteomicsDB83926
Other
- BioGRID116768
- FunCoupQ9UBB6
- IntActQ9UBB6
- STRING9606.ENSP00000362340
- GlyGenQ9UBB6
- iPTMnetQ9UBB6
- PhosphoSitePlusQ9UBB6
- SwissPalmQ9UBB6
- BioMutaNCDN
- PeptideAtlasQ9UBB6
- PumbaQ9UBB6
- Antibodypedia17311
- DNASU23154
- AGRHGNC:17597
- ClinPGxPA134963729
- HPAENSG00000020129
- MalaCardsNCDN
- OpenTargetsENSG00000020129
- Orphanet88616
- VEuPathDBHostDB:ENSG00000020129
- PAN-GOQ9UBB6
- PathwayCommonsQ9UBB6
- SignaLinkQ9UBB6
- AgoraENSG00000020129
- BioGRID-ORCS23154
- CD-CODEFB4E32DD
- ChiTaRSNCDN
- GeneWikiNCDN
- PharosQ9UBB6
- PROPR:Q9UBB6
- ProteomesUP000005640
- RNActQ9UBB6
- GOGO:0005829
- GOGO:0030425
- GOGO:0010008
- GOGO:0098978
- GOGO:0016020
- GOGO:0043025
- GOGO:0043204
- GOGO:0098794
- GOGO:0045453
- GOGO:0031175
- GOGO:0048168
- GOGO:0099149