Protein profile

VK055_0008

GDSL-like Lipase/Acylhydrolase family protein

Genome: KpATCC43816

Gene: AIK78639.1 Structure source: AlphaFold + ColabFold UniProt A0A9Q6EUN7
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Amino acids 780
Annotations 1
Features 5
PDB binders 0
Druggability 0.299

Overview

Basic information about this protein and its source genome.

Accession
VK055_0008
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK78639.1
Status
annotated
Amino acids
780
Structure source
AlphaFold + ColabFold
GO
GO:0016788 Catalysis of the hydrolysis of any ester bond.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
85.87

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.299
Structure A0A9Q6EUN7
Pocket Pocket 7
P2Rank 0.119
Structure A0A9Q6EUN7
Pocket Pocket 1
ColabFold model
FPocket 0.681 · Pocket 1
P2Rank 0.072 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 1 / 4744 genomes with a hit
Normalized 0

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0016788 Catalysis of the hydrolysis of any ester bond.

Sequence Features

Domain/signature hits from InterPro and related databases.

5 records
Show feature table
Start End DB Term Name
572 758 Pfam PF13472 GDSL-like Lipase/Acylhydrolase family
572 758 InterPro IPR013830 SGNH hydrolase-type esterase domain
562 777 Gene3D G3DSA:3.40.50.1110 SGNH hydrolase
562 777 InterPro IPR036514 SGNH hydrolase superfamily
560 774 SUPERFAMILY SSF52266 SGNH hydrolase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A9Q6EUN7
AlphaFold — — full sequence — Viewing
ColabFold VK055_0008
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
7 0.299

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.95 0.04