Protein profile

VK055_0009

resolvase, N terminal domain protein

Genome: KpATCC43816

Gene: AIK78640.1 Structure source: AlphaFold + ColabFold UniProt A0A483LMV2
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Amino acids 192
Annotations 3
Features 23
PDB binders 0
Druggability 0.088

Overview

Basic information about this protein and its source genome.

Accession
VK055_0009
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK78640.1
Status
annotated
Amino acids
192
Structure source
AlphaFold + ColabFold
GO
GO:0006310 Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0000150 Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
28.283
Localization
Cytoplasmic
ColabFold pLDDT
81.83

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.088
Structure A0A483LMV2
Pocket Pocket 4
P2Rank 0.112
Structure A0A483LMV2
Pocket Pocket 1
ColabFold model
FPocket 0.091 · Pocket 5
P2Rank 0.119 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 50 / 4744 genomes with a hit
Normalized 0.011

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0006310 Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
  • GO:0000150 Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

23 records
Show feature table
Start End DB Term Name
55 67 ProSitePatterns PS00398 Site-specific recombinases signature 2.
55 67 InterPro IPR006118 Recombinase, conserved site
1 134 ProSiteProfiles PS51736 Resolvase/invertase-type recombinase catalytic domain profile.
1 134 InterPro IPR006119 Resolvase, N-terminal catalytic domain
1 135 SUPERFAMILY SSF53041 Resolvase-like
1 135 InterPro IPR036162 Resolvase-like, N-terminal catalytic domain superfamily
138 182 SUPERFAMILY SSF46689 Homeodomain-like
138 182 InterPro IPR009057 Homeobox-like domain superfamily
138 179 CDD cd00569 HTH_Hin_like
138 184 Gene3D G3DSA:1.10.10.60 -
3 135 Pfam PF00239 Resolvase, N terminal domain
3 135 InterPro IPR006119 Resolvase, N-terminal catalytic domain
3 141 PANTHER PTHR30461 DNA-INVERTASE FROM LAMBDOID PROPHAGE
2 136 Gene3D G3DSA:3.40.50.1390 -
2 136 InterPro IPR036162 Resolvase-like, N-terminal catalytic domain superfamily
1 125 FunFam G3DSA:3.40.50.1390:FF:000001 DNA recombinase
2 126 CDD cd03768 SR_ResInv
2 136 SMART SM00857 resolvase_6
2 136 InterPro IPR006119 Resolvase, N-terminal catalytic domain
138 181 Pfam PF02796 Helix-turn-helix domain of resolvase
138 181 InterPro IPR006120 Resolvase, HTH domain
5 13 ProSitePatterns PS00397 Site-specific recombinases active site.
5 13 InterPro IPR006118 Recombinase, conserved site

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A483LMV2
AlphaFold — — full sequence — Viewing
ColabFold VK055_0009
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.12 0.105