Protein profile

VK055_0015

HD domain protein

Genome: KpATCC43816

Gene: AIK78646.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GS86
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Amino acids 235
Annotations 0
Features 9
PDB binders 0
Druggability 0.152

Overview

Basic information about this protein and its source genome.

Accession
VK055_0015
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK78646.1
Status
annotated
Amino acids
235
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
91.51

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.152
Structure A0A0H3GS86
Pocket Pocket 14
P2Rank 0.87
Structure A0A0H3GS86
Pocket Pocket 1
ColabFold model
FPocket 0.124 · Pocket 15
P2Rank 0.908 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 69 / 4744 genomes with a hit
Normalized 0.015

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
1 235 Gene3D G3DSA:1.10.3210.50 -
5 214 PANTHER PTHR33594 SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G03035)-RELATED
25 136 CDD cd00077 HDc
25 136 InterPro IPR003607 HD/PDEase domain
22 141 SMART SM00471 hd_13
22 141 InterPro IPR003607 HD/PDEase domain
28 130 Pfam PF01966 HD domain
28 130 InterPro IPR006674 HD domain
1 215 SUPERFAMILY SSF109604 HD-domain/PDEase-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GS86
AlphaFold — — full sequence — Viewing
ColabFold VK055_0015
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 15.77 0.761