Protein profile

VK055_0023

positive DNA-binding transcriptional regulator of capsular polysaccharide synthesis, activates its own expression

Genome: KpATCC43816

Gene: AIK78654.1 rcsA Structure source: AlphaFold + ColabFold UniProt A0A0H3GQD4
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Amino acids 204
Annotations 2
Features 22
PDB binders 0
Druggability 0.263

Overview

Basic information about this protein and its source genome.

Accession
VK055_0023
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK78654.1 rcsA
Status
annotated
Amino acids
204
Structure source
AlphaFold + ColabFold
GO
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
67.157
DEG E-value
2.93e-99
Localization
Unknown
ColabFold pLDDT
91.77

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.263
Structure A0A0H3GQD4
Pocket Pocket 4
P2Rank 0.016
Structure A0A0H3GQD4
Pocket Pocket 1
ColabFold model
FPocket 0.545 · Pocket 5
P2Rank 0.326 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 74 / 4744 genomes with a hit
Normalized 0.016

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

22 records
Show feature table
Start End DB Term Name
119 185 SUPERFAMILY SSF46894 C-terminal effector domain of the bipartite response regulators
119 185 InterPro IPR016032 Signal transduction response regulator, C-terminal effector
98 193 Gene3D G3DSA:1.10.10.10 -
98 193 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
149 176 ProSitePatterns PS00622 LuxR-type HTH domain signature.
149 176 InterPro IPR000792 Transcription regulator LuxR, C-terminal
128 193 ProSiteProfiles PS50043 LuxR-type HTH domain profile.
128 193 InterPro IPR000792 Transcription regulator LuxR, C-terminal
134 188 Pfam PF00196 Bacterial regulatory proteins, luxR family
134 188 InterPro IPR000792 Transcription regulator LuxR, C-terminal
135 191 CDD cd06170 LuxR_C_like
135 191 InterPro IPR000792 Transcription regulator LuxR, C-terminal
149 165 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature
149 165 InterPro IPR000792 Transcription regulator LuxR, C-terminal
135 149 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature
135 149 InterPro IPR000792 Transcription regulator LuxR, C-terminal
165 177 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature
165 177 InterPro IPR000792 Transcription regulator LuxR, C-terminal
1 204 Hamap MF_00982 Transcriptional regulatory protein RcsA [rcsA].
1 204 InterPro IPR030866 Transcriptional regulatory protein RcsA
132 189 SMART SM00421 luxrmega5
132 189 InterPro IPR000792 Transcription regulator LuxR, C-terminal

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GQD4
AlphaFold — — full sequence — Viewing
ColabFold VK055_0023
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.263

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 0.83 0.003