Protein profile

VK055_0061

copper homeostasis protein

Genome: KpATCC43816

Gene: AIK78689.1 cutC Structure source: AlphaFold + ColabFold UniProt A0A0H3GQ70
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Amino acids 247
Annotations 2
Features 11
PDB binders 0
Druggability 0.329

Overview

Basic information about this protein and its source genome.

Accession
VK055_0061
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK78689.1 cutC
Status
annotated
Amino acids
247
Structure source
AlphaFold + ColabFold
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005507 Binding to a copper (Cu) ion.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
50.307
Human E-value
5.62e-48
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
69.835
DEG E-value
7.170000000000001e-124
Localization
Cytoplasmic
ColabFold pLDDT
97.05

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.329
Structure A0A0H3GQ70
Pocket Pocket 1
P2Rank 0.702
Structure A0A0H3GQ70
Pocket Pocket 1
ColabFold model
FPocket 0.314 · Pocket 1
P2Rank 0.729 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 111 / 4744 genomes with a hit
Normalized 0.023

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0005507 Binding to a copper (Cu) ion.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
3 244 SUPERFAMILY SSF110395 CutC-like
3 244 InterPro IPR036822 CutC-like domain superfamily
2 202 Hamap MF_00795 PF03932 family protein CutC [cutC].
2 202 InterPro IPR005627 CutC-like
2 246 PANTHER PTHR12598 COPPER HOMEOSTASIS PROTEIN CUTC
2 246 InterPro IPR005627 CutC-like
1 247 Gene3D G3DSA:3.20.20.380 Copper homeostasis (CutC) domain
1 247 InterPro IPR036822 CutC-like domain superfamily
1 245 FunFam G3DSA:3.20.20.380:FF:000001 Copper homeostasis protein CutC
3 200 Pfam PF03932 CutC family
3 200 InterPro IPR005627 CutC-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GQ70
AlphaFold — — full sequence — Viewing
ColabFold VK055_0061
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.329

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 11.58 0.617