Protein profile

VK055_0069

DNA-binding regulatory, YebC/PmpR family protein

Genome: KpATCC43816

Gene: AIK78697.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GUU7
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Amino acids 246
Annotations 3
Features 18
PDB binders 0
Druggability 0.9

Overview

Basic information about this protein and its source genome.

Accession
VK055_0069
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK78697.1
Status
annotated
Amino acids
246
Structure source
AlphaFold + ColabFold
GO
GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
31.174
Human E-value
2.73e-32
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
94.715
DEG E-value
1.55e-175
Localization
Cytoplasmic
ColabFold pLDDT
92.02

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.9
Structure A0A0H3GUU7
Pocket Pocket 1
P2Rank 0.727
Structure A0A0H3GUU7
Pocket Pocket 1
ColabFold model
FPocket 0.588 · Pocket 14
P2Rank 0.67 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 637 / 4744 genomes with a hit
Normalized 0.134

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

18 records
Show feature table
Start End DB Term Name
1 235 PANTHER PTHR12532 UNCHARACTERIZED
1 235 InterPro IPR002876 Transcriptional regulator TACO1-like
130 204 FunFam G3DSA:3.30.70.980:FF:000002 Probable transcriptional regulatory protein YebC
1 236 NCBIfam TIGR01033 YebC/PmpR family DNA-binding transcriptional regulator
1 236 InterPro IPR002876 Transcriptional regulator TACO1-like
1 81 FunFam G3DSA:1.10.10.200:FF:000001 Probable transcriptional regulatory protein YebC
5 235 Pfam PF01709 Transcriptional regulator
5 235 InterPro IPR002876 Transcriptional regulator TACO1-like
3 244 SUPERFAMILY SSF75625 YebC-like
3 244 InterPro IPR029072 YebC-like
3 238 Hamap MF_00693 Probable transcriptional regulatory protein YebC [yebC].
3 238 InterPro IPR002876 Transcriptional regulator TACO1-like
130 204 Gene3D G3DSA:3.30.70.980 -
130 204 InterPro IPR026564 Transcriptional regulator TACO1-like, domain 3
1 81 Gene3D G3DSA:1.10.10.200 -
1 81 InterPro IPR017856 Integrase-like, N-terminal
85 235 Gene3D G3DSA:3.30.70.980 -
85 235 InterPro IPR026564 Transcriptional regulator TACO1-like, domain 3

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GUU7
AlphaFold — — full sequence — Viewing
ColabFold VK055_0069
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.9

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 9.91 0.533
2 4.75 0.209
3 3.48 0.127