Protein profile

VK055_0108

small protein involved in the acid stress response

Genome: KpATCC43816

Gene: mgrB AIK78736.1 Structure source: AlphaFold + ColabFold UniProt A0A0E4AX29
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Amino acids 47
Annotations 2
Features 11
PDB binders 0
Druggability 0.474

Overview

Basic information about this protein and its source genome.

Accession
VK055_0108
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
mgrB AIK78736.1
Status
annotated
Amino acids
47
Structure source
AlphaFold + ColabFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0070298 Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction via a phosphorelay signal transduction system.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
72.34
DEG E-value
1.95e-15
Localization
CytoplasmicMembrane
ColabFold pLDDT
80.1

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.474
Structure A0A0E4AX29
Pocket Pocket 1
P2Rank
Structure A0A0E4AX29
Pocket No pockets
ColabFold model
FPocket 0.67 · Pocket 3
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 29 / 4744 genomes with a hit
Normalized 0.006

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0070298 Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction via a phosphorelay signal transduction system.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
1 16 ProSiteProfiles PS51257 Prokaryotic membrane lipoprotein lipid attachment site profile.
1 47 Hamap MF_01596 PhoP/PhoQ regulator MgrB [mgrB].
1 47 InterPro IPR020907 PhoP/PhoQ regulator MgrB
29 47 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
7 20 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 6 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
21 28 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 28 Phobius SIGNAL_PEPTIDE Signal peptide region
7 24 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
19 47 Pfam PF13998 MgrB protein
19 47 InterPro IPR020907 PhoP/PhoQ regulator MgrB

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0E4AX29
AlphaFold — — full sequence — Viewing
ColabFold VK055_0108
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.474