Protein profile

VK055_0121

NUDIX domain protein

Genome: KpATCC43816

Gene: AIK78749.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GQ11
Export view
Amino acids 192
Annotations 6
Features 15
PDB binders 0
Druggability 0.455

Overview

Basic information about this protein and its source genome.

Accession
VK055_0121
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK78749.1
Status
annotated
Amino acids
192
Structure source
AlphaFold + ColabFold
EC
3.6.1.-
GO
GO:0010945 Catalysis of the reaction: an acyl-coenzyme A or its derivatives + H2O = adenosine 3',5'-bisphosphate + an acyl-4'-phosphopantetheine + 2 H+. This reaction can also use coenzyme A as a substrate. GO:0009132 The chemical reactions and pathways involving a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar. GO:0030145 Binding to a manganese ion (Mn). GO:0016818 Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. GO:0000287 Binding to a magnesium (Mg) ion.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
41.837
Human E-value
1.06e-12
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
90.06

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.455
Structure A0A0H3GQ11
Pocket Pocket 7
P2Rank 0.854
Structure A0A0H3GQ11
Pocket Pocket 1
ColabFold model
FPocket 0.19 · Pocket 7
P2Rank 0.805 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 106 / 4744 genomes with a hit
Normalized 0.022

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 5 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

5
  • GO:0010945 Catalysis of the reaction: an acyl-coenzyme A or its derivatives + H2O = adenosine 3',5'-bisphosphate + an acyl-4'-phosphopantetheine + 2 H+. This reaction can also use coenzyme A as a substrate.
  • GO:0009132 The chemical reactions and pathways involving a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar.
  • GO:0030145 Binding to a manganese ion (Mn).
  • GO:0016818 Catalysis of the hydrolysis of any acid anhydride which contains phosphorus.
  • GO:0000287 Binding to a magnesium (Mg) ion.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records
Show feature table
Start End DB Term Name
30 184 CDD cd03426 CoAse
30 184 InterPro IPR045121 Coenzyme A pyrophosphatase
1 190 Hamap MF_01592 Uncharacterized Nudix hydrolase NudL [nudL].
1 190 InterPro IPR023735 Uncharacterised nudix hydrolase NudL
29 160 ProSiteProfiles PS51462 Nudix hydrolase domain profile.
29 160 InterPro IPR000086 NUDIX hydrolase domain
47 67 ProSitePatterns PS01293 Nudix CoA signature.
47 67 InterPro IPR000059 NUDIX hydrolase, NudL, conserved site
8 181 SUPERFAMILY SSF55811 Nudix
8 181 InterPro IPR015797 NUDIX hydrolase-like domain superfamily
10 187 Gene3D G3DSA:3.90.79.10 Nucleoside Triphosphate Pyrophosphohydrolase
30 143 Pfam PF00293 NUDIX domain
30 143 InterPro IPR000086 NUDIX hydrolase domain
7 185 PANTHER PTHR12992 NUDIX HYDROLASE
7 185 InterPro IPR045121 Coenzyme A pyrophosphatase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GQ11
AlphaFold — — full sequence — Viewing
ColabFold VK055_0121
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
7 0.455

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 13.72 0.697
2 4.33 0.18