Protein profile

VK055_0127

outer membrane lipo, Slp family protein

Genome: KpATCC43816

Gene: AIK78755.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GZY8
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Amino acids 193
Annotations 1
Features 17
PDB binders 0
Druggability 0.368

Overview

Basic information about this protein and its source genome.

Accession
VK055_0127
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK78755.1
Status
annotated
Amino acids
193
Structure source
AlphaFold + ColabFold
GO
GO:0019867 The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
41.04
DEG E-value
2.69e-37
Localization
OuterMembrane
ColabFold pLDDT
81.61

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.368
Structure A0A0H3GZY8
Pocket Pocket 4
P2Rank
Structure A0A0H3GZY8
Pocket No pockets
ColabFold model
FPocket 0.227 · Pocket 2
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 97 / 4744 genomes with a hit
Normalized 0.02

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0019867 The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
1 25 Phobius SIGNAL_PEPTIDE Signal peptide region
1 23 ProSiteProfiles PS51257 Prokaryotic membrane lipoprotein lipid attachment site profile.
1 29 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
10 20 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 25 SignalP_EUK SignalP-noTM SignalP-noTM
10 187 NCBIfam TIGR00752 Slp family lipoprotein
10 187 InterPro IPR004658 Outer membrane lipoprotein Slp
1 19 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
1 9 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
11 188 PANTHER PTHR37530 OUTER MEMBRANE PROTEIN SLP
11 188 InterPro IPR004658 Outer membrane lipoprotein Slp
26 193 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
21 25 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
5 190 PIRSF PIRSF004982 SlP
5 190 InterPro IPR004658 Outer membrane lipoprotein Slp
20 172 Pfam PF03843 Outer membrane lipoprotein Slp family
20 172 InterPro IPR004658 Outer membrane lipoprotein Slp

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GZY8
AlphaFold — — full sequence — Viewing
ColabFold VK055_0127
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.263
8 0.033
5 0.004
6 0.002