Protein profile

VK055_0134

fumarylacetoacetate hydrolase domain-containing protein 1

Genome: KpATCC43816

Gene: AIK78762.1 fahHD1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GVA6
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Amino acids 219
Annotations 3
Features 8
PDB binders 3
Druggability 0.456

Overview

Basic information about this protein and its source genome.

Accession
VK055_0134
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK78762.1 fahHD1
Status
annotated
Amino acids
219
Structure source
AlphaFold + ColabFold
GO
GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0018773 Catalysis of the reaction: acetylpyruvate + H2O = acetate + H+ + pyruvate. GO:0046872 Binding to a metal ion.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
46.465
Human E-value
1.95e-62
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
86.758
DEG E-value
1.53e-145
Localization
Cytoplasmic
ColabFold pLDDT
97.07

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.456
Structure A0A0H3GVA6
Pocket Pocket 2
P2Rank 0.8
Structure A0A0H3GVA6
Pocket Pocket 1
ColabFold model
FPocket 0.285 · Pocket 4
P2Rank 0.786 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 115 / 4744 genomes with a hit
Normalized 0.024

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
  • GO:0018773 Catalysis of the reaction: acetylpyruvate + H2O = acetate + H+ + pyruvate.
  • GO:0046872 Binding to a metal ion.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
11 212 PANTHER PTHR11820 ACYLPYRUVASE
11 213 SUPERFAMILY SSF56529 FAH
11 213 InterPro IPR036663 Fumarylacetoacetase-like, C-terminal domain superfamily
1 219 Gene3D G3DSA:3.90.850.10 -
1 219 InterPro IPR036663 Fumarylacetoacetase-like, C-terminal domain superfamily
1 219 FunFam G3DSA:3.90.850.10:FF:000007 Fumarylacetoacetate hydrolase family protein
18 213 Pfam PF01557 Fumarylacetoacetate (FAA) hydrolase family
18 213 InterPro IPR011234 Fumarylacetoacetase-like, C-terminal

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GVA6
AlphaFold — — full sequence — Viewing
ColabFold VK055_0134
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.456

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 14.4 0.721
2 0.82 0.003

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

18 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
OXL
6FOG
Q6P587-1 88.0 Da LogP -3.51 TPSA 80.3 ✓ Ro5 ✓ Clean C(=O)(C(=O)[O-])[O-]
PYR
6J5X
Q8NLC0 88.1 Da LogP -0.34 TPSA 54.4 ✓ Ro5 ✓ Clean CC(=O)C(=O)O
TAR
3V77
D2YW46 150.1 Da LogP -2.12 TPSA 115.1 ✓ Ro5 ✓ Clean [C@H]([C@@H](C(=O)O)O)(C(=O)O)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.