Protein profile

VK055_0152

transglutaminase-like superfamily protein

Genome: KpATCC43816

Gene: AIK78780.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GRQ7
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Amino acids 271
Annotations 0
Features 11
PDB binders 0
Druggability 0.575

Overview

Basic information about this protein and its source genome.

Accession
VK055_0152
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK78780.1
Status
annotated
Amino acids
271
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
90.33

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.575
Structure A0A0H3GRQ7
Pocket Pocket 6
P2Rank 0.32
Structure A0A0H3GRQ7
Pocket Pocket 1
ColabFold model
FPocket 0.465 · Pocket 15
P2Rank 0.348 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 30 / 4744 genomes with a hit
Normalized 0.006

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
78 250 Gene3D G3DSA:3.10.620.30 -
116 217 Pfam PF01841 Transglutaminase-like superfamily
116 217 InterPro IPR002931 Transglutaminase-like
51 255 SUPERFAMILY SSF54001 Cysteine proteinases
51 255 InterPro IPR038765 Papain-like cysteine peptidase superfamily
5 80 Pfam PF08379 Bacterial transglutaminase-like N-terminal region
5 80 InterPro IPR013589 Bacterial transglutaminase-like, N-terminal
1 245 PANTHER PTHR33490 BLR5614 PROTEIN-RELATED
265 271 Coils Coil Coil
158 220 SMART SM00460 TG_5
158 220 InterPro IPR002931 Transglutaminase-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GRQ7
AlphaFold — — full sequence — Viewing
ColabFold VK055_0152
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
6 0.575
1 0.026
8 0.019
10 0.002

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 7.31 0.32
2 4.8 0.175
3 3.04 0.081
4 1.59 0.021