Protein profile

VK055_0186

valine-glycine repeat protein G

Genome: KpATCC43816

Gene: AIK78814.1 vgrG2 Structure source: AlphaFold + ColabFold UniProt A0A483P0L3
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Amino acids 899
Annotations 0
Features 25
PDB binders 0
Druggability 0.629

Overview

Basic information about this protein and its source genome.

Accession
VK055_0186
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK78814.1 vgrG2
Status
annotated
Amino acids
899
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
45.554
DEG E-value
0.0
Localization
Unknown
ColabFold pLDDT
86.04

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.629
Structure A0A483P0L3
Pocket Pocket 2
P2Rank 0.415
Structure A0A483P0L3
Pocket Pocket 1
ColabFold model
FPocket 0.899 · Pocket 71
P2Rank 0.229 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 24 / 4744 genomes with a hit
Normalized 0.005

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

25 records
Show feature table
Start End DB Term Name
851 899 MobiDBLite mobidb-lite consensus disorder prediction
382 472 SUPERFAMILY SSF69255 gp5 N-terminal domain-like
612 759 Pfam PF10106 Uncharacterized protein conserved in bacteria (DUF2345)
612 759 InterPro IPR018769 Type VI secretion system spike protein VgrG2, domain of unknown function DUF2345
35 355 Pfam PF05954 Phage tail baseplate hub (GPD)
200 383 SUPERFAMILY SSF69279 Phage tail proteins
27 516 NCBIfam TIGR01646 type VI secretion system tip protein VgrG
27 516 InterPro IPR006533 Type VI secretion system, RhsGE-associated Vgr protein
863 882 MobiDBLite mobidb-lite consensus disorder prediction
404 472 Pfam PF04717 Type VI secretion system/phage-baseplate injector OB domain
404 472 InterPro IPR006531 Gp5/Type VI secretion system Vgr protein, OB-fold domain
17 517 NCBIfam TIGR03361 type VI secretion system tip protein TssI/VgrG N-terminal domain
17 517 InterPro IPR017847 Type VI secretion system, RhsGE-associated Vgr family subset
28 331 Gene3D G3DSA:2.30.110.50 -
376 476 Gene3D G3DSA:2.40.50.230 -
376 476 InterPro IPR037026 Vgr protein, OB-fold domain superfamily
24 282 PANTHER PTHR32305 -
895 899 Coils Coil Coil
883 899 MobiDBLite mobidb-lite consensus disorder prediction
15 198 SUPERFAMILY SSF69279 Phage tail proteins
491 592 Pfam PF13296 Putative type VI secretion system Rhs element Vgr
491 592 InterPro IPR028244 Putative type VI secretion system, Rhs element associated Vgr domain
107 203 Gene3D G3DSA:3.55.50.10 -
236 309 Gene3D G3DSA:4.10.220.110 -
572 599 Coils Coil Coil

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A483P0L3
AlphaFold — — full sequence — Viewing
ColabFold VK055_0186
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
73 0.142
75 0.021
68 0.009
1 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 9.04 0.415
2 5.11 0.193
3 4.82 0.176
4 4.37 0.151
5 4.23 0.142