Protein profile

VK055_0228

NMT1-like family protein

Genome: KpATCC43816

Gene: AIK78856.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GZJ8
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Amino acids 418
Annotations 1
Features 17
PDB binders 0
Druggability 0.532

Overview

Basic information about this protein and its source genome.

Accession
VK055_0228
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK78856.1
Status
annotated
Amino acids
418
Structure source
AlphaFold + ColabFold
GO
GO:0012505 A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
92.51

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.532
Structure A0A0H3GZJ8
Pocket Pocket 5
P2Rank 0.063
Structure A0A0H3GZJ8
Pocket Pocket 1
ColabFold model
FPocket 0.201 · Pocket 5
P2Rank 0.033 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 64 / 4744 genomes with a hit
Normalized 0.013

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0012505 A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
26 34 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
17 377 PANTHER PTHR30024 ALIPHATIC SULFONATES-BINDING PROTEIN-RELATED
12 25 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
12 34 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
45 397 Gene3D G3DSA:3.40.190.10 -
130 408 Gene3D G3DSA:3.40.190.10 -
35 418 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
42 281 SUPERFAMILY SSF53850 Periplasmic binding protein-like II
1 31 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
1 34 Phobius SIGNAL_PEPTIDE Signal peptide region
1 11 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 34 ProSiteProfiles PS51318 Twin arginine translocation (Tat) signal profile.
1 34 InterPro IPR006311 Twin-arginine translocation pathway, signal sequence
38 289 Pfam PF13379 NMT1-like family
1 31 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
45 270 CDD cd13553 PBP2_NrtA_CpmA_like
45 270 InterPro IPR044527 Nitrate/bicarbonate ABC transporter substrate-binding domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GZJ8
AlphaFold — — full sequence — Viewing
ColabFold VK055_0228
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.019
11 0.004
2 0.001
7 0.001

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.64 0.063
2 1.57 0.02
3 1.42 0.015
4 1.26 0.011