Protein profile

VK055_0380

CRISPR type I-E/ECOLI-associated protein CasA/Cse1

Genome: KpATCC43816

Gene: casA AIK79006.1 Structure source: AlphaFold + ColabFold UniProt A0A0C7KCD5
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Amino acids 507
Annotations 0
Features 4
PDB binders 0
Druggability 0.359

Overview

Basic information about this protein and its source genome.

Accession
VK055_0380
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
casA AIK79006.1
Status
annotated
Amino acids
507
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
93.35

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.359
Structure A0A0C7KCD5
Pocket Pocket 1
P2Rank 0.372
Structure A0A0C7KCD5
Pocket Pocket 1
ColabFold model
FPocket 0.783 · Pocket 3
P2Rank 0.588 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 2 / 4744 genomes with a hit
Normalized 0

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

4 records
Show feature table
Start End DB Term Name
6 474 Pfam PF09481 CRISPR-associated protein Cse1 (CRISPR_cse1)
6 474 InterPro IPR013381 CRISPR-associated protein Cse1
6 496 NCBIfam TIGR02547 type I-E CRISPR-associated protein Cse1/CasA
6 496 InterPro IPR013381 CRISPR-associated protein Cse1

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0C7KCD5
AlphaFold — — full sequence — Viewing
ColabFold VK055_0380
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.359
12 0.321
7 0.004
8 0.001

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 8.23 0.372
2 6.46 0.274
3 3.86 0.122
4 3.13 0.085
5 2.75 0.068