Protein profile

VK055_0386

CRISPR-associated endoribonuclease Cas2, subtypeI-E/ECOLI

Genome: KpATCC43816

Gene: cas2 AIK79012.1 Structure source: ColabFold
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Amino acids 79
Annotations 0
Features 4
PDB binders 0
Druggability 0.702

Overview

Basic information about this protein and its source genome.

Accession
VK055_0386
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
cas2 AIK79012.1
Status
annotated
Amino acids
79
Structure source
ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
91.82

Selected Druggability evidence

ColabFold / curated model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.702
Structure CB_VK055_0386
Pocket Pocket 2
P2Rank 0.3
Structure CB_VK055_0386
Pocket Pocket 1
ColabFold model
FPocket 0.702 · Pocket 2
P2Rank 0.3 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 12 / 4744 genomes with a hit
Normalized 0.003

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

4 records
Show feature table
Start End DB Term Name
1 71 NCBIfam TIGR01873 type I-E CRISPR-associated endoribonuclease Cas2e
1 71 InterPro IPR010152 CRISPR-associated protein Cas2 subtype
1 60 Gene3D G3DSA:3.30.70.240 -
1 71 Pfam PF09707 CRISPR-associated protein (Cas_Cas2CT1978)

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
ColabFold VK055_0386
ColabFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.702

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 7.24 0.377