Protein profile

VK055_0390

gluconate 2-dehydrogenase subunit 3

Genome: KpATCC43816

Gene: AIK79016.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GUP8
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Amino acids 250
Annotations 0
Features 11
PDB binders 0
Druggability 0.222

Overview

Basic information about this protein and its source genome.

Accession
VK055_0390
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK79016.1
Status
annotated
Amino acids
250
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
83.48

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.222
Structure A0A0H3GUP8
Pocket Pocket 7
P2Rank 0.028
Structure A0A0H3GUP8
Pocket Pocket 1
ColabFold model
FPocket 0.77 · Pocket 2
P2Rank 0.02 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 38 / 4744 genomes with a hit
Normalized 0.008

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
69 223 Pfam PF13618 Gluconate 2-dehydrogenase subunit 3
69 223 InterPro IPR027056 Gluconate 2-dehydrogenase subunit 3
1 42 ProSiteProfiles PS51318 Twin arginine translocation (Tat) signal profile.
1 42 InterPro IPR006311 Twin-arginine translocation pathway, signal sequence
45 250 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
27 44 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
19 26 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 44 Phobius SIGNAL_PEPTIDE Signal peptide region
1 18 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
13 35 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 44 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GUP8
AlphaFold — — full sequence — Viewing
ColabFold VK055_0390
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
7 0.222

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.31 0.014