Protein profile

VK055_0439

efflux transporter, RND family, MFP subunit

Genome: KpATCC43816

Gene: AIK79065.1 Structure source: AlphaFold + ColabFold UniProt A0A5B1TDX7
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Amino acids 389
Annotations 5
Features 14
PDB binders 0
Druggability 0.99

Overview

Basic information about this protein and its source genome.

Accession
VK055_0439
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK79065.1
Status
annotated
Amino acids
389
Structure source
AlphaFold + ColabFold
GO
GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:1990281 A protein complex that is capable of efflux transmembrane transporter activity. GO:0015562 Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
26.133
Localization
CytoplasmicMembrane
ColabFold pLDDT
84.41

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.99
Structure A0A5B1TDX7
Pocket Pocket 3
P2Rank 0.001
Structure A0A5B1TDX7
Pocket Pocket 1
ColabFold model
FPocket 0.275 · Pocket 19
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 22 / 4744 genomes with a hit
Normalized 0.005

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:1990281 A protein complex that is capable of efflux transmembrane transporter activity.
  • GO:0015562 Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
42 389 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
80 222 Gene3D G3DSA:2.40.50.100 -
21 40 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
82 286 Pfam PF16576 Barrel-sandwich domain of CusB or HlyD membrane-fusion
82 286 InterPro IPR032317 RND efflux pump, membrane fusion protein, barrel-sandwich domain
56 378 NCBIfam TIGR01730 efflux RND transporter periplasmic adaptor subunit
56 378 InterPro IPR006143 RND efflux pump, membrane fusion protein
1 20 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
21 41 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
74 285 Gene3D G3DSA:2.40.30.170 -
115 188 Gene3D G3DSA:1.10.287.470 Helix hairpin bin
28 382 PANTHER PTHR30469 MULTIDRUG RESISTANCE PROTEIN MDTA
71 300 SUPERFAMILY SSF111369 HlyD-like secretion proteins
287 379 Gene3D G3DSA:2.40.420.20 -

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A5B1TDX7
AlphaFold — — full sequence — Viewing
ColabFold VK055_0439
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.99
12 0.318