Protein profile

VK055_0442

integrase core domain protein

Genome: KpATCC43816

Gene: AIK79068.1 Structure source: ColabFold
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Amino acids 288
Annotations 2
Features 15
PDB binders 0
Druggability 0.536

Overview

Basic information about this protein and its source genome.

Accession
VK055_0442
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK79068.1
Status
annotated
Amino acids
288
Structure source
ColabFold
GO
GO:0015074 The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome. GO:0003676 Binding to a nucleic acid.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
35.772
Localization
Unknown
ColabFold pLDDT
90.83

Selected Druggability evidence

ColabFold / curated model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.536
Structure CB_VK055_0442
Pocket Pocket 22
P2Rank 0.604
Structure CB_VK055_0442
Pocket Pocket 1
ColabFold model
FPocket 0.536 · Pocket 22
P2Rank 0.604 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 12 / 4744 genomes with a hit
Normalized 0.003

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0015074 The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.
  • GO:0003676 Binding to a nucleic acid.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records
Show feature table
Start End DB Term Name
124 287 ProSiteProfiles PS50994 Integrase catalytic domain profile.
124 287 InterPro IPR001584 Integrase, catalytic core
124 275 Gene3D G3DSA:3.30.420.10 -
124 275 InterPro IPR036397 Ribonuclease H superfamily
52 101 Pfam PF13276 HTH-like domain
52 101 InterPro IPR025948 HTH-like domain
7 286 PANTHER PTHR46889 TRANSPOSASE INSF FOR INSERTION SEQUENCE IS3B-RELATED
120 282 SUPERFAMILY SSF53098 Ribonuclease H-like
120 282 InterPro IPR012337 Ribonuclease H-like superfamily
2 283 NCBIfam NF033516 IS3 family transposase
124 283 FunFam G3DSA:3.30.420.10:FF:000030 IS3, transposase orfB
231 287 Pfam PF13333 Integrase core domain
231 287 InterPro IPR001584 Integrase, catalytic core
127 224 Pfam PF00665 Integrase core domain
127 224 InterPro IPR001584 Integrase, catalytic core

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
ColabFold VK055_0442
ColabFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.01
20 0.001
4 0.0
21 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 13.48 0.604
2 6.96 0.301
3 2.97 0.077
4 2.76 0.068
5 2.35 0.05