Protein profile

VK055_0443

alpha-ketoglutarate permease

Genome: KpATCC43816

Gene: AIK79069.1 csbX Structure source: AlphaFold + ColabFold UniProt A0A0C7KKJ9
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Amino acids 411
Annotations 4
Features 51
PDB binders 0
Druggability 0.933

Overview

Basic information about this protein and its source genome.

Accession
VK055_0443
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK79069.1 csbX
Status
annotated
Amino acids
411
Structure source
AlphaFold + ColabFold
GO
GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
90.8

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.933
Structure A0A0C7KKJ9
Pocket Pocket 1
P2Rank 0.981
Structure A0A0C7KKJ9
Pocket Pocket 1
ColabFold model
FPocket 0.705 · Pocket 4
P2Rank 0.985 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 1 / 4744 genomes with a hit
Normalized 0

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

51 records
Show feature table
Start End DB Term Name
104 126 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
312 336 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
97 107 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
369 373 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
221 243 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
253 275 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
127 137 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
337 347 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
7 197 Gene3D G3DSA:1.20.1250.20 MFS general substrate transporter like domains
7 197 InterPro IPR036259 MFS transporter superfamily
395 411 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
48 69 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
230 248 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
275 285 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
311 333 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
348 368 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
307 311 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
12 36 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
8 400 SUPERFAMILY SSF103473 MFS general substrate transporter
8 400 InterPro IPR036259 MFS transporter superfamily
76 94 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
346 368 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
40 391 PANTHER PTHR43124 PURINE EFFLUX PUMP PBUE
189 229 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
76 96 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
138 157 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
374 394 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
12 34 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
286 306 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
13 395 CDD cd17337 MFS_CsbX
254 274 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
227 397 Pfam PF07690 Major Facilitator Superfamily
227 397 InterPro IPR011701 Major facilitator superfamily
284 306 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
37 47 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
4 395 NCBIfam TIGR00897 RbtT/DalT/CsbX family MFS transporter
4 395 InterPro IPR004748 Polyol permease-like
49 71 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
169 188 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
70 75 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
166 188 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
372 394 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
249 253 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
213 406 Gene3D G3DSA:1.20.1250.20 MFS general substrate transporter like domains
213 406 InterPro IPR036259 MFS transporter superfamily
158 168 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
139 161 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
108 126 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 11 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
10 399 ProSiteProfiles PS50850 Major facilitator superfamily (MFS) profile.
10 399 InterPro IPR020846 Major facilitator superfamily domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0C7KKJ9
AlphaFold — — full sequence — Viewing
ColabFold VK055_0443
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.933

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 35.81 0.954
2 4.64 0.202
3 1.67 0.028
4 1.37 0.016
5 1.17 0.01