Protein profile

VK055_0454

binding-protein-dependent transport system innermembrane component family protein

Genome: KpATCC43816

Gene: AIK79080.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GP90
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Amino acids 315
Annotations 2
Features 32
PDB binders 0
Druggability 0.88

Overview

Basic information about this protein and its source genome.

Accession
VK055_0454
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK79080.1
Status
annotated
Amino acids
315
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
36.752
Localization
CytoplasmicMembrane
ColabFold pLDDT
88.19

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.88
Structure A0A0H3GP90
Pocket Pocket 2
P2Rank 0.435
Structure A0A0H3GP90
Pocket Pocket 1
ColabFold model
FPocket 0.971 · Pocket 1
P2Rank 0.435 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 40 / 4744 genomes with a hit
Normalized 0.008

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

32 records
Show feature table
Start End DB Term Name
171 190 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
299 315 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
221 243 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
40 62 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
62 102 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
40 61 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
279 298 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
170 187 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
138 160 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
103 128 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
103 125 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
25 310 PANTHER PTHR43386 OLIGOPEPTIDE TRANSPORT SYSTEM PERMEASE PROTEIN APPC
26 78 Pfam PF12911 N-terminal TM domain of oligopeptide transport permease C
26 78 InterPro IPR025966 Oligopeptide transport permease C-like, N-terminal domain
102 302 CDD cd06261 TM_PBP2
102 302 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
1 39 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
101 299 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
101 299 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
96 295 SUPERFAMILY SSF161098 MetI-like
96 295 InterPro IPR035906 MetI-like superfamily
160 170 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
119 311 Pfam PF00528 Binding-protein-dependent transport system inner membrane component
119 311 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
279 298 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
140 159 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
93 307 Gene3D G3DSA:1.10.3720.10 -
93 307 InterPro IPR035906 MetI-like superfamily
243 278 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
129 139 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
221 242 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
191 220 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GP90
AlphaFold — — full sequence — Viewing
ColabFold VK055_0454
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.88
14 0.766
4 0.711
20 0.242

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 8.47 0.452
2 4.58 0.197
3 1.71 0.03
4 1.68 0.029
5 1.57 0.024