Protein profile

VK055_0510

electron transport complex, RnfABCDGE type, G subunit

Genome: KpATCC43816

Gene: AIK79133.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GP60
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Amino acids 206
Annotations 5
Features 19
PDB binders 0
Druggability 0.296

Overview

Basic information about this protein and its source genome.

Accession
VK055_0510
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK79133.1
Status
annotated
Amino acids
206
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0010181 Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0022900 A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0009055 A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
80.583
DEG E-value
2.65e-127
Localization
Periplasmic
ColabFold pLDDT
92.45

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.296
Structure A0A0H3GP60
Pocket Pocket 3
P2Rank 0.02
Structure A0A0H3GP60
Pocket Pocket 1
ColabFold model
FPocket 0.214 · Pocket 2
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 130 / 4744 genomes with a hit
Normalized 0.027

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0010181 Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
  • GO:0022900 A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0009055 A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways.

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records
Show feature table
Start End DB Term Name
99 191 SMART SM00900 FMN_bind_2
99 191 InterPro IPR007329 FMN-binding
1 24 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
1 202 PIRSF PIRSF006091 E_trnsport_RnfG
1 202 InterPro IPR010209 Ion-translocating oxidoreductase complex, subunit RnfG/RsxG
18 24 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 204 PANTHER PTHR36118 ION-TRANSLOCATING OXIDOREDUCTASE COMPLEX SUBUNIT G
1 204 InterPro IPR010209 Ion-translocating oxidoreductase complex, subunit RnfG/RsxG
1 24 Phobius SIGNAL_PEPTIDE Signal peptide region
2 193 Hamap MF_00479 Ion-translocating oxidoreductase complex subunit G [rsxG].
2 193 InterPro IPR010209 Ion-translocating oxidoreductase complex, subunit RnfG/RsxG
99 187 Pfam PF04205 FMN-binding domain
99 187 InterPro IPR007329 FMN-binding
9 192 NCBIfam TIGR01947 RnfABCDGE type electron transport complex subunit G
9 192 InterPro IPR010209 Ion-translocating oxidoreductase complex, subunit RnfG/RsxG
1 24 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
9 17 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 8 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
25 206 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GP60
AlphaFold — — full sequence — Viewing
ColabFold VK055_0510
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.099
5 0.05
1 0.032
2 0.005

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.59 0.02