Protein profile

VK055_0633

acetyltransferase family protein

Genome: KpATCC43816

Gene: AIK79256.1 Structure source: AlphaFold + ColabFold UniProt A0A231UM45
Export view
Amino acids 317
Annotations 4
Features 19
PDB binders 0
Druggability 0.628

Overview

Basic information about this protein and its source genome.

Accession
VK055_0633
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK79256.1
Status
annotated
Amino acids
317
Structure source
AlphaFold + ColabFold
GO
GO:0016747 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0008080 Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
30.172
Human E-value
5.47e-06
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
88.4

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.628
Structure A0A231UM45
Pocket Pocket 1
P2Rank 0.943
Structure A0A231UM45
Pocket Pocket 1
ColabFold model
FPocket 0.984 · Pocket 1
P2Rank 0.947 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 24 / 4744 genomes with a hit
Normalized 0.005

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0016747 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0008080 Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule.

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records
Show feature table
Start End DB Term Name
5 143 SUPERFAMILY SSF46785 Winged helix DNA-binding domain
5 143 InterPro IPR036390 Winged helix DNA-binding domain superfamily
163 303 PANTHER PTHR13947 GNAT FAMILY N-ACETYLTRANSFERASE
3 138 ProSiteProfiles PS50995 MarR-type HTH domain profile.
3 138 InterPro IPR000835 MarR-type HTH domain
209 273 CDD cd04301 NAT_SF
162 302 SUPERFAMILY SSF55729 Acyl-CoA N-acyltransferases (Nat)
162 302 InterPro IPR016181 Acyl-CoA N-acyltransferase
26 126 SMART SM00347 marrlong4
26 126 InterPro IPR000835 MarR-type HTH domain
164 300 Gene3D G3DSA:3.40.630.30 -
165 306 ProSiteProfiles PS51186 Gcn5-related N-acetyltransferase (GNAT) domain profile.
165 306 InterPro IPR000182 GNAT domain
2 147 Gene3D G3DSA:1.10.10.10 -
2 147 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
195 290 Pfam PF00583 Acetyltransferase (GNAT) family
195 290 InterPro IPR000182 GNAT domain
34 90 Pfam PF12802 MarR family
34 90 InterPro IPR000835 MarR-type HTH domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A231UM45
AlphaFold — — full sequence — Viewing
ColabFold VK055_0633
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.628
2 0.576
5 0.001
8 0.001

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 38.92 0.943
2 3.54 0.105
3 1.39 0.014
4 0.86 0.003
5 0.65 0.001