Protein profile

VK055_0714

efflux transporter, RND family, MFP subunit

Genome: KpATCC43816

Gene: AIK79337.1 Structure source: AlphaFold + ColabFold UniProt A0A0C7KMP9
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Amino acids 347
Annotations 1
Features 17
PDB binders 0
Druggability 0.452

Overview

Basic information about this protein and its source genome.

Accession
VK055_0714
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK79337.1
Status
annotated
Amino acids
347
Structure source
AlphaFold + ColabFold
GO
GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
42.105
DEG E-value
6.38e-63
Localization
CytoplasmicMembrane
ColabFold pLDDT
91.33

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.452
Structure A0A0C7KMP9
Pocket Pocket 1
P2Rank
Structure A0A0C7KMP9
Pocket No pockets
ColabFold model
FPocket 0.339 · Pocket 10
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 7 / 4744 genomes with a hit
Normalized 0.001

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
50 81 Gene3D G3DSA:2.40.50.100 -
6 344 PANTHER PTHR30386 MEMBRANE FUSION SUBUNIT OF EMRAB-TOLC MULTIDRUG EFFLUX PUMP
229 346 Gene3D G3DSA:2.40.30.170 -
50 94 Pfam PF13533 Biotin-lipoyl like
50 94 InterPro IPR039562 Membrane fusion protein, biotin-lipoyl like domain
9 31 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 9 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
82 183 Gene3D G3DSA:1.10.287.470 Helix hairpin bin
49 174 SUPERFAMILY SSF111369 HlyD-like secretion proteins
22 26 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 11 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
156 291 Pfam PF16576 Barrel-sandwich domain of CusB or HlyD membrane-fusion
156 291 InterPro IPR032317 RND efflux pump, membrane fusion protein, barrel-sandwich domain
166 268 SUPERFAMILY SSF111369 HlyD-like secretion proteins
1 26 Phobius SIGNAL_PEPTIDE Signal peptide region
10 21 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
27 347 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0C7KMP9
AlphaFold — — full sequence — Viewing
ColabFold VK055_0714
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.452
2 0.007
9 0.0
17 0.0