Protein profile

VK055_0787

coenzyme A transferase family protein

Genome: KpATCC43816

Gene: AIK79410.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GXH0
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Amino acids 530
Annotations 4
Features 13
PDB binders 0
Druggability 0.585

Overview

Basic information about this protein and its source genome.

Accession
VK055_0787
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK79410.1
Status
annotated
Amino acids
530
Structure source
AlphaFold + ColabFold
EC
2.8.3.8
GO
GO:0008410 Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor). GO:0046952 The chemical reactions and pathways resulting in the breakdown of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Ketone bodies can be used as an energy source as an alternative to glucose. Utilization of ketone bodies in peripheral tissues involves conversion of acetoacetate to acetoacetyl-CoA, which is then converted to two molecules of acetyl-CoA. GO:0008775 Catalysis of the reaction: acyl-CoA + acetate = a fatty acid anion + acetyl-CoA.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
24.138
Human E-value
1.95e-08
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
36.68
Localization
Cytoplasmic
ColabFold pLDDT
95.68

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.585
Structure A0A0H3GXH0
Pocket Pocket 2
P2Rank 0.934
Structure A0A0H3GXH0
Pocket Pocket 1
ColabFold model
FPocket 0.782 · Pocket 1
P2Rank 0.944 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 45 / 4744 genomes with a hit
Normalized 0.009

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 3 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

3
  • GO:0008410 Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor).
  • GO:0046952 The chemical reactions and pathways resulting in the breakdown of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Ketone bodies can be used as an energy source as an alternative to glucose. Utilization of ketone bodies in peripheral tissues involves conversion of acetoacetate to acetoacetyl-CoA, which is then converted to two molecules of acetyl-CoA.
  • GO:0008775 Catalysis of the reaction: acyl-CoA + acetate = a fatty acid anion + acetyl-CoA.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
1 269 Gene3D G3DSA:3.40.1080.10 -
2 520 PANTHER PTHR43293 ACETATE COA-TRANSFERASE YDIF
8 242 Pfam PF01144 Coenzyme A transferase
8 242 InterPro IPR004165 Coenzyme A transferase family I
276 524 Gene3D G3DSA:3.40.1080.10 -
5 243 SMART SM00882 CoA_trans_3
5 243 InterPro IPR004165 Coenzyme A transferase family I
2 247 SUPERFAMILY SSF100950 NagB/RpiA/CoA transferase-like
2 247 InterPro IPR037171 NagB/RpiA transferase-like
1 525 PIRSF PIRSF000858 SCOT-t
1 525 InterPro IPR014388 3-oxoacid CoA-transferase
277 519 SUPERFAMILY SSF100950 NagB/RpiA/CoA transferase-like
277 519 InterPro IPR037171 NagB/RpiA transferase-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GXH0
AlphaFold — — full sequence — Viewing
ColabFold VK055_0787
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.324
5 0.135
3 0.021
12 0.003

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 35.71 0.934
2 6.4 0.269
3 1.71 0.025
4 1.49 0.017
5 1.41 0.015