Protein profile

VK055_0856

putative acyl-CoA N-acyltransferase

Genome: KpATCC43816

Gene: AIK79480.1 Structure source: Experimental + ColabFold UniProt A6T8Z3
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Amino acids 160
Annotations 1
Features 9
PDB binders 0
Druggability 0.557

Overview

Basic information about this protein and its source genome.

Accession
VK055_0856
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK79480.1
Status
annotated
Amino acids
160
Structure source
Experimental + ColabFold
GO
GO:0016747 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
32.979
Localization
Unknown
ColabFold pLDDT
92.27

Selected Druggability evidence

PDB experimental structure

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.557
Structure 3LOD
Pocket Pocket 1
P2Rank 0.499
Structure 3LOD
Pocket Pocket 1
ColabFold model
FPocket 0.442 · Pocket 2
P2Rank 0.403 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 30 / 4744 genomes with a hit
Normalized 0.006

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0016747 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
2 152 ProSiteProfiles PS51186 Gcn5-related N-acetyltransferase (GNAT) domain profile.
2 152 InterPro IPR000182 GNAT domain
23 151 PANTHER PTHR43877 -
1 160 Gene3D G3DSA:3.40.630.30 -
1 152 SUPERFAMILY SSF55729 Acyl-CoA N-acyltransferases (Nat)
1 152 InterPro IPR016181 Acyl-CoA N-acyltransferase
56 112 CDD cd04301 NAT_SF
39 129 Pfam PF00583 Acetyltransferase (GNAT) family
39 129 InterPro IPR000182 GNAT domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 3LOD
X-ray 20.00 Å - —
PDBe RCSB PDBj File
Viewing
ColabFold VK055_0856
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.557

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 9.31 0.499