Protein profile

VK055_0889

recF/RecN/SMC N terminal domain protein

Genome: KpATCC43816

Gene: AIK79512.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GSL0
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Amino acids 362
Annotations 4
Features 11
PDB binders 0
Druggability 0.331

Overview

Basic information about this protein and its source genome.

Accession
VK055_0889
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK79512.1
Status
annotated
Amino acids
362
Structure source
AlphaFold + ColabFold
GO
GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887 Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0000731 Synthesis of DNA that proceeds from the broken 3' single-strand DNA end and uses the homologous intact duplex as the template. GO:0006302 The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
94.07

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.331
Structure A0A0H3GSL0
Pocket Pocket 4
P2Rank 0.411
Structure A0A0H3GSL0
Pocket Pocket 1
ColabFold model
FPocket 0.42 · Pocket 3
P2Rank 0.344 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 31 / 4744 genomes with a hit
Normalized 0.007

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0016887 Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
  • GO:0000731 Synthesis of DNA that proceeds from the broken 3' single-strand DNA end and uses the homologous intact duplex as the template.
  • GO:0006302 The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
206 361 Gene3D G3DSA:3.40.50.300 -
206 361 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
23 336 Pfam PF13304 AAA domain, putative AbiEii toxin, Type IV TA system
23 336 InterPro IPR003959 ATPase, AAA-type, core
1 96 Gene3D G3DSA:3.40.50.300 -
1 96 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
1 54 PANTHER PTHR32182 DNA REPLICATION AND REPAIR PROTEIN RECF
1 359 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases
1 359 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
1 362 PIRSF PIRSF029347 RecF
1 362 InterPro IPR014555 RecF-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GSL0
AlphaFold — — full sequence — Viewing
ColabFold VK055_0889
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.01
12 0.004
15 0.001
3 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 8.94 0.411
2 3.81 0.119
3 2.35 0.05