Protein profile

VK055_0905

bacterial regulatory, luxR family protein

Genome: KpATCC43816

Gene: AIK79527.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GT35
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Amino acids 209
Annotations 2
Features 20
PDB binders 0
Druggability 0.674

Overview

Basic information about this protein and its source genome.

Accession
VK055_0905
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK79527.1
Status
annotated
Amino acids
209
Structure source
AlphaFold + ColabFold
GO
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
83.47

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.674
Structure A0A0H3GT35
Pocket Pocket 4
P2Rank 0.399
Structure A0A0H3GT35
Pocket Pocket 1
ColabFold model
FPocket 0.87 · Pocket 5
P2Rank 0.131 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 4 / 4744 genomes with a hit
Normalized 0.001

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

20 records
Show feature table
Start End DB Term Name
157 184 ProSitePatterns PS00622 LuxR-type HTH domain signature.
157 184 InterPro IPR000792 Transcription regulator LuxR, C-terminal
135 196 SUPERFAMILY SSF46894 C-terminal effector domain of the bipartite response regulators
135 196 InterPro IPR016032 Signal transduction response regulator, C-terminal effector
102 201 Gene3D G3DSA:1.10.10.10 -
102 201 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
142 196 Pfam PF00196 Bacterial regulatory proteins, luxR family
142 196 InterPro IPR000792 Transcription regulator LuxR, C-terminal
140 197 SMART SM00421 luxrmega5
140 197 InterPro IPR000792 Transcription regulator LuxR, C-terminal
143 196 CDD cd06170 LuxR_C_like
143 196 InterPro IPR000792 Transcription regulator LuxR, C-terminal
143 157 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature
143 157 InterPro IPR000792 Transcription regulator LuxR, C-terminal
173 185 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature
173 185 InterPro IPR000792 Transcription regulator LuxR, C-terminal
157 173 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature
157 173 InterPro IPR000792 Transcription regulator LuxR, C-terminal
136 201 ProSiteProfiles PS50043 LuxR-type HTH domain profile.
136 201 InterPro IPR000792 Transcription regulator LuxR, C-terminal

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GT35
AlphaFold — — full sequence — Viewing
ColabFold VK055_0905
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
11 0.093
9 0.005
14 0.003
2 0.001

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 8.73 0.399
2 4.42 0.153
3 4.18 0.14
4 1.25 0.011