Protein profile

VK055_0919

hypothetical protein

Genome: KpATCC43816

Gene: AIK79542.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GT26

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Amino acids 89

Annotations 0

Features 9

PDB binders 0

Druggability 0.325

Overview

Basic information about this protein and its source genome.

Accession: VK055_0919
Assembly: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene: AIK79542.1
Status: annotated
Amino acids: 89
Structure source: AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Human identity (%): 0.0
Gut microbiome off-target: hit
Essential (DEG): Y
DEG identity (%): 64.835
DEG E-value: 2.3800000000000002e-29
Localization: Periplasmic
ColabFold pLDDT: 77.7

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.325

Structure A0A0H3GT26

Pocket Pocket 2

P2Rank

Structure A0A0H3GT26

Pocket No pockets

ColabFold model

FPocket 0.035 · Pocket 2

Core conservation Accessory gene

Roary core

CoreCruncher accessory

Gut microbiome 84 / 4744 genomes with a hit

Normalized 0.018

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records

Show feature table

Start	End	DB	Term	Name
15	20	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.
21	89	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1	20	Phobius	SIGNAL_PEPTIDE	Signal peptide region
25	78	Pfam	PF06649	Protein of unknown function (DUF1161)
25	78	InterPro	IPR010595	Protein of unknown function DUF1161
1	20	SignalP_GRAM_POSITIVE	SignalP-TM	SignalP-TM
1	20	SignalP_GRAM_NEGATIVE	SignalP-noTM	SignalP-noTM
1	2	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.
3	14	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold AF_A0A0H3GT26	AlphaFold	—	—	full sequence	—	Viewing
ColabFold VK055_0919	ColabFold	—	—	full sequence	—	Loaded

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
2				0.325
3				0.002
1				0.0

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
2				0.035
1				0.0