Protein profile

VK055_0945

malonate decarboxylase holo-[acyl-carrier-protein] synthase

Genome: KpATCC43816

Gene: AIK79568.1 mdcG Structure source: AlphaFold + ColabFold UniProt A0A0H3GX10
Export view
Amino acids 205
Annotations 2
Features 5
PDB binders 0
Druggability 0.54

Overview

Basic information about this protein and its source genome.

Accession
VK055_0945
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK79568.1 mdcG
Status
annotated
Amino acids
205
Structure source
AlphaFold + ColabFold
EC
2.7.7.66
GO
GO:0016779 Catalysis of the transfer of a nucleotidyl group from one compound (donor) to another (acceptor).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
94.54

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.54
Structure A0A0H3GX10
Pocket Pocket 1
P2Rank 0.399
Structure A0A0H3GX10
Pocket Pocket 1
ColabFold model
FPocket 0.087 · Pocket 8
P2Rank 0.448 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 49 / 4744 genomes with a hit
Normalized 0.01

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 1 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

1
  • GO:0016779 Catalysis of the transfer of a nucleotidyl group from one compound (donor) to another (acceptor).

Sequence Features

Domain/signature hits from InterPro and related databases.

5 records
Show feature table
Start End DB Term Name
6 199 NCBIfam TIGR03135 malonate decarboxylase holo-[acyl-carrier-protein] synthase
6 199 InterPro IPR017557 Phosphoribosyl-dephospho-CoA transferase
6 199 Pfam PF10620 Phosphoribosyl-dephospho-CoA transferase MdcG
4 205 Hamap MF_00650 Phosphoribosyl-dephospho-CoA transferase [mdcG].
4 205 InterPro IPR017557 Phosphoribosyl-dephospho-CoA transferase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GX10
AlphaFold — — full sequence — Viewing
ColabFold VK055_0945
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.54
2 0.327
3 0.029
6 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 8.73 0.399