Protein profile

VK055_0964

3-oxoadipate CoA-transferase subunit B

Genome: KpATCC43816

Gene: AIK79587.1 catJ Structure source: AlphaFold + ColabFold UniProt A0A0H3GMV0
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Amino acids 218
Annotations 1
Features 13
PDB binders 0
Druggability 0.362

Overview

Basic information about this protein and its source genome.

Accession
VK055_0964
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK79587.1 catJ
Status
annotated
Amino acids
218
Structure source
AlphaFold + ColabFold
GO
GO:0008410 Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor).

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
44.66
Human E-value
7.509999999999998e-54
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
71.351
DEG E-value
5.36e-97
Localization
Cytoplasmic
ColabFold pLDDT
94.14

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.362
Structure A0A0H3GMV0
Pocket Pocket 1
P2Rank 0.636
Structure A0A0H3GMV0
Pocket Pocket 1
ColabFold model
FPocket 0.292 · Pocket 5
P2Rank 0.465 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 83 / 4744 genomes with a hit
Normalized 0.017

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0008410 Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor).

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
5 212 SUPERFAMILY SSF100950 NagB/RpiA/CoA transferase-like
5 212 InterPro IPR037171 NagB/RpiA transferase-like
45 53 ProSitePatterns PS01274 Coenzyme A transferases signature 2.
45 53 InterPro IPR004164 Coenzyme A transferase active site
7 201 Pfam PF01144 Coenzyme A transferase
7 201 InterPro IPR004165 Coenzyme A transferase family I
1 214 Gene3D G3DSA:3.40.1080.10 -
7 204 SMART SM00882 CoA_trans_3
7 204 InterPro IPR004165 Coenzyme A transferase family I
5 211 PANTHER PTHR13707 KETOACID-COENZYME A TRANSFERASE
5 211 InterPro IPR004165 Coenzyme A transferase family I
5 210 NCBIfam TIGR02428 3-oxoacid CoA-transferase subunit B
5 210 InterPro IPR012791 3-oxoacid CoA-transferase, subunit B

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GMV0
AlphaFold — — full sequence — Viewing
ColabFold VK055_0964
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.362
2 0.162
17 0.027
15 0.001

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 14.37 0.636