Protein profile

VK055_1105

type VI secretion system protein

Genome: KpATCC43816

Gene: impC2 AIK79728.1 Structure source: ColabFold
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Amino acids 333
Annotations 0
Features 8
PDB binders 0
Druggability 0.426

Overview

Basic information about this protein and its source genome.

Accession
VK055_1105
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
impC2 AIK79728.1
Status
annotated
Amino acids
333
Structure source
ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
45.697
DEG E-value
4.78e-103
Localization
Cytoplasmic
ColabFold pLDDT
90.23

Selected Druggability evidence

ColabFold / curated model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.426
Structure CB_VK055_1105
Pocket Pocket 21
P2Rank 0.358
Structure CB_VK055_1105
Pocket Pocket 1
ColabFold model
FPocket 0.426 · Pocket 21
P2Rank 0.358 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 67 / 4744 genomes with a hit
Normalized 0.014

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
1 332 PANTHER PTHR35565 CYTOPLASMIC PROTEIN-RELATED
1 332 InterPro IPR010269 Type VI secretion system TssC-like
218 328 Pfam PF18945 EvpB/VC_A0108, tail sheath gpW/gp25-like domain
218 328 InterPro IPR044032 TssC1, C-terminal
1 329 NCBIfam TIGR03355 type VI secretion system contractile sheath large subunit
1 329 InterPro IPR010269 Type VI secretion system TssC-like
1 208 Pfam PF05943 EvpB/VC_A0108, tail sheath N-terminal domain
1 208 InterPro IPR044031 TssC1, N-terminal

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
ColabFold VK055_1105
ColabFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
21 0.426
13 0.0
20 0.0
25 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 7.98 0.358
2 4.95 0.184
3 2.77 0.068
4 1.53 0.018
5 1.45 0.016