Protein profile

VK055_1175

TPR repeat family protein

Genome: KpATCC43816

Gene: AIK79798.1 Structure source: AlphaFold + ColabFold UniProt A0A085DE04
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Amino acids 389
Annotations 5
Features 28
PDB binders 0
Druggability 0.171

Overview

Basic information about this protein and its source genome.

Accession
VK055_1175
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK79798.1
Status
annotated
Amino acids
389
Structure source
AlphaFold + ColabFold
GO
GO:0005515 Binding to a protein. GO:0008653 The chemical reactions and pathways involving lipopolysaccharides, a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide. GO:0009898 The leaflet of the plasma membrane that faces the cytoplasm, including any protein embedded in, attached to, or peripherally associated with it. GO:0005506 Binding to an iron (Fe) ion. GO:0046890 Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
87.368
DEG E-value
0.0
Localization
Cytoplasmic
ColabFold pLDDT
92.09

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.171
Structure A0A085DE04
Pocket Pocket 4
P2Rank 0.307
Structure A0A085DE04
Pocket Pocket 1
ColabFold model
FPocket 0.47 · Pocket 5
P2Rank 0.309 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 116 / 4744 genomes with a hit
Normalized 0.024

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0005515 Binding to a protein.
  • GO:0008653 The chemical reactions and pathways involving lipopolysaccharides, a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide.
  • GO:0009898 The leaflet of the plasma membrane that faces the cytoplasm, including any protein embedded in, attached to, or peripherally associated with it.
  • GO:0005506 Binding to an iron (Fe) ion.
  • GO:0046890 Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids.

Sequence Features

Domain/signature hits from InterPro and related databases.

28 records
Show feature table
Start End DB Term Name
17 389 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
191 245 Pfam PF14559 Tetratricopeptide repeat
12 16 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
214 247 ProSiteProfiles PS50005 TPR repeat profile.
214 247 InterPro IPR019734 Tetratricopeptide repeat
4 387 Hamap MF_00994 Lipopolysaccharide assembly protein B [lapB].
4 387 InterPro IPR030865 Lipopolysaccharide assembly protein B
355 382 Pfam PF18073 Rubredoxin metal binding domain
355 382 InterPro IPR041166 LapB, rubredoxin metal binding domain
20 353 Gene3D G3DSA:1.25.40.10 Tetratricopeptide repeat domain
20 353 InterPro IPR011990 Tetratricopeptide-like helical domain superfamily
109 279 SUPERFAMILY SSF48452 TPR-like
109 279 InterPro IPR011990 Tetratricopeptide-like helical domain superfamily
39 183 FunFam G3DSA:1.25.40.10:FF:000033 Lipopolysaccharide assembly protein B
1 16 SignalP_EUK SignalP-noTM SignalP-noTM
109 319 PANTHER PTHR45586 TPR REPEAT-CONTAINING PROTEIN PA4667
1 3 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
282 315 SMART SM00028 tpr_5
282 315 InterPro IPR019734 Tetratricopeptide repeat
214 247 SMART SM00028 tpr_5
180 213 SMART SM00028 tpr_5
180 213 InterPro IPR019734 Tetratricopeptide repeat
107 140 SMART SM00028 tpr_5
107 140 InterPro IPR019734 Tetratricopeptide repeat
69 102 SMART SM00028 tpr_5
69 102 InterPro IPR019734 Tetratricopeptide repeat
1 16 Phobius SIGNAL_PEPTIDE Signal peptide region
4 11 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A085DE04
AlphaFold — — full sequence — Viewing
ColabFold VK055_1175
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.53 0.13
2 2.25 0.056
3 1.53 0.023
4 1.37 0.016