Metabolic network

VK055_1195

indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase

Back to protein
Network centrality 0.03542 top 94.4%
Chokepoint Yes

Attractive metabolic target: catalyzes a producing & consuming chokepoint reaction in Phenylalanine, tyrosine and tryptophan biosynthesis, no isoenzyme backup detected, more central than 94.4% of genes in this genome, no human homolog detected.

Pathways

KEGG pathways this gene's reaction(s) belong to.

Phenylalanine, tyrosine and tryptophan biosynthesis

Network

Two-hop reaction neighborhood around this protein; pathway boxes use one primary KEGG route per reaction when several mappings exist. Click a pathway box to open its full route map.

Reaction catalyzed by this protein Chokepoint reaction Neighbor reaction Pathway grouping (2+ reactions sharing a route) Connected reaction (arrow shows direction, when known) ⇌ Reversible reaction (double arrow) Cross-pathway connection

Selected reaction

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EC
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Pathway
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Isoenzymes
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Catalyzed reactions

Every reaction this gene catalyzes, with substrates/products and isoenzyme backup.

IGPSYN-RXN

EC 4.1.1.48 · IGPSYN-RXN · not reversible · no isoenzyme backup

H+ 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
→
(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate CO2 H2O

PRAISOM-RXN

EC 5.3.1.24 · PRAISOM-RXN · not reversible · no isoenzyme backup

Producing & consuming chokepoint
N-(5-phosphoribosyl)-anthranilate
→
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate

Imported from KpATCC43816.sbml · 2026-07-09