Protein profile

VK055_1254

putative oxidoreductase

Genome: KpATCC43816

Gene: AIK79877.1 Structure source: Experimental + ColabFold UniProt A0A0H3GLR2
Export view
Amino acids 183
Annotations 3
Features 11
PDB binders 0
Druggability 0.872

Overview

Basic information about this protein and its source genome.

Accession
VK055_1254
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK79877.1
Status
annotated
Amino acids
183
Structure source
Experimental + ColabFold
EC
1.-.-.-
GO
GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0000166 Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
78.689
DEG E-value
2.7e-107
Localization
Cytoplasmic
ColabFold pLDDT
97.83

Selected Druggability evidence

PDB experimental structure

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.872
Structure 7TMF
Pocket Pocket 1
P2Rank 0.244
Structure 7TMG
Pocket Pocket 1
ColabFold model
FPocket 0.225 · Pocket 1
P2Rank 0.305 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 122 / 4744 genomes with a hit
Normalized 0.026

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 2 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

2
  • GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
  • GO:0000166 Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
1 181 PIRSF PIRSF000232 YdjA
1 181 InterPro IPR026021 Putative NAD(P)H nitroreductase YdjA-like
4 162 CDD cd02135 YdjA-like
4 162 InterPro IPR026021 Putative NAD(P)H nitroreductase YdjA-like
1 175 Gene3D G3DSA:3.40.109.10 NADH Oxidase
1 175 InterPro IPR000415 Nitroreductase-like
2 181 PANTHER PTHR43821 NAD(P)H NITROREDUCTASE YDJA-RELATED
9 161 Pfam PF00881 Nitroreductase family
9 161 InterPro IPR029479 Nitroreductase
1 176 SUPERFAMILY SSF55469 FMN-dependent nitroreductase-like
1 176 InterPro IPR000415 Nitroreductase-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

2 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 7TMG
X-ray 1.90 Å A,B
100.0% 1-183
PDBe RCSB PDBj File
Viewing
PDB 7TMF
X-ray 1.97 Å A,B
100.0% 1-183
PDBe RCSB PDBj File
Loaded
ColabFold VK055_1254
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.967
2 0.933
6 0.289

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 5.61 0.27
2 5.31 0.25
3 2.78 0.085
4 2.54 0.071
5 1.36 0.016