Protein profile

VK055_1282

ybaK / prolyl-tRNA synthetases associated domainprotein

Genome: KpATCC43816

Gene: AIK79905.1 Structure source: AlphaFold + ColabFold UniProt A0A168WIJ5
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Amino acids 174
Annotations 2
Features 8
PDB binders 0
Druggability 0.78

Overview

Basic information about this protein and its source genome.

Accession
VK055_1282
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK79905.1
Status
annotated
Amino acids
174
Structure source
AlphaFold + ColabFold
GO
GO:0002161 The hydrolysis of an incorrectly aminoacylated tRNA. GO:0004812 Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
89.83

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.78
Structure A0A168WIJ5
Pocket Pocket 3
P2Rank 0.502
Structure A0A168WIJ5
Pocket Pocket 1
ColabFold model
FPocket 0.218 · Pocket 2
P2Rank 0.444 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 147 / 4744 genomes with a hit
Normalized 0.031

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0002161 The hydrolysis of an incorrectly aminoacylated tRNA.
  • GO:0004812 Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
29 160 Pfam PF04073 Aminoacyl-tRNA editing domain
29 160 InterPro IPR007214 YbaK/aminoacyl-tRNA synthetase-associated domain
3 172 Gene3D G3DSA:3.90.960.10 -
3 172 InterPro IPR036754 YbaK/aminoacyl-tRNA synthetase-associated domain superfamily
10 170 SUPERFAMILY SSF55826 YbaK/ProRS associated domain
10 170 InterPro IPR036754 YbaK/aminoacyl-tRNA synthetase-associated domain superfamily
10 171 CDD cd04336 YeaK
10 171 InterPro IPR044786 Multifunctional Ser/Thr-tRNA deacylase ProXp-y

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A168WIJ5
AlphaFold — — full sequence — Viewing
ColabFold VK055_1282
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.78
2 0.441

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 6.54 0.331