Protein profile

VK055_1317

bacterial regulatory, arsR family protein

Genome: KpATCC43816

Gene: AIK79940.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GLL1
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Amino acids 237
Annotations 7
Features 20
PDB binders 0
Druggability 0.989

Overview

Basic information about this protein and its source genome.

Accession
VK055_1317
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK79940.1
Status
annotated
Amino acids
237
Structure source
AlphaFold + ColabFold
GO
GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0097063 Binding to and responding, e.g. by conformational change, to changes in the cellular level of cadmium (Cd++). GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0032791 Binding to lead (Pb) ions. GO:0046686 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
88.81

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.989
Structure A0A0H3GLL1
Pocket Pocket 1
P2Rank 0.725
Structure A0A0H3GLL1
Pocket Pocket 1
ColabFold model
FPocket 0.54 · Pocket 9
P2Rank 0.724 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 68 / 4744 genomes with a hit
Normalized 0.014

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

7 GO

Gene Ontology (GO)

7
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0097063 Binding to and responding, e.g. by conformational change, to changes in the cellular level of cadmium (Cd++).
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0032791 Binding to lead (Pb) ions.
  • GO:0046686 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
  • GO:0010288 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lead ion stimulus.

Sequence Features

Domain/signature hits from InterPro and related databases.

20 records
Show feature table
Start End DB Term Name
57 72 PRINTS PR00778 Bacterial regulatory protein ArsR family signature
57 72 InterPro IPR001845 HTH ArsR-type DNA-binding domain
72 87 PRINTS PR00778 Bacterial regulatory protein ArsR family signature
72 87 InterPro IPR001845 HTH ArsR-type DNA-binding domain
24 39 PRINTS PR00778 Bacterial regulatory protein ArsR family signature
24 39 InterPro IPR001845 HTH ArsR-type DNA-binding domain
14 231 PANTHER PTHR39168 TRANSCRIPTIONAL REGULATOR-RELATED
22 95 NCBIfam NF033788 metalloregulator ArsR/SmtB family transcription factor
22 101 SMART SM00418 arsrmega2
22 101 InterPro IPR001845 HTH ArsR-type DNA-binding domain
5 110 Gene3D G3DSA:1.10.10.10 -
5 110 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
15 101 SUPERFAMILY SSF46785 Winged helix DNA-binding domain
15 101 InterPro IPR036390 Winged helix DNA-binding domain superfamily
29 74 Pfam PF01022 Bacterial regulatory protein, arsR family
29 74 InterPro IPR001845 HTH ArsR-type DNA-binding domain
12 107 ProSiteProfiles PS50987 ArsR-type HTH domain profile.
12 107 InterPro IPR001845 HTH ArsR-type DNA-binding domain
24 100 CDD cd00090 HTH_ARSR
24 100 InterPro IPR011991 ArsR-like helix-turn-helix domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GLL1
AlphaFold — — full sequence — Viewing
ColabFold VK055_1317
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.989

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 11.28 0.604
2 3.06 0.102
3 1.46 0.02