Protein profile

VK055_1404

periplasmic glucan biosynthesis, MdoG family protein

Genome: KpATCC43816

Gene: AIK80027.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GR37
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Amino acids 517
Annotations 7
Features 26
PDB binders 0
Druggability 0.43

Overview

Basic information about this protein and its source genome.

Accession
VK055_1404
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK80027.1
Status
annotated
Amino acids
517
Structure source
AlphaFold + ColabFold
GO
GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0030246 Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. GO:0005975 The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0016051 The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0030288 The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Periplasmic
ColabFold pLDDT
93.92

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.43
Structure A0A0H3GR37
Pocket Pocket 2
P2Rank 0.415
Structure A0A0H3GR37
Pocket Pocket 1
ColabFold model
FPocket 0.399 · Pocket 1
P2Rank 0.374 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 102 / 4744 genomes with a hit
Normalized 0.022

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

7 GO

Gene Ontology (GO)

7
  • GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
  • GO:0030246 Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.
  • GO:0005975 The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
  • GO:0016051 The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
  • GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
  • GO:0030288 The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
  • GO:0051274 The chemical reactions and pathways resulting in the formation of beta-glucans.

Sequence Features

Domain/signature hits from InterPro and related databases.

26 records
Show feature table
Start End DB Term Name
28 401 FunFam G3DSA:2.70.98.10:FF:000001 Glucans biosynthesis protein G
24 28 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
403 516 SUPERFAMILY SSF81296 E set domains
403 516 InterPro IPR014756 Immunoglobulin E-set
29 517 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 28 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
29 399 SUPERFAMILY SSF74650 Galactose mutarotase-like
29 399 InterPro IPR011013 Galactose mutarotase-like domain superfamily
12 31 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 28 SignalP_EUK SignalP-noTM SignalP-noTM
22 517 PANTHER PTHR30504 GLUCANS BIOSYNTHESIS PROTEIN
22 517 InterPro IPR014438 Glucan biosynthesis protein MdoG/MdoD
12 515 Hamap MF_01069 Glucans biosynthesis protein G [mdoG].
12 515 InterPro IPR023704 Glucan biosynthesis protein G
12 23 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
29 512 Pfam PF04349 Periplasmic glucan biosynthesis protein, MdoG
29 512 InterPro IPR007444 Glucan biosynthesis, periplasmic, MdoG C-terminal
404 517 Gene3D G3DSA:2.60.40.10 Immunoglobulins
404 517 InterPro IPR013783 Immunoglobulin-like fold
28 403 Gene3D G3DSA:2.70.98.10 -
28 403 InterPro IPR014718 Glycoside hydrolase-type carbohydrate-binding
1 11 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
404 517 FunFam G3DSA:2.60.40.10:FF:000294 Glucans biosynthesis protein G
1 28 Phobius SIGNAL_PEPTIDE Signal peptide region
2 517 PIRSF PIRSF006281 MdoG
2 517 InterPro IPR014438 Glucan biosynthesis protein MdoG/MdoD

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GR37
AlphaFold — — full sequence — Viewing
ColabFold VK055_1404
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.142
37 0.073
3 0.046
12 0.009

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 9.02 0.415
2 5.7 0.228
3 3.3 0.092
4 2.28 0.047
5 1.64 0.022