Protein profile

VK055_1478

binding-protein-dependent transport system innermembrane component family protein

Genome: KpATCC43816

Gene: AIK80099.1 Structure source: AlphaFold + ColabFold UniProt A0A658ZWR3

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Amino acids 500

Annotations 3

Features 61

PDB binders 0

Druggability 0.955

Overview

Basic information about this protein and its source genome.

Accession: VK055_1478
Assembly: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene: AIK80099.1
Status: annotated
Amino acids: 500
Structure source: AlphaFold + ColabFold

GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Human identity (%): 0.0
Gut microbiome off-target: hit
Essential (DEG): N
DEG identity (%): 37.281
Localization: CytoplasmicMembrane
ColabFold pLDDT: 91.25

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.955

Structure A0A658ZWR3

Pocket Pocket 18

P2Rank 0.974

Structure A0A658ZWR3

Pocket Pocket 1

ColabFold model

FPocket 0.809 · Pocket 17

P2Rank 0.972 · Pocket 1

Core conservation Accessory gene

Roary accessory

CoreCruncher accessory

Gut microbiome 36 / 4744 genomes with a hit

Normalized 0.008

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

61 records

Show feature table

Start	End	DB	Term	Name
24	46	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1	231	Gene3D	G3DSA:1.10.3720.10	-
1	231	InterPro	IPR035906	MetI-like superfamily
304	326	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
363	373	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1	21	SignalP_EUK	SignalP-TM	SignalP-TM
126	163	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
44	227	ProSiteProfiles	PS50928	ABC transporter integral membrane type-1 domain profile.
44	227	InterPro	IPR000515	ABC transporter type 1, transmembrane domain MetI-like
15	23	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.
3	14	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.
262	284	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
106	125	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
227	261	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
101	105	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
414	436	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
316	484	CDD	cd06261	TM_PBP2
316	484	InterPro	IPR000515	ABC transporter type 1, transmembrane domain MetI-like
304	326	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
110	132	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
469	492	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
414	438	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
47	68	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
188	206	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
439	468	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
78	100	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
394	413	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
80	100	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
44	215	CDD	cd06261	TM_PBP2
44	215	InterPro	IPR000515	ABC transporter type 1, transmembrane domain MetI-like
493	500	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
2	496	PANTHER	PTHR43357	INNER MEMBRANE ABC TRANSPORTER PERMEASE PROTEIN YDCV
1	23	Phobius	SIGNAL_PEPTIDE	Signal peptide region
300	490	ProSiteProfiles	PS50928	ABC transporter integral membrane type-1 domain profile.
300	490	InterPro	IPR000515	ABC transporter type 1, transmembrane domain MetI-like
162	184	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
2	24	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
338	362	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
69	79	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
469	491	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
47	69	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
207	226	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
260	492	SUPERFAMILY	SSF161098	MetI-like
260	492	InterPro	IPR035906	MetI-like superfamily
1	2	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.
371	393	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
204	226	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
285	303	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
374	393	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
339	361	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
323	497	Pfam	PF00528	Binding-protein-dependent transport system inner membrane component
323	497	InterPro	IPR000515	ABC transporter type 1, transmembrane domain MetI-like
77	224	Pfam	PF00528	Binding-protein-dependent transport system inner membrane component
77	224	InterPro	IPR000515	ABC transporter type 1, transmembrane domain MetI-like
6	226	SUPERFAMILY	SSF161098	MetI-like
6	226	InterPro	IPR035906	MetI-like superfamily
164	187	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
327	337	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
259	497	Gene3D	G3DSA:1.10.3720.10	-
259	497	InterPro	IPR035906	MetI-like superfamily
262	284	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold AF_A0A658ZWR3	AlphaFold	—	—	full sequence	—	Viewing
ColabFold VK055_1478	ColabFold	—	—	full sequence	—	Loaded

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
18				0.955
19				0.837
29				0.754

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK	Score	Probability
1	38.88	0.961
2	3.13	0.105
3	2.28	0.057
4	1.95	0.04
5	1.57	0.024

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
17				0.809
9				0.806
29				0.264
16				0.226

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK	Score	Probability
1	39.25	0.961
2	3.91	0.153
3	2.28	0.057
4	1.69	0.029
5	1.54	0.023