Protein profile

VK055_1482

anti-anti-sigma factor family protein

Genome: KpATCC43816

Gene: AIK80103.1 Structure source: AlphaFold + ColabFold UniProt A0A333D354
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Amino acids 112
Annotations 2
Features 12
PDB binders 0
Druggability 0.361

Overview

Basic information about this protein and its source genome.

Accession
VK055_1482
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK80103.1
Status
annotated
Amino acids
112
Structure source
AlphaFold + ColabFold
GO
GO:0043856 The function of binding to an anti-sigma factor and stopping, preventing or reducing the rate of its activity. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
31.25
Localization
Cytoplasmic
ColabFold pLDDT
93.46

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.361
Structure A0A333D354
Pocket Pocket 1
P2Rank
Structure A0A333D354
Pocket No pockets
ColabFold model
FPocket 0.263 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 23 / 4744 genomes with a hit
Normalized 0.005

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0043856 The function of binding to an anti-sigma factor and stopping, preventing or reducing the rate of its activity.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
13 110 ProSiteProfiles PS50801 STAS domain profile.
13 110 InterPro IPR002645 STAS domain
7 110 PANTHER PTHR33495 ANTI-SIGMA FACTOR ANTAGONIST TM_1081-RELATED-RELATED
1 111 Gene3D G3DSA:3.30.750.24 STAS domain
1 111 InterPro IPR036513 STAS domain superfamily
3 106 Pfam PF01740 STAS domain
3 106 InterPro IPR002645 STAS domain
2 103 NCBIfam TIGR00377 anti-sigma factor antagonist
2 103 InterPro IPR003658 Anti-sigma factor antagonist
3 99 CDD cd07043 STAS_anti-anti-sigma_factors
1 108 SUPERFAMILY SSF52091 SpoIIaa-like
1 108 InterPro IPR036513 STAS domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A333D354
AlphaFold — — full sequence — Viewing
ColabFold VK055_1482
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.361
2 0.007
3 0.001