Protein profile

VK055_1635

ATPase subunit of terminase family protein

Genome: KpATCC43816

Gene: AIK80255.1 Structure source: AlphaFold + ColabFold UniProt A0A483L9D3
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Amino acids 592
Annotations 2
Features 10
PDB binders 0
Druggability 0.392

Overview

Basic information about this protein and its source genome.

Accession
VK055_1635
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK80255.1
Status
annotated
Amino acids
592
Structure source
AlphaFold + ColabFold
GO
GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0019069 The assembly of a virus capsid from its protein subunits.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
84.68

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.392
Structure A0A483L9D3
Pocket Pocket 5
P2Rank 0.389
Structure A0A483L9D3
Pocket Pocket 1
ColabFold model
FPocket 0.538 · Pocket 39
P2Rank 0.604 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 20 / 4744 genomes with a hit
Normalized 0.004

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0019069 The assembly of a virus capsid from its protein subunits.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
377 573 Gene3D G3DSA:3.30.420.240 -
166 387 Pfam PF03237 Terminase large subunit, T4likevirus-type, N-terminal
87 309 Gene3D G3DSA:3.40.50.300 -
87 309 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
415 573 Pfam PF17289 Terminase RNaseH-like domain
415 573 InterPro IPR035421 Terminase, large subunit gp17-like, C-terminal
9 63 Pfam PF06056 Putative ATPase subunit of terminase (gpP-like)
9 63 InterPro IPR010332 ATPase terminase subunit, putative
100 126 MobiDBLite mobidb-lite consensus disorder prediction
112 126 MobiDBLite mobidb-lite consensus disorder prediction

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A483L9D3
AlphaFold — — full sequence — Viewing
ColabFold VK055_1635
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
36 0.045
13 0.011
38 0.005
1 0.001

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 8.56 0.389
2 7.78 0.347
3 6.77 0.291
4 4.21 0.142
5 3.73 0.115